Luca Cantarini, Antonio Vitale, Orso Maria Lucherini, Caterina De Clemente, Francesco Caso, Luisa Costa, Giacomo Emmi, Elena Silvestri, Flora Magnotti, Maria Cristina Maggio, Eugenia Prinzi, Giuseppe Lopalco, Bruno Frediani, Rolando Cimaz, Mauro Galeazzi, Donato Rigante
Autoinflammatory disorders (AIDs) are a novel class of diseases elicited by mutations in genes regulating the homeostasis of innate immune complexes, named inflammasomes, which lead to uncontrolled oversecretion of the proinflammatory cytokine interleukin-1β. Protean inflammatory symptoms are variably associated with periodic fever, depicting multiple specific conditions. Childhood is usually the lifetime in which most hereditary AIDs start, though still a relevant number of patients may experience a delayed disease onset and receive a definite diagnosis during adulthood...
January 2015: Clinical Rheumatology