collection
https://read.qxmd.com/read/37768189/initial-management-and-potential-opportunities-to-deprescribe-dialysis-among-patients-with-aki-d-patients-after-hospital-discharge
#21
JOURNAL ARTICLE
Ian E McCoy, Eric Weinhandl, Wael Hussein, Chi-Yuan Hsu
Dialysis-requiring AKI (AKI-D) now accounts for more than 15% of outpatient hemodialysis initiations; over 30% of these patients with AKI-D may have potential to recover. However, little is known about strategies currently used to treat outpatient AKI-D and screen for recovery. In this study of 1754 patients with AKI-D, we found that ( 1 ) the initial dialysis orders were similar to those of patients with contemporary incident ESKD, despite different treatment goals; ( 2 ) timed urine collections were completed in only a minority of patients; and ( 3 ) most patients with AKI-D who recovered discontinued dialysis without ever having been weaned from their initial dialysis prescription, suggesting there may be substantial opportunity to wean dialysis sooner...
December 1, 2023: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/37734691/outcomes-of-patients-with-left-ventricular-assist-devices-requiring-intermittent-hemodialysis-single-center-cohort-systematic-review-and-individual-participant-data-meta-analysis
#22
REVIEW
Adrian daSilva-deAbreu, Christian Faaborg-Andersen, Abdulaziz Joury, Austin Tutor, Sapna Desai, Clement Eiswirth, Selim R Krim, James Wever-Pinzon, Carl J Lavie, Hector O Ventura
INTRODUCTION: Patients with left ventricular assist devices (LVADs) who require intermittent hemodialysis (iHD) are considered to have a poor prognosis despite a paucity of supportive evidence, mostly from small single-center cohorts and extrapolations from studies of patients who received continuous renal replacement therapy but no iHD. METHODS/RESULTS: We conducted a systematic review and individual-participant-data meta-analysis of the literature including our single-center cohort to examine the outcomes of patients initiated on iHD following LVAD implantation...
September 19, 2023: Current Problems in Cardiology
https://read.qxmd.com/read/37690142/a-clinical-model-to-predict-successful-renal-replacement-therapy-rrt-discontinuation-in-patients-with-acute-kidney-injury-aki
#23
JOURNAL ARTICLE
Eduardo de Oliveira Valle, Igor Smolentzov, João Lucas Martins Gorzoni, Isabela Cavalcante Salgado, Lorena Catelan Mainardes, Vanessa Oliveira Gomes, Charles Hamilton Mélo Júnior, Camila Eleuterio Rodrigues, José Mauro Vieira Júnior
INTRODUCTION: Ideal timing of Renal Replacement Therapy (RRT) discontinuation in Acute Kidney Injury (AKI) is still unknown. We aimed to study the role of creatinine-related variables in predicting RRT successful discontinuation and to propose a clinical predictive score. METHODS: In this single-centre retrospective study, we evaluated all AKI patients in whom RRT was interrupted for at least 48 hours. Patients who were still RRT-independent 7 days after initial RRT cessation were included in the "Success" group and opposed to the "Failure" group...
2023: Clinics
https://read.qxmd.com/read/37611867/a-comprehensive-description-of-kidney-disease-progression-after-acute-kidney-injury-from-a-prospective-parallel-group-cohort-study
#24
JOURNAL ARTICLE
Kerry L Horne, Daniela Viramontes-Hörner, Rebecca Packington, John Monaghan, Susan Shaw, Aleli Akani, Timothy Reilly, Thomas Trimble, Grazziela Figueredo, Nicholas M Selby
Acute kidney injury (AKI) is associated with adverse long-term outcomes, but many studies are retrospective, focused on specific patient groups or lack adequate comparators. The ARID (AKI Risk in Derby) Study was a five-year prospective parallel-group cohort study to examine this. Hospitalized cohorts with and without exposure to AKI were matched 1:1 for age, baseline kidney function, and diabetes. Estimated glomerular filtration rate (eGFR) and the urinary albumin:creatinine ratio (uACR) were measured at three-months, one-, three- and five-years...
August 21, 2023: Kidney International
https://read.qxmd.com/read/37573145/recovery-of-kidney-function-after-acute-kidney-disease-a-multi-cohort-analysis
#25
JOURNAL ARTICLE
Simon Sawhney, William Ball, Samira Bell, Corri Black, Christian Fynbo Christiansen, Uffe Heide-Jørgensen, Simon Kok Jensen, Emilie Lambourg, Paul E Ronksley, Zhi Tan, Marcello Tonelli, Matthew T James
BACKGROUND: There are no consensus definitions for evaluating kidney function recovery after acute kidney injury (AKI) and acute kidney disease (AKD), nor is it clear how recovery varies across populations and clinical subsets. We present a federated analysis of four population-based cohorts from Canada, Denmark, and Scotland, 2011-2018. METHODS: We identified incident AKD defined by serum creatinine changes within 48 hours, 7 days, and 90 days based on KDIGO AKI and AKD criteria...
August 12, 2023: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/37545022/renin-angiotensin-aldosterone-system-blockade-after-aki-with-or-without-recovery-among-us-veterans-with-diabetic-kidney-disease
#26
JOURNAL ARTICLE
Daniel P Murphy, Julian Wolfson, Scott Reule, Kirsten L Johansen, Areef Ishani, Paul E Drawz
SIGNIFICANCE STATEMENT: Among patients with CKD, optimal use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers after AKI is uncertain. Despite these medications' ability to reduce risk of mortality and other adverse outcomes, there is concern that ACEi/ARB use may delay recovery of kidney function or precipitate recurrent AKI. Prior studies have provided conflicting data regarding the optimal timing of these medications after AKI and have not addressed the role of kidney recovery in determining appropriate timing...
October 1, 2023: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/37540960/early-renal-recovery-after-acute-kidney-injury-in-patients-on-venoarterial-extracorporeal-membrane-oxygenation-a-retrospective-study
#27
JOURNAL ARTICLE
Alexandre Sitbon, Maxime Coutrot, Santiago Montero, Juliette Chommeloux, Guillaume Lebreton, Florent Huang, Thomas Frapard, Benjamin Assouline, Marc Pineton De Chambrun, Guillaume Hekimian, Charles Edouard Luyt, Alain Combes, Matthieu Schmidt
PURPOSE: The impact of VA-ECMO on early renal recovery (within 7 days after ECMO onset) in patients with pre-ECMO acute kidney injury and cardiogenic shock is unknown. MATERIAL AND METHODS: This retrospective single-center study included adult patients with cardiogenic shock rescued by VA-ECMO and severe AKI occurring before ECMO implantation (pre-ECMO AKI). Patients with early renal recovery (defined as at least a 50% decrease in peak serum creatinine or weaning from renal replacement therapy) were compared to patients without early renal recovery...
August 2, 2023: Journal of Critical Care
https://read.qxmd.com/read/37507979/impaired-nrf2-inhibits-recovery-from-ischemic-reperfusion-injury-in-the-aging-kidney
#28
JOURNAL ARTICLE
Min Jee Jo, Ji Eun Kim, So Yon Bae, Eunjung Cho, Shin Young Ahn, Young Joo Kwon, Gang-Jee Ko
Deteriorating kidney function is frequently observed in the elderly population, as well as vulnerability to acute kidney failure, such as ischemic/reperfusion injury (IRI), and inadequate recovery from IRI is one of the mechanisms of kidney dysfunction in the elderly. The potential mediators in the progression of kidney dysfunction in the aging kidney have not yet been clearly revealed. In this study, we investigated the role of nuclear factor erythroid 2-related factor 2 (NRF2), which is an essential regulator of cellular redox homeostasis, in restoring kidney function after IRI in the aging kidney...
July 18, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/37427615/evaluation-of-predictive-factors-of-renal-function-recovery-in-renal-failure-secondary-to-urinary-tract-obstruction
#29
JOURNAL ARTICLE
Sara Rasheed Kalwar, Naveed Mahar, Murli Lal, Mohsin Mustafa Memon, Harris Hassan Qureshi, Manzoor Hussain
OBJECTIVE: To determine the factors associated with renal function recovery in individuals with kidney failure due to obstruction in the urinary tract. METHODS: The prospective, descriptive study was conducted July 2020 to August 2021 at the Department of Urology, Sindh Institute of Urology and Transplantation, Karachi, and comprised adult patients of either gender who had renal failure secondary to obstructive urinary tract. Baseline data regarding patients' variables, including age, gender, duration of symptoms (<25 days or >25 days), haemoglobin (<9...
June 2023: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/37241121/clinical-and-biochemical-profile-associated-with-renal-recovery-after-acute-kidney-injury-in-a-mexican-population-retrospective-cohort-study
#30
JOURNAL ARTICLE
Josué I Ruiz-Gallardo, Enrique Cervantes-Pérez, Andrea Pérez de Acha-Chávez, Guillermo A Cervantes-Cardona, Sol Ramírez-Ochoa, Adriana Nápoles-Echauri, Alejandro González-Ojeda, Clotilde Fuentes-Orozco, Francisco Javier Hernández-Mora, Eduardo Gómez-Sánchez, Jorge I Michel-González, Carlos Miguel González-Valencia, Gabino Cervantes-Guevara
Background and Objectives : Our primary objective was to study the clinical and biochemical characteristics associated with acute kidney injury (AKI) remission in a group of Mexican patients. Materials and methods : We retrospectively enrolled 75 patients who were diagnosed with AKI and separated the sample into two groups: nonremitting patients ( n = 27, 36%) vs. remitting patients ( n = 48, 64%). Results : We found significant relationships between nonremitting AKI and previous diagnosis of chronic kidney disease ( p = 0...
May 6, 2023: Medicina
https://read.qxmd.com/read/37102520/pathological-features-of-recovery-or-progression-in-acute-tubular-necrosis-single-centre-study
#31
JOURNAL ARTICLE
Amin R Soliman, Fadia M Boles, Khaled M Sadek
Acute tubular necrosis (ATN) is the most important and frequent cause of acute kidney injury (AKI). Controversy exists concerning the role of renal biopsy in the evaluation of ATN prognosis. We aim in our study to evaluate the role of renal biopsy for the detection of recovery and progression and rate of recovery of ATN. The study was designed to include all biopsies with the diagnosis in ATN in adults >21-year-old, from January 2016 to December 2018. Biopsies were recruited retrospectively and were reviewed by three pathologists and quantitated...
February 2022: Saudi Journal of Kidney Diseases and Transplantation
https://read.qxmd.com/read/37071648/predictive-models-for-kidney-recovery-and-death-in-patients-continuing-dialysis-as-outpatients-after-starting-in-hospital
#32
JOURNAL ARTICLE
Edward G Clark, Matthew T James, Swapnil Hiremath, Manish M Sood, Ron Wald, Amit X Garg, Samuel A Silver, Zhi Tan, Carl van Walraven
BACKGROUND: For patients who initiate dialysis during a hospital admission and continue to require dialysis after discharge, outpatient dialysis management could be improved by better understanding the future likelihood of recovery to dialysis-independence and the competing risk of death. METHODS: We derived and validated linked models to predict the subsequent recovery to dialysis-independence and death within one year of hospital discharge using a population-based cohort of 7,657 patients in Ontario, Canada...
April 18, 2023: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/37049436/sustained-recovery-of-kidney-function-in-patients-with-eskd-under-chronic-dialysis-treatment-systematic-review-and-meta-analysis
#33
REVIEW
Carlo Garofalo, Chiara Ruotolo, Claudia Annoiato, Maria Elena Liberti, Roberto Minutolo, Luca De Nicola, Giuseppe Conte, Silvio Borrelli
The prevalence of recovery of kidney function (RKF) in patients under maintenance dialysis is poorly defined mainly because of different definitions of RKF. Therefore, to gain more insights into the epidemiology of RKF, we performed a systematic review and meta-analysis of studies addressing the prevalence of sustained (at least for 30 days) RKF in patients under maintenance dialysis. Acute kidney injury (AKI) and RKF in the first 90 days of dialysis were the main exclusion criteria. Overall, 7 studies (10 cohorts) including 2,444,943 chronic dialysis patients (range: 430-1,900,595 patients) were meta-analyzed...
March 25, 2023: Nutrients
https://read.qxmd.com/read/37017637/functional-recovery-after-partial-nephrectomy-next-generation-analysis
#34
JOURNAL ARTICLE
Carlos Munoz-Lopez, Kieran Lewis, Worapat Attawettayanon, Yosuke Yasuda, João Pedro Emrich Accioly, Nityam Rathi, Zaeem Lone, Melissa Boumitri, Rebecca A Campbell, Andrew Wood, Jihad H Kaouk, Georges-Pascal Haber, Mohamad Eltemamy, Venkatesh Krishnamurthi, Robert Abouassaly, Samuel C Haywood, Christopher J Weight, Steven C Campbell
OBJECTIVES: To provide a more rigorous assessment of factors affecting functional recovery after partial nephrectomy (PN) using novel tools that allow for analysis of more patients and improved accuracy for assessment of parenchymal volume loss, thereby revealing the potential impact of secondary factors such as ischaemia. PATIENTS AND METHODS: Of 1140 patients managed with PN (2012-2014), 670 (59%) had imaging and serum creatinine levels measured before and after PN necessary for inclusion...
August 2023: BJU International
https://read.qxmd.com/read/36848723/recovery-after-aki-effects-on-outcomes-over-15%C3%A2-years
#35
JOURNAL ARTICLE
Sadudee Peerapornratana, Marco Fiorentino, Priyanka Priyanka, Raghavan Murugan, John A Kellum
PURPOSE: To examine the effect of kidney recovery on mortality, dialysis and kidney transplantation up to 15 years after AKI. MATERIALS AND METHODS: We studied 29,726 survivors of critical illness and compared these outcomes stratified by AKI and recovery status at hospital discharge. Kidney recovery was defined as a return of serum creatinine to ≤150% of baseline without dialysis prior to hospital discharge. RESULTS: Overall AKI occurred in 59...
February 26, 2023: Journal of Critical Care
https://read.qxmd.com/read/36825344/identification-of-biomarkers-for-the-diagnosis-of-sepsis-associated-acute-kidney-injury-and-prediction-of-renal-recovery-in-the-intensive-care-unit
#36
JOURNAL ARTICLE
Se Hyun Kwak, Sunyoung Ahn, Mi Hwa Shin, Ah Young Leem, Su Hwan Lee, Kyungsoo Chung, Young Sam Kim, Sang-Guk Lee, Moo Suk Park
PURPOSE: Acute kidney injury (AKI) following sepsis is associated with higher mortality; however, reliable biomarkers for AKI development and recovery remain to be elucidated. MATERIALS AND METHODS: Patients with sepsis admitted to the medical intensive care unit (ICU) of Severance Hospital between June 2018 and May 2019 were prospectively analyzed. Patients were divided into those with and without AKI within 48 hours. Patients with septic AKI were subdivided into AKI-recovery and non-recovery groups based on whether their kidney injury recovered within 7 days...
March 2023: Yonsei Medical Journal
https://read.qxmd.com/read/36812025/the-prognostic-impact-of-acute-kidney-injury-recovery-patterns-in-critically-ill-patients-with-cirrhosis
#37
JOURNAL ARTICLE
Astin Worden, Francis Pike, Andrew S Allegretti, Harleen Kaur, Jennifer L Peng, Carla D Kettler, Eric S Orman, Archita P Desai, Lauren D Nephew, Marwan S Ghabril, Kavish R Patidar
BACKGROUND: The prognostic impact of acute kidney injury (AKI) recovery patterns in critically ill patients with cirrhosis is unknown. We aimed to compare mortality stratified by AKI-recovery patterns and identify predictors of mortality in patients with cirrhosis and AKI admitted to the intensive care unit (ICU). METHODS: Patients with cirrhosis and AKI from 2016-2018 at two tertiary-care ICUs were analyzed (N=322). AKI-recovery was defined by Acute Disease Quality Initiative (ADQI) consensus: return of serum creatinine <0...
January 3, 2023: Liver Transplantation
https://read.qxmd.com/read/36758525/biomarker-based-prediction-of-survival-and-recovery-of-kidney-function-in-acute-kidney-injury
#38
REVIEW
Daniel Patschan, Stefan Erfurt, Stefanie Oess, Martin Alexander Lauxmann, Susann Patschan, Oliver Ritter, Meike Hoffmeister
Background Acute kidney injury (AKI) affects increasing numbers of hospitalized patients, the prog-nosis remains poor. The diagnosis is still based on the 2012 published KDIGO criteria. Numerous new AKI biomarkers have been identified in recent years, they either reflect impaired excretory function or structural damage. The majority of markers are useful for AKI recognition under certain circumstances. Fewer data are available on the role of biomarkers in the prediction of in-hospital survival and renal recovery post-AKI...
February 9, 2023: Kidney & Blood Pressure Research
https://read.qxmd.com/read/36585609/reserve-and-resilience-in-ckd-concept-introduction-and-baseline-results-from-the-physical-resilience-prediction-in-advanced-renal-disease-prepared-study
#39
JOURNAL ARTICLE
C Barrett Bowling, Maren K Olsen, Theodore S Z Berkowitz, Battista Smith, Breana Floyd, Nadya Majette, Amy L Miles, Steven D Crowley, Virginia Wang, Matthew L Maciejewski, Heather E Whitson
BACKGROUND: The purpose of this manuscript is to introduce reserve and resilience as novel concepts in chronic kidney disease (CKD) research and present baseline data from a unique prospective cohort study designed to characterize recovery from functional decline after a health event. METHODS: The Physical REsilience Prediction in Advanced REnal Disease (PREPARED) study recruited a national, prospective cohort of Veterans ≥70 years old with an estimated glomerular filtration rate (eGFR) < 30 ml/min/1...
December 31, 2022: BMC Nephrology
https://read.qxmd.com/read/36159072/acute-kidney-injury-and-the-compensation-of-kidney-function-after-nephrectomy-in-living-donation
#40
REVIEW
Kenji Okumura, Holly Grace, Hiroshi Sogawa, Shigeyoshi Yamanaga
Acute kidney injury (AKI) incidence is growing rapidly, and AKI is one of the predictors of inpatient mortality. After nephrectomy, all the patients have decreased kidney function with AKI and recover from AKI. However, the characteristic and behavior of AKI is different from usual AKI and compensatory kidney function has been well known in the postoperative setting, especially in living donors. In this review, we have focused on the compensation of kidney function after nephrectomy in living donors. We discuss factors that have been identified as being associated with kidney recovery in donors including age, sex, body mass index, remnant kidney volume, estimated glomerular filtration rate, and various comorbidities...
August 18, 2022: World Journal of Transplantation
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