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Ralph Gruber, Richard Panayiotou, Emma Nye, Bradley Spencer-Dene, Gordon Stamp, Axel Behrens
BACKGROUND & AIMS: Pancreatitis is the most important risk factor for pancreatic ductal adenocarcinoma (PDAC). Pancreatitis predisposes to PDAC because it induces a process of acinar cell reprogramming known as acinar-to-ductal metaplasia (ADM)-a precursor of pancreatic intraepithelial neoplasia lesions that can progress to PDAC. Mutations in KRAS are found at the earliest stages of pancreatic tumorigenesis, and it appears to be a gatekeeper to cancer progression. We investigated how mutations in KRAS cooperate with pancreatitis to promote pancreatic cancer progression in mice...
September 2016: Gastroenterology
Michael Basson
No abstract text is available yet for this article.
March 4, 2014: Nature Medicine
Amin Ardestani, Federico Paroni, Zahra Azizi, Supreet Kaur, Vrushali Khobragade, Ting Yuan, Thomas Frogne, Wufan Tao, Jose Oberholzer, Francois Pattou, Julie Kerr Conte, Kathrin Maedler
Apoptotic cell death is a hallmark of the loss of insulin-producing beta cells in all forms of diabetes mellitus. Current treatments fail to halt the decline in functional beta cell mass, and strategies to prevent beta cell apoptosis and dysfunction are urgently needed. Here, we identified mammalian sterile 20-like kinase-1 (MST1) as a critical regulator of apoptotic beta cell death and function. Under diabetogenic conditions, MST1 was strongly activated in beta cells in human and mouse islets and specifically induced the mitochondrial-dependent pathway of apoptosis through upregulation of the BCL-2 homology-3 (BH3)-only protein BIM...
April 2014: Nature Medicine
Lilian Anekwe
No abstract text is available yet for this article.
February 22, 2014: Lancet
Victor Molina, Laura Visa, Carles Conill, Salvador Navarro, Jose M Escudero, Jose M Auge, Xavier Filella, Miguel A Lopez-Boado, Joana Ferrer, Laureano Fernandez-Cruz, Rafael Molina
CA 19.9 serum levels were prospectively determined in 573 patients admitted to hospital for suspicion of pancreatic cancer. The final diagnosis was 77 patients with no malignancy, 389 patients with pancreatic cancer, 37 neuroendocrine pancreatic cancer, 28 cholangiocarcinomas, 4 gallbladder cancer, 27 ampullary carcinomas, and 11 periampullary carcinomas. CA 19.9 was determined using a commercial assay from Roche Diagnostics, and 37 U/ml was considered as the upper limit of normality. Abnormal CA 19.9 serum levels were found in 27%, 81...
June 2012: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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