collection
https://read.qxmd.com/read/25829343/phase-angle-as-a-prognostic-marker-in-patients-with-critical-illness
#21
JOURNAL ARTICLE
Taís Kereski da Silva, Marina Carvalho Berbigier, Bibiana de Almeida Rubin, Rafael Barberena Moraes, Gabriela Corrêa Souza, Ingrid Dalira Schweigert Perry
BACKGROUND: Phase angle (PA) is interpreted as an indicator of cell membrane integrity and a prognostic indicator in some clinical situations. This study aims to evaluate PA as a prognostic marker in critically ill patients admitted to the intensive care unit (ICU) and associate this marker with length of hospital stay, mortality, and clinical scores. METHODS: A cohort study was conducted with 95 patients aged ≥18 years admitted to the ICU, who were assessed in terms of prognostic indexes (Acute Physiology and Chronic Health Evaluation II [APACHE II] and Sequential Organ Failure Assessment [SOFA]), clinical evolution (ICU discharge, death, and length of ICU stay), and PA...
April 2015: Nutrition in Clinical Practice
https://read.qxmd.com/read/25829640/the-success-model-for-laboratory-performance-and-execution-of-rapid-molecular-diagnostics-in-patients-with-sepsis
#22
JOURNAL ARTICLE
Mhair Dekmezian, Stacy G Beal, Mary Jane Damashek, Raul Benavides, Neelam Dhiman
Successful performance and execution of rapid diagnostics in a clinical laboratory hinges heavily on careful validation, accurate and timely communication of results, and real-time quality monitoring. Laboratories must develop strategies to integrate diagnostics with stewardship and evidence-based clinical practice guidelines. We present a collaborative SUCCESS model for execution and monitoring of rapid sepsis diagnostics to facilitate timely treatment. Six months after execution of the Verigene Gram-Positive Blood Culture (BC-GP) and the AdvanDx PNA-FISH assays, data were collected on 579 and 28 episodes of bacteremia and fungemia, respectively...
April 2015: Proceedings of the Baylor University Medical Center
https://read.qxmd.com/read/25829965/determinants-of-functional-status-among-survivors-of-severe-sepsis-and-septic-shock-one-year-follow-up
#23
JOURNAL ARTICLE
Mustafa S Al Khalaf, Fatimah H Al Ehnidi, Hasan M Al-Dorzi, Hani M Tamim, Noorizan Abd-Aziz, Balamurugan Tangiisuran, Yahaya Hassan, Yaseen M Arabi
RATIONALE: Sepsis is a leading cause of intensive care unit (ICU) admissions worldwide and a major cause of morbidity and mortality. Limited data exist regarding the outcomes and functional status among survivors of severe sepsis and septic shock. OBJECTIVES: This study aimed to determine the functional status among survivors of severe sepsis and septic shock a year after hospital discharge. METHODS: Adult patients admitted between April 2007 and March 2010 to the medical-surgical ICU of a tertiary hospital in Saudi Arabia, were included in this study...
April 2015: Annals of Thoracic Medicine
https://read.qxmd.com/read/25831399/the-importance-of-the-v-factor-escherichia-coli-bacteremia-and-sepsis
#24
COMMENT
Stephen F Murphy, Praveen Thumbikat
No abstract text is available yet for this article.
2015: Virulence
https://read.qxmd.com/read/25831703/-efficiency-of-high-volume-hemofiltration-in-patients-with-severe-sepsis-and-intracranial-hypertension
#25
JOURNAL ARTICLE
T S Musaeva, A P Berdnikov, S I Goncharenko, E A Denisova
We performed a retrospective study in 68 patients (144 procedures) with severe sepsis and intracranial hypertension measured by the pressure in the central retinal vein. The patients underwent high-volume hemofiltration (HV-HF) for extrarenal indications. Increased pressure in the central retinal vein was accompanied by critical points of cerebral perfusion pressure and the growth of neurological deficit with inhibition level of consciousness to coma 1. In this case, IHV-HF may be associated with the formation of the critical points of cerebral perfihsion and severe disorders of microcirculation and the lack of resolution of tissue hypoperfusion...
November 2014: Anesteziologiia i Reanimatologiia
https://read.qxmd.com/read/25834828/sepsis-pathogenesis-biomarkers-and-treatment
#26
EDITORIAL
Baoli Cheng, Andreas H Hoeft, Malte Book, Qiang Shu, Stephen M Pastores
No abstract text is available yet for this article.
2015: BioMed Research International
https://read.qxmd.com/read/25833826/low-zinc-and-selenium-concentrations-in-sepsis-are-associated-with-oxidative-damage-and-inflammation
#27
JOURNAL ARTICLE
K Mertens, D A Lowes, N R Webster, J Talib, L Hall, M J Davies, J H Beattie, H F Galley
BACKGROUND: Oxidative stress with dysregulated inflammation are hallmarks of sepsis. Zinc and selenium have important antioxidant functions, such that they could be important in patients with sepsis. We used an in vitro approach to assess the effect of zinc and selenium on oxidative stress, mitochondrial function, and inflammatory responses in conditions mimicking sepsis and related the findings to plasma concentrations and biomarkers in patients with and without sepsis. METHODS: Human endothelial cells were exposed to a range of zinc and selenium concentrations in conditions mimicking sepsis...
June 2015: British Journal of Anaesthesia
https://read.qxmd.com/read/25695167/is-procalcitonin-guided-antimicrobial-use-cost-effective-in-adult-patients-with-suspected-bacterial-infection-and-sepsis
#28
JOURNAL ARTICLE
Michelle Harrison, Curtis D Collins
OBJECTIVE: Procalcitonin has emerged as a promising biomarker of bacterial infection. Published literature demonstrates that use of procalcitonin testing and an associated treatment pathway reduces duration of antibiotic therapy without impacting mortality. The objective of this study was to determine the financial impact of utilizing a procalcitonin-guided treatment algorithm in hospitalized patients with sepsis. DESIGN: Cost-minimization and cost-utility analysis...
March 2015: Infection Control and Hospital Epidemiology
https://read.qxmd.com/read/25700050/should-heparin-be-used-to-treat-patients-with-severe-sepsis
#29
EDITORIAL
Andre C Kalil
No abstract text is available yet for this article.
March 2015: Critical Care Medicine
https://read.qxmd.com/read/25700053/what-is-old-is-new-again-acetaminophen-as-a-novel-approach-to-treating-sepsis
#30
EDITORIAL
Abdurrahman A Husain, Greg S Martin
No abstract text is available yet for this article.
March 2015: Critical Care Medicine
https://read.qxmd.com/read/25700055/the-adrenal-gland-and-corticosteroid-therapy-in-sepsis-i-certainly-remain-uncertain
#31
EDITORIAL
Brian M Fuller
No abstract text is available yet for this article.
March 2015: Critical Care Medicine
https://read.qxmd.com/read/25700057/lost-in-translation-on-lactate-hypotension-sepsis-induced-tissue-hypoperfusion-quantitative-resuscitation-and-surviving-sepsis-campaign-bundles
#32
EDITORIAL
https://read.qxmd.com/read/25700063/predicting-adrenal-insufficiency-in-severe-sepsis-the-role-of-plasma-free-cortisol
#33
EDITORIAL
Miklos D Kertai, Manuel L Fontes
No abstract text is available yet for this article.
March 2015: Critical Care Medicine
https://read.qxmd.com/read/25700070/serum-markers-of-sepsis-in-burn-patients-it-takes-more-to-convince
#34
LETTER
Anne-Françoise Rousseau, Nathalie Layios
No abstract text is available yet for this article.
March 2015: Critical Care Medicine
https://read.qxmd.com/read/25700072/antibiotic-initiation-in-severe-sepsis-does-sequence-impact-outcome
#35
LETTER
Abdullah Alhammad, Russell J Roberts, Greg Schumaker, John W Devlin
No abstract text is available yet for this article.
March 2015: Critical Care Medicine
https://read.qxmd.com/read/25493485/-antioxidant-protection-of-statins-in-acute-kidney-injury-induced-by-sepsis
#36
JOURNAL ARTICLE
Franciele do Nascimento Santos, Mirian Watanabe, Carolina Ferreira Vasco, Cassiane Dezoti da Fonseca, Maria de Fatima Fernandes Vattimo
OBJECTIVE: Evaluating the effect of preconditioning with simvastatin in acute kidney injury induced by sepsis. METHOD: Male adult Wistar rats were divided into the following groups: SHAM (control); SHAM+Statin (0.5 mg/kg simvastatin, orally); Sepsis (cecal puncture ligation - CPL); Sepsis+Statin. Physiological parameters, peritoneal fluid culture, renal function, oxidative metabolites, severity of acute kidney injury and animal survival were evaluated. RESULTS: The treatment with simvastatin in induced sepsis showed elevation of creatinine clearance with attenuation of generation of oxidative metabolites, lower severity of acute kidney injury and reduced mortality...
October 2014: Revista da Escola de Enfermagem da U S P
https://read.qxmd.com/read/25493972/the-efficacy-and-safety-of-heparin-in-patients-with-sepsis-a-systematic-review-and-metaanalysis
#37
REVIEW
Ryan Zarychanski, Ahmed M Abou-Setta, Salmaan Kanji, Alexis F Turgeon, Anand Kumar, Donald S Houston, Emily Rimmer, Brett L Houston, Lauralyn McIntyre, Alison E Fox-Robichaud, Paul Hébert, Deborah J Cook, Dean A Fergusson
OBJECTIVE: To evaluate the efficacy and safety of heparin in patients with sepsis, septic shock, or disseminated intravascular coagulation associated with infection. DESIGN: Systematic review and metaanalysis. DATA SOURCES: Randomized controlled trials from MEDLINE, EMBASE, CENTRAL, Global Health, Scopus, Web of Science, the International Clinical Trials Registry Platform (inception to April 2014), conference proceedings, and reference lists of relevant articles...
March 2015: Critical Care Medicine
https://read.qxmd.com/read/25494270/lactic-acidosis
#38
REVIEW
Jeffrey A Kraut, Nicolaos E Madias
New England Journal of Medicine, Volume 371, Issue 24, Page 2309-2319, December 2014.
December 11, 2014: New England Journal of Medicine
https://read.qxmd.com/read/25480508/modulating-lps-signal-transduction-at-the-lps-receptor-complex-with-synthetic-lipid-a-analogues
#39
REVIEW
Aileen F B White, Alexei V Demchenko
Sepsis, defined as a clinical syndrome brought about by an amplified and dysregulated inflammatory response to infections, is one of the leading causes of death worldwide. Despite persistent attempts to develop treatment strategies to manage sepsis in the clinical setting, the basic elements of treatment have not changed since the 1960s. As such, the development of effective therapies for reducing inflammatory reactions and end-organ dysfunction in critically ill patients with sepsis remains a global priority...
2014: Advances in Carbohydrate Chemistry and Biochemistry
https://read.qxmd.com/read/25479113/lactate-measurements-in-sepsis-induced-tissue-hypoperfusion-results-from-the-surviving-sepsis-campaign-database
#40
MULTICENTER STUDY
Brian Casserly, Gary S Phillips, Christa Schorr, R Phillip Dellinger, Sean R Townsend, Tiffany M Osborn, Konrad Reinhart, Narendran Selvakumar, Mitchell M Levy
OBJECTIVE: The Surviving Sepsis Campaign guidelines recommend obtaining a serum lactate measurement within 6 hours of presentation for all patients with suspected severe sepsis or septic shock. A lactate greater than 4 mmol/L qualifies for administration of early quantitative resuscitation therapy. We evaluated lactate elevation (with special attention to values > 4 mmol/L) and presence or absence of hypotension as a marker of clinical outcome. DESIGN AND SETTING: The Surviving Sepsis Campaign developed a database to assess the overall effect of the sepsis bundles as a performance improvement tool for clinical practice and patient outcome...
March 2015: Critical Care Medicine
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