Read by QxMD icon Read

Autophagy Infucing-Peptide

shared collection
1 papers 0 to 25 followers
By Lazaro Garcia flores Neuroendocrino tumor
Sanae Shoji-Kawata, Rhea Sumpter, Matthew Leveno, Grant R Campbell, Zhongju Zou, Lisa Kinch, Angela D Wilkins, Qihua Sun, Kathrin Pallauf, Donna MacDuff, Carlos Huerta, Herbert W Virgin, J Bernd Helms, Ruud Eerland, Sharon A Tooze, Ramnik Xavier, Deborah J Lenschow, Ai Yamamoto, David King, Olivier Lichtarge, Nick V Grishin, Stephen A Spector, Dora V Kaloyanova, Beth Levine
The lysosomal degradation pathway of autophagy has a crucial role in defence against infection, neurodegenerative disorders, cancer and ageing. Accordingly, agents that induce autophagy may have broad therapeutic applications. One approach to developing such agents is to exploit autophagy manipulation strategies used by microbial virulence factors. Here we show that a peptide, Tat-beclin 1-derived from a region of the autophagy protein, beclin 1, which binds human immunodeficiency virus (HIV)-1 Nef-is a potent inducer of autophagy, and interacts with a newly identified negative regulator of autophagy, GAPR-1 (also called GLIPR2)...
February 14, 2013: Nature
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"