collection
https://read.qxmd.com/read/23989094/daily-sedation-interruption-versus-targeted-light-sedation-strategies-in-icu-patients
#1
REVIEW
Christopher G Hughes, Timothy D Girard, Pratik P Pandharipande
OBJECTIVE: The updated clinical practice guidelines for the management of pain, agitation, and delirium recommend either daily sedation interruption or maintaining light levels of sedation as methods to improve outcomes for patients who are sedated in the ICU. We review the evidence supporting both methods and discuss whether one method is preferable or if they should be used concurrently. DATA SOURCE: Original research articles identified using the electronic PubMed database...
September 2013: Critical Care Medicine
https://read.qxmd.com/read/18191684/efficacy-and-safety-of-a-paired-sedation-and-ventilator-weaning-protocol-for-mechanically-ventilated-patients-in-intensive-care-awakening-and-breathing-controlled-trial-a-randomised-controlled-trial
#2
RANDOMIZED CONTROLLED TRIAL
Timothy D Girard, John P Kress, Barry D Fuchs, Jason W W Thomason, William D Schweickert, Brenda T Pun, Darren B Taichman, Jan G Dunn, Anne S Pohlman, Paul A Kinniry, James C Jackson, Angelo E Canonico, Richard W Light, Ayumi K Shintani, Jennifer L Thompson, Sharon M Gordon, Jesse B Hall, Robert S Dittus, Gordon R Bernard, E Wesley Ely
BACKGROUND: Approaches to removal of sedation and mechanical ventilation for critically ill patients vary widely. Our aim was to assess a protocol that paired spontaneous awakening trials (SATs)-ie, daily interruption of sedatives-with spontaneous breathing trials (SBTs). METHODS: In four tertiary-care hospitals, we randomly assigned 336 mechanically ventilated patients in intensive care to management with a daily SAT followed by an SBT (intervention group; n=168) or with sedation per usual care plus a daily SBT (control group; n=168)...
January 12, 2008: Lancet
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