collection
https://read.qxmd.com/read/30415629/vitamin-d-supplements-and-prevention-of-cancer-and-cardiovascular-disease
#1
RANDOMIZED CONTROLLED TRIAL
JoAnn E Manson, Nancy R Cook, I-Min Lee, William Christen, Shari S Bassuk, Samia Mora, Heike Gibson, David Gordon, Trisha Copeland, Denise D'Agostino, Georgina Friedenberg, Claire Ridge, Vadim Bubes, Edward L Giovannucci, Walter C Willett, Julie E Buring
BACKGROUND: It is unclear whether supplementation with vitamin D reduces the risk of cancer or cardiovascular disease, and data from randomized trials are limited. METHODS: We conducted a nationwide, randomized, placebo-controlled trial, with a two-by-two factorial design, of vitamin D3 (cholecalciferol) at a dose of 2000 IU per day and marine n-3 (also called omega-3) fatty acids at a dose of 1 g per day for the prevention of cancer and cardiovascular disease among men 50 years of age or older and women 55 years of age or older in the United States...
January 3, 2019: New England Journal of Medicine
https://read.qxmd.com/read/30638909/carbohydrate-quality-and-human-health-a-series-of-systematic-reviews-and-meta-analyses
#2
JOURNAL ARTICLE
Andrew Reynolds, Jim Mann, John Cummings, Nicola Winter, Evelyn Mete, Lisa Te Morenga
BACKGROUND: Previous systematic reviews and meta-analyses explaining the relationship between carbohydrate quality and health have usually examined a single marker and a limited number of clinical outcomes. We aimed to more precisely quantify the predictive potential of several markers, to determine which markers are most useful, and to establish an evidence base for quantitative recommendations for intakes of dietary fibre. METHODS: We did a series of systematic reviews and meta-analyses of prospective studies published from database inception to April 30, 2017, and randomised controlled trials published from database inception to Feb 28, 2018, which reported on indicators of carbohydrate quality and non-communicable disease incidence, mortality, and risk factors...
February 2, 2019: Lancet
https://read.qxmd.com/read/30699315/oral-versus-intravenous-antibiotics-for-bone-and-joint-infection
#3
RANDOMIZED CONTROLLED TRIAL
Ho-Kwong Li, Ines Rombach, Rhea Zambellas, A Sarah Walker, Martin A McNally, Bridget L Atkins, Benjamin A Lipsky, Harriet C Hughes, Deepa Bose, Michelle Kümin, Claire Scarborough, Philippa C Matthews, Andrew J Brent, Jose Lomas, Roger Gundle, Mark Rogers, Adrian Taylor, Brian Angus, Ivor Byren, Anthony R Berendt, Simon Warren, Fiona E Fitzgerald, Damien J F Mack, Susan Hopkins, Jonathan Folb, Helen E Reynolds, Elinor Moore, Jocelyn Marshall, Neil Jenkins, Christopher E Moran, Andrew F Woodhouse, Samantha Stafford, R Andrew Seaton, Claire Vallance, Carolyn J Hemsley, Karen Bisnauthsing, Jonathan A T Sandoe, Ila Aggarwal, Simon C Ellis, Deborah J Bunn, Rebecca K Sutherland, Gavin Barlow, Cushla Cooper, Claudia Geue, Nicola McMeekin, Andrew H Briggs, Parham Sendi, Elham Khatamzas, Tri Wangrangsimakul, T H Nicholas Wong, Lucinda K Barrett, Abtin Alvand, C Fraser Old, Jennifer Bostock, John Paul, Graham Cooke, Guy E Thwaites, Philip Bejon, Matthew Scarborough
BACKGROUND: The management of complex orthopedic infections usually includes a prolonged course of intravenous antibiotic agents. We investigated whether oral antibiotic therapy is noninferior to intravenous antibiotic therapy for this indication. METHODS: We enrolled adults who were being treated for bone or joint infection at 26 U.K. centers. Within 7 days after surgery (or, if the infection was being managed without surgery, within 7 days after the start of antibiotic treatment), participants were randomly assigned to receive either intravenous or oral antibiotics to complete the first 6 weeks of therapy...
January 31, 2019: New England Journal of Medicine
https://read.qxmd.com/read/30045724/medications-that-reduce-emergency-hospital-admissions-an-overview-of-systematic-reviews-and-prioritisation-of-treatments
#4
REVIEW
Niklas Bobrovitz, Carl Heneghan, Igho Onakpoya, Benjamin Fletcher, Dylan Collins, Alice Tompson, Joseph Lee, David Nunan, Rebecca Fisher, Brittney Scott, Jack O'Sullivan, Oliver Van Hecke, Brian D Nicholson, Sarah Stevens, Nia Roberts, Kamal R Mahtani
BACKGROUND: Rates of emergency hospitalisations are increasing in many countries, leading to disruption in the quality of care and increases in cost. Therefore, identifying strategies to reduce emergency admission rates is a key priority. There have been large-scale evidence reviews to address this issue; however, there have been no reviews of medication therapies, which have the potential to reduce the use of emergency health-care services. The objectives of this study were to review systematically the evidence to identify medications that affect emergency hospital admissions and prioritise therapies for quality measurement and improvement...
July 26, 2018: BMC Medicine
https://read.qxmd.com/read/29698499/less-screen-time-and-more-frequent-vigorous-physical-activity-is-associated-with-lower-risk-of-reporting-negative-mental-health-symptoms-among-icelandic-adolescents
#5
JOURNAL ARTICLE
Soffia M Hrafnkelsdottir, Robert J Brychta, Vaka Rognvaldsdottir, Sunna Gestsdottir, Kong Y Chen, Erlingur Johannsson, Sigridur L Guðmundsdottir, Sigurbjorn A Arngrimsson
OBJECTIVE: Few studies have explored the potential interrelated associations of screen time and physical activity with mental health in youth, particularly using objective methods. We examined cross-sectional associations of these variables among Icelandic adolescents, using objective and subjective measurements of physical activity. METHODS: Data were collected in the spring of 2015 from 315 tenth grade students (mean age 15.8 years) in six elementary schools in metropolitan Reykjavík, Iceland...
2018: PloS One
https://read.qxmd.com/read/30146330/alcohol-use-and-burden-for-195-countries-and-territories-1990-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#6
REVIEW
(no author information available yet)
BACKGROUND: Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to health accounting within the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we generated improved estimates of alcohol use and alcohol-attributable deaths and disability-adjusted life-years (DALYs) for 195 locations from 1990 to 2016, for both sexes and for 5-year age groups between the ages of 15 years and 95 years and older...
September 22, 2018: Lancet
https://read.qxmd.com/read/30213495/one-year-survival-after-in-hospital-cardiac-arrest-a-systematic-review-and-meta-analysis
#7
JOURNAL ARTICLE
Marc Schluep, Benjamin Yaël Gravesteijn, Robert Jan Stolker, Henrik Endeman, Sanne Elisabeth Hoeks
INTRODUCTION: In-hospital cardiac arrest is a major adverse event with an incidence of 1-6/1000 admissions. It has been poorly researched and data on survival is limited. The outcome of interest in IHCA research is predominantly survival to discharge, however recent guidelines warrant for more long-term outcomes. In this systematic review we sought to quantitatively summarize one-year survival after in-hospital cardiac arrest. METHODS: For this systematic review and meta-analysis we performed a systematic search of all published data on one-year survival after IHCA up to March 9th, 2018...
November 2018: Resuscitation
https://read.qxmd.com/read/29167102/coffee-consumption-and-health-umbrella-review-of-meta-analyses-of-multiple-health-outcomes
#8
REVIEW
Robin Poole, Oliver J Kennedy, Paul Roderick, Jonathan A Fallowfield, Peter C Hayes, Julie Parkes
Objectives  To evaluate the existing evidence for associations between coffee consumption and multiple health outcomes. Design  Umbrella review of the evidence across meta-analyses of observational and interventional studies of coffee consumption and any health outcome. Data sources  PubMed, Embase, CINAHL, Cochrane Database of Systematic Reviews, and screening of references. Eligibility criteria for selecting studies  Meta-analyses of both observational and interventional studies that examined the associations between coffee consumption and any health outcome in any adult population in all countries and all settings...
November 22, 2017: BMJ: British Medical Journal
https://read.qxmd.com/read/29494855/effect-of-fluoxetine-on-three-year-recurrence-in-acute-ischemic-stroke-a-randomized-controlled-clinical-study
#9
RANDOMIZED CONTROLLED TRIAL
Yitao He, Zhili Cai, Siling Zeng, Siyan Chen, Bingshan Tang, Yubing Liang, Xin Chang, Yi Guo
OBJECTIVE: To evaluate the effect of fluoxetine on three-year recurrence rate of acute ischemic stroke. PATIENTS AND METHODS: 404 enrolled patients with acute ischemic stroke were randomly divided into control and treatment groups, and underwent conventional secondary preventive therapy for ischemic stroke. In addition, the treatment group was administered fluoxetine (20 mg daily for 90 days). A three-year follow-up was performed, and indicators related to risk factors of stroke were assessed at day 90 of follow-up...
May 2018: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/29635493/avocado-consumption-and-risk-factors-for-heart-disease-a-systematic-review-and-meta-analysis
#10
JOURNAL ARTICLE
Hiya A Mahmassani, Esther E Avendano, Gowri Raman, Elizabeth J Johnson
BACKGROUND: Nutrients in avocados are associated with cardiovascular benefits. OBJECTIVE: The aim of this study was to determine the effect of avocado intake on cardiovascular disease (CVD) risk with the use of a systematic review and meta-analysis. DESIGN: MEDLINE, Cochrane Central, and Commonwealth Agricultural Bureau abstracts were searched from 1946 through September 2017 for publications on avocado intake and CVD risk. All designs except for cross-sectional studies that evaluated avocado intake were included...
April 1, 2018: American Journal of Clinical Nutrition
https://read.qxmd.com/read/29731173/child-mortality-in-england-compared-with-sweden-a-birth-cohort-study
#11
COMPARATIVE STUDY
Ania Zylbersztejn, Ruth Gilbert, Anders Hjern, Linda Wijlaars, Pia Hardelid
BACKGROUND: Child mortality is almost twice as high in England compared with Sweden. We aimed to establish the extent to which adverse birth characteristics and socioeconomic factors explain this difference. METHODS: We developed nationally representative cohorts of singleton livebirths between Jan 1, 2003, and Dec 31, 2012, using the Hospital Episode Statistics in England, and the Swedish Medical Birth Register in Sweden, with longitudinal follow-up from linked hospital admissions and mortality records...
May 19, 2018: Lancet
1
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.