Nik Goyert, Gareth Eeson, Daniel J Kagedan, Ramy Behman, Madeline Lemke, Julie Hallet, Nicole Mittmann, Calvin Law, Paul J Karanicolas, Natalie G Coburn
OBJECTIVE: To determine the cost-effectiveness of perioperative administration of pasireotide for reduction of pancreatic fistula (PF). SUMMARY: PF is a major complication following pancreaticoduodenectomy (PD), associated with significant morbidity and healthcare-related costs. Pasireotide is a novel multireceptor ligand somatostatin analogue, which has been demonstrated to reduce the incidence of PF following pancreas resection; however, the drug cost is significant...
January 2017: Annals of Surgery
Peter J Allen, Mithat Gönen, Murray F Brennan, Adjoa A Bucknor, Lindsay M Robinson, Marisa M Pappas, Kate E Carlucci, Michael I D'Angelica, Ronald P DeMatteo, T Peter Kingham, Yuman Fong, William R Jarnagin
BACKGROUND: Postoperative pancreatic fistula is a major contributor to complications and death associated with pancreatic resection. Pasireotide, a somatostatin analogue that has a longer half-life than octreotide and a broader binding profile, decreases pancreatic exocrine secretions and may prevent postoperative pancreatic fistula. METHODS: We conducted a single-center, randomized, double-blind trial of perioperative subcutaneous pasireotide in patients undergoing either pancreaticoduodenectomy or distal pancreatectomy...
May 22, 2014: New England Journal of Medicine
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