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REVIEW
Sameera Rashid, Maria A Arafah, Mohammed Akhtar
Ovarian serous tumors and related lesions are one of the most common conditions of the female genital tract. While ovarian high-grade serous carcinoma carries high mortality and adverse prognosis, most other serous lesions have better clinical behavior. In recent years, significant progress has been made in understanding the nature and histogenesis of these lesions that has contributed to better and more precise clinical management. Most of the high-grade serous carcinomas involve the ovaries and/or peritoneum, although in most cases, their origin seems to be in the fallopian tube...
May 1, 2022: Advances in Anatomic Pathology
#2
REVIEW
Steven G Silverberg, C Blake Gilks
The field of gynaecological pathology has grown from its infancy to a mature subspecialty over the last 50 years. What discoveries have led the way in this evolution? On the basis of personal experience and a survey of expert gynaecological pathologists, the following discoveries have been most impactful: (i) identification of the role of human papillomavirus in the aetiology of carcinoma of the lower genital tract; (ii) the emergence of international classification systems for gynaecological cancers (with cervical adenocarcinoma being the most recent example of this); (iii) the development of reliable immunohistochemistry as a diagnostic adjunct; (iv) discoveries around the aetiology and the relationship between serous carcinoma of the tube/ovary and the endometrium; and (v) identification of the role of oestrogen in the development of endometrial carcinoma and histological recognition of the precursor lesion atypical hyperplasia/endometrial intraepithelial neoplasia, and how recognition of the role of diethylstilboestrol in the aetiology of vaginal clear cell carcinoma led directly to this discovery...
January 2020: Histopathology
#3
REVIEW
Ian A Cree, Valerie A White, B Iciar Indave, Dilani Lokuhetty
The upcoming revision of the World Health Organisation (WHO) classification of tumours of the female genital tract is scheduled for release in the second quarter of 2020. It will feature significant changes compared to earlier editions. In this review, we outline the process of revising this important reference source for those diagnosing tumours or engaged in cancer research and describe the significant changes. The WHO classification of tumours is increasingly evidence-based, with a clear update cycle, improved quality of illustrations and content, led by an editorial board comprised mainly of pathologists, but increasingly incorporating input from other disciplines...
January 2020: Histopathology
#4
JOURNAL ARTICLE
Glorimar Rivera-Colon, Hao Chen, Shuang Niu, Elena Lucas, Steven Holloway, Kelley Carrick, Katja Gwin, Jayanthi Lea, Wenxin Zheng
The pattern-based classification system of endocervical adenocarcinoma correlates with nodal metastasis and clinical outcomes, but its application in biopsies is challenging. The aim of this study was the correlation of additional histologic features with patterns of invasion as well as prognosis. A total of 103 specimens from 71 cervical adenocarcinoma cases were studied. Among the 71 cases, all had resection specimens including hysterectomy, cold knife cone excision or loop electrosurgical excision procedure excision, and 32 of these had prior cervical biopsies...
February 2020: American Journal of Surgical Pathology
#5
JOURNAL ARTICLE
Pavla Sustova, Jerzy Klijanienko
The aim of this study was to determine the accuracy of fine-needle aspiration (FNA) and core needle biopsy (CNB) for palpable breast tumors (PBTs). FNA and CNB of 492 PBTs from 477 patients were analyzed. Tumors were malignant in 473 cases and benign in 19 cases. There was a strong correlation (P > .05) between FNA and CNB in terms of malignancy. Among 473 malignant tumors, FNA had better accuracy and less unsatisfactory results (95.6%; 2.7%) than CNB (94.9%; 4.9%). Among 19 benign tumors, CNB was accurate in 100% compared to 94...
January 2020: Diagnostic Cytopathology
#6
JOURNAL ARTICLE
Inmaculada Nicolás, Adela Saco, Esther Barnadas, Lorena Marimon, Natalia Rakislova, Pere Fusté, Angeles Rovirosa, Lydia Gaba, Laura Buñesch, Blanca Gil-Ibañez, Jaume Pahisa, Berta Díaz-Feijoo, Aureli Torne, Jaume Ordi, Marta Del Pino
Human papillomaviruses (HPVs) are the causative agents of carcinoma of the uterine cervix. A number of HPV genotypes have been associated with cervical cancer and almost all tumors associated with HPV show strong p16 expression. However, there is little information on the possible impact of the HPV genotype and p16 immunostaining on the clinicopathological features or their prognostic value in cervical carcinoma. We evaluated a series of 194 patients with HPV-positive cervical cancers treated at our institution, focusing on the clinicopathological features and the relationship of the HPV genotypes and p16 immunostaining with the prognosis...
January 2020: Modern Pathology
#7
REVIEW
Yeh Wang, Kristen Nicholes, Ie-Ming Shih
Recent molecular genetic findings on endometriosis and normal endometrium suggest a modified model in which circulating epithelial progenitor or stem cells intended to regenerate uterine endometrium after menstruation may become overreactive and trapped outside the uterus. These trapped epithelium-committed progenitor cells form nascent glands through clonal expansion and recruit polyclonal stromal cells, leading to the establishment of deep infiltrating endometriosis. Once formed, the ectopic tissue becomes subject to immune surveillance, resulting in chronic inflammation...
January 24, 2020: Annual Review of Pathology
#8
JOURNAL ARTICLE
Nicola S Meagher, Linyuan Wang, Peter F Rambau, Maria P Intermaggio, David G Huntsman, Lynne R Wilkens, Mona A El-Bahrawy, Roberta B Ness, Kunle Odunsi, Helen Steed, Esther Herpel, Michael S Anglesio, Bonnie Zhang, Neil Lambie, Anthony J Swerdlow, Jan Lubiński, Robert A Vierkant, Ellen L Goode, Usha Menon, Aleksandra Toloczko-Grabarek, Oleg Oszurek, Sanela Bilic, Aline Talhouk, Montserrat García-Closas, Qin Wang, Adeline Tan, Rhonda Farrell, Catherine J Kennedy, Mercedes Jimenez-Linan, Karin Sundfeldt, John L Etter, Janusz Menkiszak, Marc T Goodman, Paul Klonowski, Yee Leung, Stacey J Winham, Kirsten B Moysich, Sabine Behrens, Tomasz Kluz, Robert P Edwards, Jacek Gronwald, Francesmary Modugno, Brenda Y Hernandez, Christine Chow, Linda E Kelemen, Gary L Keeney, Michael E Carney, Yanina Natanzon, Gregory Robertson, Raghwa Sharma, Simon A Gayther, Jennifer Alsop, Hugh Luk, Chloe Karpinskyj, Ian Campbell, Peter Sinn, Aleksandra Gentry-Maharaj, Penny Coulson, Jenny Chang-Claude, Mitul Shah, Martin Widschwendter, Katrina Tang, Minouk J Schoemaker, Jennifer M Koziak, Linda S Cook, James D Brenton, Frances Daley, Björg Kristjansdottir, Constantina Mateoiu, Melissa C Larson, Paul R Harnett, Audrey Jung, Anna deFazio, Kylie L Gorringe, Paul D P Pharoah, Parham Minoo, Colin Stewart, Oliver F Bathe, Xianyong Gui, Paul Cohen, Susan J Ramus, Martin Köbel
Primary ovarian mucinous tumors can be difficult to distinguish from metastatic gastrointestinal neoplasms by histology alone. The expected immunoprofile of a suspected metastatic lower gastrointestinal tumor is CK7- /CK20+ /CDX2+ /PAX8- . This study assesses the addition of a novel marker SATB2, to improve the diagnostic algorithm. A test cohort included 155 ovarian mucinous tumors (105 carcinomas and 50 borderline tumors) and 230 primary lower gastrointestinal neoplasms (123 colorectal adenocarcinomas and 107 appendiceal neoplasms)...
December 2019: Modern Pathology
#9
JOURNAL ARTICLE
Gunsu Kimyon Comert, Nazmiye Dincer, Alp Usubutun
AIM: To identify the value of processing multiple sections to detect metastasis in lymph nodes (LNs) dissected during gynecologic cancer surgery, and to evaluate the sizes of metastatic LNs in each region to compare with the largest one. MATERIALS AND METHODS: This retrospective study included 362 patients who had gynecologic cancer with at least one metastatic LN. Slides of 627 metastatic LN specimens were categorized according to the processing technique into single and more than one section (MOS) groups...
May 2019: International Journal of Surgical Pathology
#10
REVIEW
W Glenn McCluggage
Accurate staging of cancers is an important determinant of prognosis and guides optimal patient treatment. Although the International Collaboration on Cancer Reporting recommends that endometrial cancers (including carcinosarcomas) are pathologically staged using the International Federation of Gynecology and Obstetrics (FIGO) 2009 system, in many areas TNM [American Joint Committee on Cancer (AJCC) or Union for International Cancer Control (UICC)] staging is used or even mandated; these latter systems are based on FIGO 2009...
March 2018: Advances in Anatomic Pathology
#11
JOURNAL ARTICLE
Simona Stolnicu, Lien Hoang, Orsolya Hanko-Bauer, Iulia Barsan, Cristina Terinte, Anna Pesci, Sarit Aviel-Ronen, Takako Kiyokawa, Isabel Alvarado-Cabrero, Esther Oliva, Kay J Park, Robert A Soslow
Although 2014 World Health Organization criteria require unequivocal glandular and squamous differentiation for a diagnosis of cervical adenosquamous carcinoma, in practice, adenosquamous carcinoma diagnoses are often made in tumors that lack unequivocal squamous and/or glandular differentiation. Considering the ambiguous etiologic, morphological, and clinical features and outcomes associated with adenosquamous carcinomas, we sought to redefine these tumors. We reviewed slides from 59 initially diagnosed adenosquamous carcinomas (including glassy cell carcinoma and related lesions) to confirm an adenosquamous carcinoma diagnosis only in the presence of unequivocal malignant glandular and squamous differentiation...
February 2019: Modern Pathology
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