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https://read.qxmd.com/read/31307948/efficacy-and-safety-of-dolutegravir-rilpivirine-for-maintenance-of-virological-suppression-in-adults-with-hiv-1-100-week-data-from-the-randomised-open-label-phase-3-sword-1-and-sword-2-studies
#1
RANDOMIZED CONTROLLED TRIAL
Michael Aboud, Chloe Orkin, Daniel Podzamczer, Johannes R Bogner, David Baker, Marie-Aude Khuong-Josses, David Parks, Konstantinos Angelis, Lesley P Kahl, Elizabeth A Blair, Kimberly Adkison, Mark Underwood, Jessica E Matthews, Brian Wynne, Kati Vandermeulen, Martin Gartland, Kimberly Smith
BACKGROUND: Primary analyses of the SWORD-1 and SWORD-2 trials at 48 weeks showed that switching to a two-drug regimen of dolutegravir plus rilpivirine was non-inferior to continuing a standard three-drug or four-drug antiretroviral regimen for maintenance of virological suppression in people with HIV-1. Here, we present efficacy and safety data from the 100-week analysis of the trials. METHODS: SWORD-1 and SWORD-2 are identically designed, randomised, open-label phase 3 studies at 65 centres in 13 countries and 60 centres in 11 countries, respectively...
September 2019: Lancet HIV
https://read.qxmd.com/read/29507971/direct-acting-antiviral-prophylaxis-in-kidney-transplantation-from-hepatitis-c-virus-infected-donors-to-noninfected-recipients-an-open-label-nonrandomized-trial
#2
Christine M Durand, Mary G Bowring, Diane M Brown, Michael A Chattergoon, Guido Massaccesi, Nichole Bair, Russell Wesson, Ashraf Reyad, Fizza F Naqvi, Darin Ostrander, Jeremy Sugarman, Dorry L Segev, Mark Sulkowski, Niraj M Desai
Background: Given the high mortality rate for patients with end-stage kidney disease receiving dialysis and the efficacy and safety of hepatitis C virus (HCV) treatments, discarded kidneys from HCV-infected donors may be a neglected public health resource. Objective: To determine the tolerability and feasibility of using direct-acting antivirals (DAAs) as prophylaxis before and after kidney transplantation from HCV-infected donors to non-HCV-infected recipients (that is, HCV D+/R- transplantation)...
April 17, 2018: Annals of Internal Medicine
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