Meta analisis compara las distintas estatinas en cuanto a seguridad

BACKGROUND: Our objective was to estimate the comparative harms of individual statins using both placebo-controlled and active-comparator trials. METHODS AND RESULTS: We systematically reviewed randomized trials evaluating different statins in participants with and without cardiovascular disease. We performed random-effects pairwise and network meta-analyses to quantify the relative harms of individual statins. We included 55 two-armed placebo-controlled and 80 two- or multiarmed active-comparator trials including 246,955 individuals...