Yongdong Dai, Lulu Liu, Tingting Zeng, Jian-Zhong Liang, Ye Song, Kai Chen, Yan Li, Leilei Chen, Ying-Hui Zhu, Jiangchao Li, Yan Li, Dan Xie, Yun-Fei Yuan, Xin-Yuan Guan
Recently RNA sequencing revealed high mucin 13 (MUC13) expression in hepatocellular carcinoma (HCC) tissues. To understand the clinicopathologic significance of MUC13 in HCC, quantitative PCR and immunohistochemistry were used to detect its expression in paired tumor tissues and nontumor tissues. The oncoprotein role of MUC13 was determined by in vitro and in vivo assays. Overexpression of MUC13 was detected in 74 of 168 primary HCC cases (44%) and was significantly associated with tumor size (P = 0.027), stage (P = 0...
February 2018: American Journal of Pathology