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19 papers 0 to 25 followers Articulos de interes Neumología
James R Klinger, Gregory Elliott, Deborah J Levine, Eduardo Bossone, Laura Duvall, Karen Fagan, Julie Frantsve-Hawley, Steven M Kawut, John J Ryan, Erika B Rosenzweig, Nneka Sederstrom, Virginia D Steen, David B Badesch
BACKGROUND: Pulmonary arterial hypertension (PAH) carries a poor prognosis if not promptly diagnosed and appropriately treated. The development and approval of 14 medications over the last several decades has led to a rapidly evolving approach to therapy, and has necessitated periodic updating of evidence-based treatment guidelines. This guideline statement, which now includes a visual algorithm to enhance its clinical utility, represents the 4th iteration of the American College of Chest Physicians Guideline and Expert Panel Report on Pharmacotherapy for PAH...
January 14, 2019: Chest
Luca Richeldi, Francesco Varone, Miguel Bergna, Joao de Andrade, Jeremy Falk, Robert Hallowell, Stéphane Jouneau, Yasuhiro Kondoh, Lee Morrow, Winfried Randerath, Mary Strek, Gabriela Tabaj
A proportion of patients with interstitial lung diseases (ILDs) are at risk of developing a progressive-fibrosing phenotype, which is associated with a deterioration in lung function and early mortality. In addition to idiopathic pulmonary fibrosis (IPF), fibrosing ILDs that may present a progressive phenotype include idiopathic nonspecific interstitial pneumonia, connective tissue disease-associated ILDs, hypersensitivity pneumonitis, unclassifiable idiopathic interstitial pneumonia, ILDs related to other occupational exposures and sarcoidosis...
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
Suzanne C Lareau, Bonnie Fahy, Paula Meek, Angela Wang
No abstract text is available yet for this article.
January 1, 2019: American Journal of Respiratory and Critical Care Medicine
J Michael Ramsahai, Philip M Hansbro, Peter A B Wark
Acute asthma remains an important medical emergency, the most frequent cause of acute admissions in children and a major source of morbidity for adults with asthma. In all ages with asthma the presence of exacerbations is an important defining characteristic of asthma severity. In this review we will assess the epidemiology of acute asthma, the triggers of acute exacerbations and the mechanisms that underlie these exacerbations. We will also assess current treatments that prevent exacerbations, with an emphasis on the role of type 2 airway inflammation in the context of acute exacerbations and the novel treatments that effectively target this...
December 18, 2018: American Journal of Respiratory and Critical Care Medicine
Yuben Moodley
No abstract text is available yet for this article.
December 19, 2018: American Journal of Respiratory and Critical Care Medicine
Nazzareno Galiè, Vallerie V McLaughlin, Lewis J Rubin, Gerald Simonneau
No abstract text is available yet for this article.
December 14, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Steven D Nathan, Joan A Barbera, Sean P Gaine, Sergio Harari, Fernando J Martinez, Horst Olschewski, Karen M Olsson, Andrew J Peacock, Joanna Pepke-Zaba, Steeve Provencher, Norbert Weissmann, Werner Seeger
Pulmonary hypertension (PH) frequently complicates the course of patients with various forms of chronic lung disease (CLD). CLD-associated PH (CLD-PH) is invariably associated with reduced functional ability, impaired quality of life, greater oxygen requirements and an increased risk of mortality. The aetiology of CLD-PH is complex and multifactorial, with differences in the pathogenic sequelae between the diverse forms of CLD. Haemodynamic evaluation of PH severity should be contextualised within the extent of the underlying lung disease, which is best gauged through a combination of physiological and imaging assessment...
December 13, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Adam T Hill, Anita L Sullivan, James D Chalmers, Anthony De Soyza, Stuart J Elborn, Andres R Floto, Lizzie Grillo, Kevin Gruffydd-Jones, Alex Harvey, Charles S Haworth, Edwin Hiscocks, John R Hurst, Christopher Johnson, Peter W Kelleher, Pallavi Bedi, Karen Payne, Hashem Saleh, Nicholas J Screaton, Maeve Smith, Michael Tunney, Deborah Whitters, Robert Wilson, Michael R Loebinger
No abstract text is available yet for this article.
January 2019: Thorax
Or Kalchiem-Dekel, Jeffrey R Galvin, Allen P Burke, Sergei P Atamas, Nevins W Todd
Interstitial lung disease (ILD) and pulmonary fibrosis comprise a wide array of inflammatory and fibrotic lung diseases which are often confusing to general medicine and pulmonary physicians alike. In addition to the myriad of clinical and radiologic nomenclature used in ILD, histopathologic descriptors may be particularly confusing, and are often extrapolated to radiologic imaging patterns which may further add to the confusion. We propose that rather than focusing on precise histologic findings, focus should be on identifying an accurate etiology of ILD through a comprehensive and detailed medical history...
November 24, 2018: Journal of Clinical Medicine
Suzanne Lareau, Erika Moseson, Christopher G Slatore
No abstract text is available yet for this article.
December 1, 2018: American Journal of Respiratory and Critical Care Medicine
Paul A Bergl
No abstract text is available yet for this article.
October 30, 2018: American Journal of Respiratory and Critical Care Medicine
Pamela J McShane, Gregory Tino
Bronchiectasis is an important clinical syndrome because of its increasing prevalence, substantial economic burden on health care, and associated morbidity. Until recently, the disease was considered an orphan and essentially neglected from a therapeutic standpoint, but many recent advances have been made in the field. Several national registries have formed to provide databases from which to study patients with bronchiectasis. Experts published a consensus definition of a bronchiectasis-specific exacerbation that will serve as a unified definition for future clinical trials...
November 4, 2018: Chest
Jason D Chodakowski, D Mark Courtney
PURPOSE OF REVIEW: We provide a timely update on treatment care issues facing clinicians and patients with acute pulmonary embolism accompanied by either right ventricular strain (sub-massive pulmonary embolism) or shock (massive pulmonary embolism). RECENT FINDINGS: Care and research changes over the last several years have resulted in four important trends: more consensus and accuracy in the way acute pulmonary embolism severity is described and communicated among acute care clinicians and researchers, increased availability and use of risk prediction scoring systems, increased use of advanced invasive therapy in the setting of severe right ventricular dysfunction, and emergence of multidisciplinary pulmonary embolism response teams to guide standard care decision-making...
December 2018: Current Opinion in Critical Care
Fernando J Martinez, David J Lederer
As seen in this CME online activity (available at, idiopathic pulmonary fibrosis (IPF) is a specific form of chronic, progressive, fibrotic lung disease of unknown cause that is associated with substantial health-care utilization and high rates of mortality. The clinical symptoms of IPF are nonspecific and overlap with many pulmonary and cardiac diseases making differential diagnosis challenging. The American Thoracic Society/European Respiratory Society/Japanese Respiratory Society/Latin American Thoracic Association (ATS/ERS/JRS/ALAT) guidelines strongly recommend a multidisciplinary approach to the diagnosis of interstitial lung diseases; however, there are several limitations to the feasibility of this approach in clinical practice...
October 2018: Chest
Victor Kim, Shawn D Aaron
Chronic obstructive pulmonary disease (COPD) is a chronic illness that can be periodically punctuated by exacerbations, characterised by acute worsening of symptoms, including increased dyspnoea, cough, sputum production and sputum purulence. COPD exacerbations are common and have important clinical and economic consequences, including lost work productivity, increased utilisation of healthcare resources, temporary or permanent reductions in lung function and exercise capacity, hospitalisation, and sometimes death...
November 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Scott C Bell, Joseph S Elborn, Catherine A Byrnes
Interest in bronchiectasis has increased over the past two decades, as shown by the establishment of disease-specific registries in several countries, the publication of management guidelines and a growing number of clinical trials to address evidence gaps for treatment decisions. This review considers the evidence for defining and treating pulmonary exacerbations, the approaches for eradication of newly identified airway pathogens and the methods to prevent exacerbations through long-term treatments from a pragmatic practice-based perspective...
November 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
Diego J Maselli, Megan Hardin, Stephanie A Christenson, Nicola A Hanania, Craig P Hersh, Sandra G Adams, Antonio Anzueto, Jay I Peters, MeiLan K Han, Fernando J Martinez
Over the last few years, there has been a renewed interest in patients with characteristics of both asthma and COPD. Although the precise definition of asthma-COPD overlap (ACO) is still controversial, patients with overlapping features are frequently encountered in clinical practice, and may indeed have worse clinical outcomes and increased health-care utilization than those with asthma or COPD. Therefore, there is a critical need to set a framework for the therapeutic approach of such patients. There are key distinctions in the therapy between asthma and COPD, particularly regarding the initial choice of therapy...
August 2, 2018: Chest
Zofia Zwolska, Ewa Augustynowicz-Kopeć
Drug-resistant tuberculosis, and particularly multidrug-resistant tuberculosis (MDR-TB) and extensive drug resistant TB (XDR-TB) as an increasing health problem and a serious challenge to TB control programs. MDR-Tb and XDR-TB are highly lethal in people living with HIV, with case of fatality rates of over 90%. At the same time, there are not many drugs effective in TB chemotherapy. Information about susceptibility patterns of Mycobacterium tuberculosis isolates against antituberculosis drugs is important aspect of tuberculosis control, and surveillance and analysis of local rates of TB drug resistance is helpful in the detection and monitoring of the extent of MDR and XDR strains, indicating the quality of TB control in the country...
May 2011: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Christian Viniol, Claus F Vogelmeier
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. While COPD is a mainly chronic disease, a substantial number of patients suffer from exacerbations. Severe exacerbations are related to a significantly worse survival outcome. This review summarises the current knowledge on the different aspects of COPD exacerbations. The impact of risk factors and triggers such as smoking, severe airflow limitation, bronchiectasis, bacterial and viral infections and comorbidities is discussed...
March 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
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