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Cook County Emergency Medicine Journal Club

Literature from the Cook County Emergency Medicine Journal Club

https://read.qxmd.com/read/29133539/validation-of-the-ottawa-subarachnoid-hemorrhage-rule-in-patients-with-acute-headache
#1
MULTICENTER STUDY
Jeffrey J Perry, Marco L A Sivilotti, Jane Sutherland, Corinne M Hohl, Marcel Émond, Lisa A Calder, Christian Vaillancourt, Venkatesh Thirganasambandamoorthy, Howard Lesiuk, George A Wells, Ian G Stiell
BACKGROUND: We previously derived the Ottawa Subarachnoid Hemorrhage Rule to identify subarachnoid hemorrhage (SAH) in patients with acute headache. Our objective was to validate the rule in a new cohort of consecutive patients who visited an emergency department. METHODS: We conducted a multicentre prospective cohort study at 6 university-affiliated tertiary-care hospital emergency departments in Canada from January 2010 to January 2014. We included alert, neurologically intact adult patients with a headache peaking within 1 hour of onset...
November 13, 2017: Canadian Medical Association Journal: CMAJ
https://read.qxmd.com/read/23388005/effect-of-daily-chlorhexidine-bathing-on-hospital-acquired-infection
#2
RANDOMIZED CONTROLLED TRIAL
Michael W Climo, Deborah S Yokoe, David K Warren, Trish M Perl, Maureen Bolon, Loreen A Herwaldt, Robert A Weinstein, Kent A Sepkowitz, John A Jernigan, Kakotan Sanogo, Edward S Wong
BACKGROUND: Results of previous single-center, observational studies suggest that daily bathing of patients with chlorhexidine may prevent hospital-acquired bloodstream infections and the acquisition of multidrug-resistant organisms (MDROs). METHODS: We conducted a multicenter, cluster-randomized, nonblinded crossover trial to evaluate the effect of daily bathing with chlorhexidine-impregnated washcloths on the acquisition of MDROs and the incidence of hospital-acquired bloodstream infections...
February 7, 2013: New England Journal of Medicine
https://read.qxmd.com/read/28811122/acute-kidney-injury-after-computed-tomography-a-meta-analysis
#3
REVIEW
Ryan D Aycock, Lauren M Westafer, Jennifer L Boxen, Nima Majlesi, Elizabeth M Schoenfeld, Raveendhara R Bannuru
STUDY OBJECTIVE: Computed tomography (CT) is an important imaging modality used in the diagnosis of a variety of disorders. Imaging quality may be improved if intravenous contrast is added, but there is a concern for potential renal injury. Our goal is to perform a meta-analysis to compare the risk of acute kidney injury, need for renal replacement, and total mortality after contrast-enhanced CT versus noncontrast CT. METHODS: We searched MEDLINE (PubMed), the Cochrane Library, CINAHL, Web of Science, ProQuest, and Academic Search Premier for relevant articles...
January 2018: Annals of Emergency Medicine
https://read.qxmd.com/read/29268997/what-to-do-after-you-cut-recommendations-for-abscess-management-in-the-emergency-setting
#4
COMMENT
Michael Gottlieb, Gillian Schmitz, Andrew Grock, Jessica Mason
No abstract text is available yet for this article.
January 2018: Annals of Emergency Medicine
https://read.qxmd.com/read/29789983/principles-of-fluid-management-and-stewardship-in-septic-shock-it-is-time-to-consider-the-four-d-s-and-the-four-phases-of-fluid-therapy
#5
REVIEW
Manu L N G Malbrain, Niels Van Regenmortel, Bernd Saugel, Brecht De Tavernier, Pieter-Jan Van Gaal, Olivier Joannes-Boyau, Jean-Louis Teboul, Todd W Rice, Monty Mythen, Xavier Monnet
In patients with septic shock, the administration of fluids during initial hemodynamic resuscitation remains a major therapeutic challenge. We are faced with many open questions regarding the type, dose and timing of intravenous fluid administration. There are only four major indications for intravenous fluid administration: aside from resuscitation, intravenous fluids have many other uses including maintenance and replacement of total body water and electrolytes, as carriers for medications and for parenteral nutrition...
May 22, 2018: Annals of Intensive Care
https://read.qxmd.com/read/28069483/epinephrine-use-in-older-patients-with-anaphylaxis-clinical-outcomes-and-cardiovascular-complications
#6
MULTICENTER STUDY
Takahisa Kawano, Frank Xavier Scheuermeyer, Robert Stenstrom, Brian H Rowe, Eric Grafstein, Brian Grunau
BACKGROUND: There is little data describing the differences in epinephrine (epi) administration and cardiac complications among older and younger patients with anaphylaxis. METHODS: This retrospective cohort study was conducted at two urban emergency departments (ED) over a 5 year-period, and included adults who met a pre-specified criteria for anaphylaxis. Patients ≥50years of age were defined as "older". Univariate logistic regression was performed to compare the difference in frequency of epi administration between the "older" and "younger" groups...
March 2017: Resuscitation
https://read.qxmd.com/read/28641794/time-to-furosemide-treatment-and-mortality-in-patients-hospitalized-with-acute-heart-failure
#7
MULTICENTER STUDY
Yuya Matsue, Kevin Damman, Adriaan A Voors, Nobuyuki Kagiyama, Tetsuo Yamaguchi, Shunsuke Kuroda, Takahiro Okumura, Keisuke Kida, Atsushi Mizuno, Shogo Oishi, Yasutaka Inuzuka, Eiichi Akiyama, Ryuichi Matsukawa, Kota Kato, Satoshi Suzuki, Takashi Naruke, Kenji Yoshioka, Tatsuya Miyoshi, Yuichi Baba, Masayoshi Yamamoto, Koji Murai, Kazuo Mizutani, Kazuki Yoshida, Takeshi Kitai
BACKGROUND: Acute heart failure (AHF) is a life-threatening disease requiring urgent treatment, including a recommendation for immediate initiation of loop diuretics. OBJECTIVES: The authors prospectively evaluated the association between time-to-diuretic treatment and clinical outcome. METHODS: REALITY-AHF (Registry Focused on Very Early Presentation and Treatment in Emergency Department of Acute Heart Failure) was a prospective, multicenter, observational cohort study that primarily aimed to assess the association between time to loop diuretic treatment and clinical outcome in patients with AHF admitted through the emergency department (ED)...
June 27, 2017: Journal of the American College of Cardiology
https://read.qxmd.com/read/29157532/clinical-manifestations-and-outcomes-of-fluoroquinolone-related-acute-interstitial-nephritis
#8
JOURNAL ARTICLE
Saira Farid, Maryam Mahmood, Omar M Abu Saleh, Abdurrahman Hamadah, Samih H Nasr, Zerelda Esquer Garrigos, Nelson Leung, M Rizwan Sohail
OBJECTIVE: To describe the clinical presentation, diagnosis, and outcomes of patients with biopsy-proven acute interstitial nephritis (AIN) related to fluoroquinolone (FQ) therapy. PATIENT AND METHODS: We conducted a retrospective review of biopsy-proven AIN attributed to FQ use at Mayo Clinic's campus in Rochester, Minnesota, from January 1, 1993, through December 31, 2016. Cases were reviewed by a renal pathologist and attributed to FQ use by an expert nephrologist...
January 2018: Mayo Clinic Proceedings
https://read.qxmd.com/read/28641795/door-to-furosemide-therapy-in-the-ed-new-quality-metric-or-just-a-piece-of-the-puzzle
#9
EDITORIAL
James L Januzzi, G Michael Felker
No abstract text is available yet for this article.
June 27, 2017: Journal of the American College of Cardiology
https://read.qxmd.com/read/29129157/thrombectomy-6-to-24-hours-after-stroke-with-a-mismatch-between-deficit-and-infarct
#10
RANDOMIZED CONTROLLED TRIAL
Raul G Nogueira, Ashutosh P Jadhav, Diogo C Haussen, Alain Bonafe, Ronald F Budzik, Parita Bhuva, Dileep R Yavagal, Marc Ribo, Christophe Cognard, Ricardo A Hanel, Cathy A Sila, Ameer E Hassan, Monica Millan, Elad I Levy, Peter Mitchell, Michael Chen, Joey D English, Qaisar A Shah, Frank L Silver, Vitor M Pereira, Brijesh P Mehta, Blaise W Baxter, Michael G Abraham, Pedro Cardona, Erol Veznedaroglu, Frank R Hellinger, Lei Feng, Jawad F Kirmani, Demetrius K Lopes, Brian T Jankowitz, Michael R Frankel, Vincent Costalat, Nirav A Vora, Albert J Yoo, Amer M Malik, Anthony J Furlan, Marta Rubiera, Amin Aghaebrahim, Jean-Marc Olivot, Wondwossen G Tekle, Ryan Shields, Todd Graves, Roger J Lewis, Wade S Smith, David S Liebeskind, Jeffrey L Saver, Tudor G Jovin
BACKGROUND: The effect of endovascular thrombectomy that is performed more than 6 hours after the onset of ischemic stroke is uncertain. Patients with a clinical deficit that is disproportionately severe relative to the infarct volume may benefit from late thrombectomy. METHODS: We enrolled patients with occlusion of the intracranial internal carotid artery or proximal middle cerebral artery who had last been known to be well 6 to 24 hours earlier and who had a mismatch between the severity of the clinical deficit and the infarct volume, with mismatch criteria defined according to age (<80 years or ≥80 years)...
January 4, 2018: New England Journal of Medicine
https://read.qxmd.com/read/22559856/effectiveness-of-intravenous-lidocaine-versus-intravenous-morphine-for-patients-with-renal-colic-in-the-emergency-department
#11
RANDOMIZED CONTROLLED TRIAL
Hassan Soleimanpour, Kamaleddin Hassanzadeh, Hassan Vaezi, Samad E J Golzari, Robab Mehdizadeh Esfanjani, Maryam Soleimanpour
BACKGROUND: Despite the fact that numerous medications have been introduced to treat renal colic, none has been proven to relieve the pain rapidly and thoroughly. In this study, we aimed at comparing the effects of intravenous lidocaine versus intravenous morphine in patients suffering from renal colic. METHODS: In a prospective randomized double-blind clinical trial performed in the emergency department of Imam Reza educational hospital of Tabriz, Iran, we studied 240 patients, 18-65 years old, who were referred due to renal colic...
May 4, 2012: BMC Urology
https://read.qxmd.com/read/28646590/randomized-controlled-double-blind-trial-comparing-haloperidol-combined-with-conventional-therapy-to-conventional-therapy-alone-in-patients-with-symptomatic-gastroparesis
#12
RANDOMIZED CONTROLLED TRIAL
Carlos J Roldan, Kimberly A Chambers, Linda Paniagua, Sonali Patel, Marylou Cardenas-Turanzas, Yashwant Chathampally
OBJECTIVE: Gastroparesis is a debilitating condition that causes nausea, vomiting, and abdominal pain. Management includes analgesics and antiemetics, but symptoms are often refractory. Haloperidol has been utilized in the palliative care setting for similar symptoms. The study objective was to determine whether haloperidol as an adjunct to conventional therapy would improve symptoms in gastroparesis patients presenting to the emergency department (ED). STUDY DESIGN AND METHODS: This was a randomized, double-blind, placebo-controlled trial of adult ED patients with acute exacerbation of previously diagnosed gastroparesis...
November 2017: Academic Emergency Medicine
https://read.qxmd.com/read/28283340/a-prospective-randomized-double-dummy-trial-comparing-iv-push-low-dose-ketamine-to-short-infusion-of-low-dose-ketamine-for-treatment-of-%C3%A2-pain-in-the-ed
#13
RANDOMIZED CONTROLLED TRIAL
Sergey Motov, Mo Mai, Illya Pushkar, Antonios Likourezos, Jefferson Drapkin, Matthew Yasavolian, Jason Brady, Peter Homel, Christian Fromm
STUDY OBJECTIVE: Compare adverse effects and analgesic efficacy of low-dose ketamine for acute pain in the ED administered either by single intravenous push (IVP) or short infusion (SI). METHODS: Patients 18-65, presenting to ED with acute abdominal, flank, or musculoskeletal pain with initial pain score≥5, were randomized to ketamine 0.3mg/kg by either IVP or SI with placebo double-dummy. Adverse effects were evaluated by Side Effects Rating Scale for Dissociative Anesthetics (SERSDA) and Richmond Agitation-Sedation Scale (RASS) at 5, 15, 30, 60, 90, and 120min post-administration; analgesic efficacy was evaluated by Numerical Rating Scale (NRS)...
August 2017: American Journal of Emergency Medicine
https://read.qxmd.com/read/28118660/association-between-tracheal-intubation-during-adult-in-hospital-cardiac-arrest-and-survival
#14
MULTICENTER STUDY
Lars W Andersen, Asger Granfeldt, Clifton W Callaway, Steven M Bradley, Jasmeet Soar, Jerry P Nolan, Tobias Kurth, Michael W Donnino
IMPORTANCE: Tracheal intubation is common during adult in-hospital cardiac arrest, but little is known about the association between tracheal intubation and survival in this setting. OBJECTIVE: To determine whether tracheal intubation during adult in-hospital cardiac arrest is associated with survival to hospital discharge. DESIGN, SETTING, AND PARTICIPANTS: Observational cohort study of adult patients who had an in-hospital cardiac arrest from January 2000 through December 2014 included in the Get With The Guidelines-Resuscitation registry, a US-based multicenter registry of in-hospital cardiac arrest...
February 7, 2017: JAMA
https://read.qxmd.com/read/29044739/peripheral-intravenous-cannula-insertion-and-use-in-the-emergency-department-an-intervention-study
#15
JOURNAL ARTICLE
Tracey Hawkins, Jaimi H Greenslade, Jessica Suna, Julian Williams, Claire M Rickard, Matthew Jensen, Maria Donohue, Elizabeth Cho, Christopher Van Hise, Diana Egerton-Warburton, Louise Cullen
OBJECTIVES: The objective was to examine cannulation practice and effectiveness of a multimodal intervention to reduce peripheral intravenous cannula (PIVC) insertion in emergency department (ED) patients. METHODS: A prospective before and after study and cost analysis was conducted at a single tertiary ED in Australia. Data were collected 24 hours a day for 2 weeks pre- and post implementation of a multimodal intervention. PIVC placement and utilization within 24 hours were evaluated in all eligible patients...
January 2018: Academic Emergency Medicine
https://read.qxmd.com/read/28921727/hot-off-the-press-embedded-clinical-decision-support-in-electronic-health-record-decreases-use-of-high-cost-imaging-in-the-emergency-department-embed-study
#16
JOURNAL ARTICLE
Corey Heitz, Justin Morgenstern, William K Milne
This longitudinal before/after study of embedded clinical decision rules assessed the effects of clinical decision support on use of common imaging studies. Among high users, rates of computed tomograhy (CT) scan of the brain and CT of the cervical spine were reduced after implementation of embedded clinical decision instruments, while in low users, rates increased. This article summarizes the manuscript and the Skeptics Guide to Emergency Medicine podcast, as well as the ensuing social media/online discussion...
January 2018: Academic Emergency Medicine
https://read.qxmd.com/read/27084420/hot-off-the-press-use-of-shared-decision-making-for-management-of-acute-musculoskeletal-pain-in-older-adults-discharged-from-the-emergency-department
#17
COMMENT
Kevin Cullison, Christopher R Carpenter, William K Milne
No abstract text is available yet for this article.
August 2016: Academic Emergency Medicine
https://read.qxmd.com/read/28791755/emergency-department-use-of-apneic-oxygenation-versus-usual-care-during-rapid-sequence-intubation-a-randomized-controlled-trial-the-endao-trial
#18
RANDOMIZED CONTROLLED TRIAL
Nicholas Caputo, Ben Azan, Rui Domingues, Lee Donner, Mark Fenig, Douglas Fields, Robert Fraser, Karlene Hosford, Richard Iuorio, Marc Kanter, Moira McCarty, Thomas Parry, Andaleeb Raja, Mary Ryan, Blaine Williams, Hemlata Sharma, Daniel Singer, Chris Shields, Sandra Scott, Jason R West
OBJECTIVES: Desaturation leading to hypoxemia may occur during rapid sequence intubation (RSI). Apneic oxygenation (AO) was developed to prevent the occurrence of oxygen desaturation during the apnea period. The purpose of this study was to determine if the application of AO increases the average lowest oxygen saturation during RSI when compared to usual care (UC) in the emergency setting. METHODS: A randomized controlled trial was conducted at an academic, urban, Level I trauma center...
November 2017: Academic Emergency Medicine
https://read.qxmd.com/read/24066745/resuscitation-fluids
#19
REVIEW
John A Myburgh, Michael G Mythen
New England Journal of Medicine, Volume 369, Issue 13, Page 1243-1251, September 2013.
September 26, 2013: New England Journal of Medicine
https://read.qxmd.com/read/25385815/clinical-decision-support-for-early-recognition-of-sepsis
#20
MULTICENTER STUDY
Robert C Amland, Kristin E Hahn-Cover
Sepsis is an inflammatory response triggered by infection, with a high in-hospital mortality rate. Early recognition and treatment can reverse the inflammatory response, with evidence of improved patient outcomes. One challenge clinicians face is identifying the inflammatory syndrome against the background of the patient's infectious illness and comorbidities. An approach to this problem is implementation of computerized early warning tools for sepsis. This multicenter retrospective study sought to determine clinimetric performance of a cloud-based computerized sepsis clinical decision support system (CDS), understand the epidemiology of sepsis, and identify opportunities for quality improvement...
March 2016: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
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