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By Philippe Lévesque Emergency doctor in a cardio-pulmonary specialized hospital
Daniel Lindholm, Christoph Varenhorst, Christopher P Cannon, Robert A Harrington, Anders Himmelmann, Juan Maya, Steen Husted, Philippe Gabriel Steg, Jan H Cornel, Robert F Storey, Susanna R Stevens, Lars Wallentin, Stefan K James
AIMS: The optimal platelet inhibition strategy for ACS patients managed without revascularization is unknown. We aimed to evaluate efficacy and safety of ticagrelor vs. clopidogrel in the non-ST-elevation acute coronary syndrome (NSTE-ACS) subgroup of the PLATO trial, in the total cohort, and in the subgroups managed with and without revascularization within 10 days of randomization. METHODS AND RESULTS: We performed a retrospective analysis of the primary endpoint of cardiovascular death/myocardial infarction/stroke...
August 14, 2014: European Heart Journal
Spyros D Mentzelopoulos, Sotirios Malachias, Christos Chamos, Demetrios Konstantopoulos, Theodora Ntaidou, Androula Papastylianou, Iosifinia Kolliantzaki, Maria Theodoridi, Helen Ischaki, Dimosthemis Makris, Epaminondas Zakynthinos, Elias Zintzaras, Sotirios Sourlas, Stavros Aloizos, Spyros G Zakynthinos
IMPORTANCE: Among patients with cardiac arrest, preliminary data have shown improved return of spontaneous circulation and survival to hospital discharge with the vasopressin-steroids-epinephrine (VSE) combination. OBJECTIVE: To determine whether combined vasopressin-epinephrine during cardiopulmonary resuscitation (CPR) and corticosteroid supplementation during and after CPR improve survival to hospital discharge with a Cerebral Performance Category (CPC) score of 1 or 2 in vasopressor-requiring, in-hospital cardiac arrest...
July 17, 2013: JAMA: the Journal of the American Medical Association
Stephen J Traub, Alice M Mitchell, Alan E Jones, Aimee Tang, Jennifer O'Connor, Teresa Nelson, John Kellum, Nathan I Shapiro
STUDY OBJECTIVE: We test the hypothesis that N-acetylcysteine plus normal saline solution is more effective than normal saline solution alone in the prevention of contrast-induced nephropathy. METHODS: The design was a randomized, double blind, 2-center, placebo-controlled interventional trial. Inclusion criteria were patients undergoing chest, abdominal, or pelvic computed tomography (CT) scan with intravenous contrast, older than 18 years, and at least one contrast-induced nephropathy risk factor...
November 2013: Annals of Emergency Medicine
Theresia Klima, Andreas Christ, Ivana Marana, Stefan Kalbermatter, Heiko Uthoff, Emanuel Burri, Sabine Hartwiger, Christian Schindler, Tobias Breidthardt, Giancarlo Marenzi, Christian Mueller
AIMS: The most effective regimen for the prevention of contrast-induced nephropathy (CIN) remains uncertain. Our purpose was to compare two regimens of sodium bicarbonate with 24 h sodium chloride 0.9% infusion in the prevention of CIN. METHODS AND RESULTS: We performed a prospective, randomized trial between March 2005 and December 2009, including 258 consecutive patients with renal insufficiency undergoing intravascular contrast procedures. Patients were randomized to receive intravenous volume supplementation with either (A) sodium chloride 0...
August 2012: European Heart Journal
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