Jun Yu, Xiaojin Luan, Yidan Yan, Chen Qiao, Yuanyuan Liu, Dan Zhao, Bing Xie, Qianwen Zheng, Min Wang, Wanyin Chen, Cong Shen, Zeyu He, Xing Hu, Xiaoyan Huang, Hong Li, Binghai Chen, Bo Zheng, Xia Chen, Jie Fang
The ribonucleoprotein (RNP) spliceosome machinery triggers the precursor RNA splicing process in eukaryotes. Major spliceosome defects are implicated in male infertility; however, the underlying mechanistic links between the spliceosome and the ribosome in Drosophila testes remains largely unresolved. Small ribonucleoprotein particle protein SmD3 (SmD3) is a novel germline stem cell (GSC) regulatory gene identified in our previous screen of Drosophila testes. In the present study, using genetic manipulation in a Drosophila model, we demonstrated that SmD3 is required for the GSC niche and controls the self-renewal and differentiation of GSCs in the testis...
March 28, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology