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EDITORIAL
Maha Reda Farhat, Karen Rita Jacobson
Active case finding leveraging new molecular diagnostics and chest X-rays with automated interpretation algorithms is increasingly being developed for high-risk populations to drive down tuberculosis incidence. We consider why such an approach did not deliver a decline in tuberculosis prevalence in Brazilian prison populations and what to consider next.
April 18, 2024: Clinical Infectious Diseases
#2
JOURNAL ARTICLE
Sho Fukui, Masato Okada, Tomohiro Shinozaki, Takahiro Asano, Takehiro Nakai, Hiromichi Tamaki, Mitsumasa Kishimoto, Hiroshi Hasegawa, Takeaki Matsuda, Javier Marrugo, Sara K Tedeschi, Hyon Choi, Daniel H Solomon
INTRODUCTION: Despite the established cross-sectional association between alcohol intake and serum urate (SU), its longitudinal association remains unknown. This study aimed to determine whether changes in alcohol intake have a clinically relevant association with SU change. METHOD: We conducted retrospective analyses using systematically collected annual medical examination data from October 2012 to October 2022 in a Japanese preventive medicine centre. The exposure was changes in alcohol intake between two consecutive visits...
February 28, 2024: Annals of the Rheumatic Diseases
#3
JOURNAL ARTICLE
Li Fan, Yan Li, Wenting Lyu, Qingqing Xu, Yujuan Gao, Xiaohua Qiu, Hourong Cai, Jinghong Dai
OBJECTIVES: To assess the impacts of high-dose intravenous methylprednisolone pulse (IVMP) therapy in survival and the occurrences of treatment-related infection of patients with anti-melanoma differentiation-associated gene 5 antibody-related rapidly progressive interstitial lung disease (MDA5-RPILD). METHODS: Patients with MDA5-RPILD from June 2017 to August 2022 in our hospital were retrospectively reviewed. IVMP therapy was defined as intravenous methylprednisolone (mPSL) 0...
January 30, 2024: Clinical Rheumatology
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RANDOMIZED CONTROLLED TRIAL
Reza Zonozi, Frank B Cortazar, Anushya Jeyabalan, Gabriel Sauvage, Pravarut Nithagon, Noah R Huizenga, Jillian M Rosenthal, Alexander Sipilief, Katherine Cosgrove, Karen A Laliberte, Eugene P Rhee, William F Pendergraft, John L Niles
OBJECTIVE: To compare two long-term remission maintenance strategies for antineutrophil cytoplasmic antibody (ANCA) vasculitis. METHODS: We conducted a prospective, single-centre, open-label, randomised controlled trial of patients with ANCA vasculitis in remission after completing at least 2 years of fixed-schedule rituximab. In the B cell arm, rituximab was reinfused upon B cell repopulation; in the ANCA arm, rituximab was reinfused upon significant rise in ANCA level...
February 15, 2024: Annals of the Rheumatic Diseases
#5
JOURNAL ARTICLE
Fabian Proft, Murat Torgutalp, Burkhard Muche, Valeria Rios Rodriguez, Joachim Listing, Mikhail Protopopov, Judith Rademacher, Hildrun Haibel, Laura Spiller, Anne-Katrin Weber, Maryna Verba, Jan Brandt-Juergens, Uta Kiltz, Maren Sieburg, Swen Jacki, Joachim Sieper, Denis Poddubnyy
OBJECTIVES: The study aimed to evaluate the effect of adding a non-steroidal anti-inflammatory drug (NSAID), celecoxib (CEL), to a tumour necrosis factor inhibitor (TNFi), golimumab (GOL), compared with TNFi monotherapy on radiographic spinal progression in patients with radiographic axial spondyloarthritis (r-axSpA) over 2 years. METHODS: R-axSpA patients, having risk factors for radiographic progression (high disease activity plus C reactive protein >5 mg/L and/or ≥1 syndesmophyte(s)), underwent a 12-week run-in phase with GOL 50 mg every 4 weeks...
January 16, 2024: Annals of the Rheumatic Diseases
#6
JOURNAL ARTICLE
Stefano Rodolfi, Emanuel Della-Torre, Lucia Bongiovanni, Puja Mehta, David C Fajgenbaum, Carlo Selmi
Lymphadenopathy is a common clinical finding and diagnostic challenge within general medicine and rheumatology practice. It may represent a primary manifestation of an underlying immune-mediated disease or indicate an infectious or neoplastic complication requiring differing management. Evaluating lymphadenopathy is of particular relevance in rheumatology, given that lymph node enlargement is a common finding within the clinical spectrum of several well-known rheumatologic disorders including rheumatoid arthritis, systemic lupus erythematosus, and Sjögren syndrome...
December 18, 2023: Rheumatology
#7
JOURNAL ARTICLE
Jose Manuel Mascaro, Ignasi Rodriguez-Pinto, Gabriela Poza, Anna Mensa-Vilaro, Julian Fernandez-Martin, Luis Caminal-Montero, Gerard Espinosa, Jose Hernández-Rodríguez, Marina Diaz, Joana Rita-Marques, Raimon Sanmarti, Santos Castañeda, Dolores Colunga, Rubén Coto-Hernández, Patricia Fanlo, Jose Ignacio Elejalde, Segundo Bujan, Ignasi Figueras, Francisco Manuel Marco, Mariano Andrés, Silvia Suárez, Andres Gonzalez-Garcia, Xavier Fustà-Novell, Clara Garcia-Belando, Ana Granados, Maria Teresa Fernandez-Figueras, Neus Quilis, Maria Orriols-Caba, Ricardo Gómez de la Torre, Maria Cinta Cid, Georgina Espígol-Frigolé, Alba Alvarez-Abella, Eztizen Labrador, Maria Rozman, Monica Lopez-Guerra, Paola Castillo, Jose R Alamo-Moreno, Eva Gonzalez-Roca, Susana Plaza, Virginia Fabregat, Rocio Lara, Esther F Vicente-Rabaneda, Sonia Tejedor-Vaquero, Giuliana Magri, Nuria Bonet, Manuel Solis-Moruno, Andrea Cerutti, Oscar Fornas, Ferran Casals, Jordi Yagüe, Juan I Aróstegui
BACKGROUND: The vacuoles, E1-enzyme, X linked, autoinflammatory and somatic (VEXAS) syndrome is an adult-onset autoinflammatory disease (AID) due to postzygotic UBA1 variants. OBJECTIVES: To investigate the presence of VEXAS syndrome among patients with adult-onset undiagnosed AID. Additional studies evaluated the mosaicism distribution and the circulating cytokines. METHODS: Gene analyses were performed by both Sanger and amplicon-based deep sequencing...
December 2023: Annals of the Rheumatic Diseases
#8
JOURNAL ARTICLE
Arielle Mendel, Hassan Behlouli, Cristiano Soares de Moura, Évelyne Vinet, Jeffrey R Curtis, Sasha Bernatsky
BACKGROUND: Antibiotic prophylaxis is recommended during ANCA-associated vasculitis (AAV) induction. We aimed to describe the frequency, persistence, and factors associated with trimethoprim-sulfamethoxazole (TMP-SMX) use in an adult population sample with granulomatosis with polyangiitis (GPA) treated with rituximab (RTX). METHODS: We identified adults with GPA treated with RTX within the Merative™ Marketscan® Research Databases (2011-2020). TMP-SMX prophylaxis was defined as a [Formula: see text] 28-day prescription dispensed within a month of starting RTX...
July 29, 2023: Arthritis Research & Therapy
#9
REVIEW
Nikita Ashcherkin, Archna A Patel, Alicia Algeciras-Schimnich, Krupa B Doshi
Bisphosphonates are widely used as first-line therapy to slow bone loss and decrease fracture risk in postmenopausal women with osteoporosis. Nonadherence to oral bisphosphonates diminishes the benefit of reduced bone loss and fracture risk of these medications. Strategies to enhance osteoporosis monitoring and adherence to therapy are crucial to improve outcomes. Dual-energy x-ray absorptiometry (DXA) is the gold standard for monitoring bone mineral density but is slow to detect change after initiation of oral bisphosphonate therapy...
January 3, 2023: Cleveland Clinic Journal of Medicine
#10
JOURNAL ARTICLE
Steven Ronsmans, Paul D Blanc
The first modern description linking rheumatoid arthritis to occupational dust exposure is generally attributed to the British physician Anthony Caplan. In 1953, Caplan reported on a "peculiar" nodular pattern on chest radiographs of Welsh coal miners with rheumatoid arthritis that differed from the typical coal workers' pneumoconiosis. However, as early as 1950, the Belgian rheumatologist Émile Colinet described a similar case of rheumatoid arthritis and concomitant pulmonary opacities in a 30-year-old woman with silica exposure...
January 10, 2023: Annals of Internal Medicine
#11
JOURNAL ARTICLE
Suchitra Chandrasekaran, Martina L Badell, Denise J Jamieson
No abstract text is available yet for this article.
May 3, 2022: JAMA
#12
JOURNAL ARTICLE
Upendra Rathore, Saloni Haldule, Latika Gupta
No abstract text is available yet for this article.
July 1, 2021: Rheumatology
#13
REVIEW
Puja Mehta, Randy Q Cron, James Hartwell, Jessica J Manson, Rachel S Tattersall
The term cytokine storm syndromes describes conditions characterised by a life-threatening, fulminant hypercytokinaemia with high mortality. Cytokine storm syndromes can be genetic or a secondary complication of autoimmune or autoinflammatory disorders, infections, and haematological malignancies. These syndromes represent a key area of interface between rheumatology and general medicine. Rheumatologists often lead in management, in view of their experience using intensive immunosuppressive regimens and managing cytokine storm syndromes in the context of rheumatic disorders or infection (known as secondary haemophagocytic lymphohistiocytosis or macrophage activation syndrome [sHLH/MAS])...
June 2020: Lancet Rheumatology
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JOURNAL ARTICLE
Hawre Jalal, Jeanine M Buchanich, David R Sinclair, Mark S Roberts, Donald S Burke
The ongoing substance misuse epidemic in the United States is complex and dynamic and should be approached as such in the development and evaluation of policy1 . Drug overdose deaths (largely attributable to opioid misuse) in the United States have grown exponentially for almost four decades, but the mechanisms of this growth are poorly understood2 . From analysis of 661,565 overdose deaths from 1999 to 2017, we show that the age-specific drug overdose mortality curve for each birth-year cohort rises and falls according to a Gaussian-shaped curve...
May 2020: Nature Medicine
#15
JOURNAL ARTICLE
Verónica Chacón-Dulcey, Jeaneth López-Labady, Mariana Villarroel-Dorrego, Jennifer Frías, Wirman Tirado, Nieves González, Ricardo Pérez Alfonzo
INTRODUCTION: Lupus erythematosus (LE) is an autoimmune disease often treated with antimalarial drugs. The prolonged use of chloroquine and hydroxychloroquine can cause hyperpigmentation in the skin, oral mucosa and retinal pigment epithelium, which in turn can trigger toxicity in this epithelium, which in some cases causes vision loss. The objective of the present work was to establish the association between the presence of oral pigmented macules by antimalarial and secondary retinal toxicity...
June 2020: Lupus
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JOURNAL ARTICLE
Edoardo Cipolletta, Andrea Di Matteo, Anna Scanu, Martina Isidori, Jacopo Di Battista, Leonardo Punzi, Walter Grassi, Emilio Filippucci
The main aim of this systematic literature review (SLR) was to summarise the evidence in the use of biological therapies in calcium pyrophosphate deposition disease (CPPD). We performed a SLR using PubMed, Embase and Cochrane databases. Only studies reporting the efficacy of biologics in CPPD were selected. The search resulted in 83 articles; 11 were further evaluated in the SLR. Seventy-six patients were included: 2 received infliximab, whereas 74 anakinra. Anakinra was used in refractory disease (85.1%) or in patients with contraindications to standard treatments (23...
September 2020: Clinical and Experimental Rheumatology
#17
REVIEW
Mara Felicetti, Elena Treppo, Chiara Posarelli, Francesco Ferro, Milena Bond, Sara Monti, Elena Elefante, Francesca Trentin, Paolo Delvino, Rosaria Talarico, Chiara Baldini, Luca Quartuccio
Systemic vasculitides are a group of diseases that could potentially affect any organ with heterogeneous clinical manifestations that usually depend on the size of the most involved vessels. These diseases could be associated with a relevant burden of mortality and morbidity if not early recognised and treated. Moreover, even if they are usually rare diseases, their incidence and prevalence seem to be increasing in the last decade, partially because of improved awareness and management of vasculitis from physicians...
2020: Clinical and Experimental Rheumatology
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JOURNAL ARTICLE
Shanshan Li, Liufu Cui, Jin Cheng, Rong Shu, Shuohua Chen, Uyen-Sa Nguyen, Devyani Misra, Shouling Wu, Xiang Gao
BACKGROUND: Longitudinal evidence on change of serum urate level with mortality risk is limited as prior studies have a measurement of serum urate at a single time point. Further, the combined effect of serum urate and systemic inflammation on mortality is unknown. METHODS: We conducted a prospective cohort study of 152,358 participants (122,045 men and 30,313 women) with repeated measurements of serum urate in 2006, 2008, 2010, and 2012 (107,751 participants had all four measurements of serum urate)...
April 15, 2020: Arthritis Research & Therapy
#19
JOURNAL ARTICLE
Hironari Hanaoka, Tetsuya Nishimoto, Yuka Okazaki, Tsutomu Takeuchi, Masataka Kuwana
BACKGROUND: Foxp3 is a marker for regulatory T cells (Treg cells), but recent studies have shown the plasticity and heterogeneity of CD4+ Foxp3+ T cells. This study aimed to examine the phenotype and function of circulating CD4+ Foxp3+ T cells in patients with systemic lupus erythematosus (SLE). METHODS: We enrolled 47 patients with SLE, 31 with organ-specific autoimmune diseases (15 with multiple sclerosis and 16 with primary immune thrombocytopenia), and 19 healthy subjects...
April 21, 2020: Arthritis Research & Therapy
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JOURNAL ARTICLE
Gisèle Khoury, Jacques Morel, Bernard Combe, Cédric Lukas
BACKGROUND: The objective of this study was to compare in real life the occurrence of anterior uveitis in patients with spondyloarthritis (SpA), including psoriatic arthritis (PsA), treated with the soluble-receptor etanercept (ETA) or monoclonal antibodies (mAbs). METHODS: This was an observational, retrolective study. Patients with SpA who were prescribed anti-TNF agents between 2000 and 2014 were included. The risk of uveitis was interpreted qualitatively (number of subjects with at least one uveitis) and quantitatively (number of uveitis flares for each individual)...
April 26, 2020: Arthritis Research & Therapy
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