Advances in antimicrobials.

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By Mohamed Elmustafa Elsayed Infectious diseases and medical microbiology trainee, severn infection sciences. Member of the royal college of physicians, London. Member of the british infection association, member of the healthcare infection society, member of the european society of clinical microbiology and infectious diseases.
Sima L Sharara, Joe Amoah, Zoi D Pana, Patricia J Simner, Sara E Cosgrove, Pranita D Tamma
BACKGROUND: Limited data exist regarding the efficacy of piperacillin-tazobactam (TZP) for the management of non-bacteremic pyelonephritis caused by ESBL-producing organisms. METHODS: We conducted a multicenter observational study comparing clinical outcomes in adults hospitalized with ESBL-producing pyelonephritis receiving TZP versus carbapenems using an inverse probability of treatment weighted propensity score analysis. Patients were eligible for inclusion if all of the following criteria were met: (1) urine cultures growing Escherichia coli, Klebsiella pneumoniae, K...
December 20, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Louis D Saravolatz, Gary E Stein
Delafloxacin (ABT 492) is a new fluoroquinolone available in both oral and parenteral formulations. It has recently been approved by the Food and Drug Administration for the management of acute bacterial skin and skin structure infections. When compared to combination therapy of vancomycin and aztreonam, delafloxacin was not inferior and had a favorable adverse event profile. Furthermore, its anti-methicillin-resistant Staphylococcus aureus (MRSA) activity and favorable clinical response in MRSA infections distinguishes it from other fluoroquinolones...
March 5, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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