collection
https://read.qxmd.com/read/32682486/temporary-circulatory-support-for-cardiogenic-shock
#1
REVIEW
Alain Combes, Susanna Price, Arthur S Slutsky, Daniel Brodie
Cardiogenic shock can occur due to acute ischaemic or non-ischaemic cardiac events, or from progression of long-standing underlying heart disease. When addressing the cause of underlying disease, the management of cardiogenic shock consists of vasopressors and inotropes; however, these agents can increase myocardial oxygen consumption, impair tissue perfusion, and are frequently ineffective. An alternative approach is to temporarily augment cardiac output using mechanical devices. The use of these devices-known as temporary circulatory support systems-has increased substantially in recent years, despite being expensive, resource intensive, associated with major complications, and lacking high-quality evidence to support their use...
July 18, 2020: Lancet
https://read.qxmd.com/read/32339046/evaluation-and-management-of-premature-ventricular-complexes
#2
REVIEW
Gregory M Marcus
Premature ventricular complexes (PVCs) are extremely common, found in the majority of individuals undergoing long-term ambulatory monitoring. Increasing age, a taller height, a higher blood pressure, a history of heart disease, performance of less physical activity, and smoking each predict a greater PVC frequency. Although the fundamental causes of PVCs remain largely unknown, potential mechanisms for any given PVC include triggered activity, automaticity, and reentry. PVCs are commonly asymptomatic but can also result in palpitations, dyspnea, presyncope, and fatigue...
April 28, 2020: Circulation
https://read.qxmd.com/read/32039404/beta-blockers-in-cirrhosis-evidence-based-indications%C3%A2-and%C3%A2-limitations
#3
REVIEW
Susana G Rodrigues, Yuly P Mendoza, Jaime Bosch
Non-selective beta-blockers (NSBBs) are the mainstay of treatment for portal hypertension in the setting of liver cirrhosis. Randomised controlled trials demonstrated their efficacy in preventing initial variceal bleeding and subsequent rebleeding. Recent evidence indicates that NSBBs could prevent liver decompensation in patients with compensated cirrhosis. Despite solid data favouring NSBB use in cirrhosis, some studies have highlighted relevant safety issues in patients with end-stage liver disease, particularly with refractory ascites and infection...
February 2020: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/31958242/the-fourth-universal-definition-of-myocardial-infarction-and-the-emerging-importance-of-myocardial-injury
#4
EDITORIAL
David A Morrow
No abstract text is available yet for this article.
January 21, 2020: Circulation
https://read.qxmd.com/read/31205834/ivabradine-in-congestive-heart-failure-patient-selection-and-perspectives
#5
REVIEW
Yasar Sattar, Elham Neisani Samani, Fnu Zafrullah, Sharaad Latchana, Nirav B Patel
Heart failure (HF) is the fourth-most frequent cause of death and remains a challenge for public health. Therapy goals for HF with reduced ejection fraction (HFrEF) are the improvement in the quality of life, prolonged survival, a reduction of signs and symptoms, and the prevention of hospitalization. Angiotensin-converting enzyme inhibitors, beta-blockers, and mineralocorticoid receptor antagonists are the treatments of choice for HFrEF. Although ivabradine is not available in all countries, it is likely a new promising approach to improve outcomes in patients with HFrEF, either alone or with beta-blockers...
April 13, 2019: Curēus
https://read.qxmd.com/read/31102275/anticoagulation-in-chronic-kidney-disease-from-guidelines-to-clinical-practice
#6
REVIEW
Viviana Aursulesei, Irina Iuliana Costache
BACKGROUND: Chronic kidney disease (CKD) is a major global public health problem, being closely connected to cardiovascular disease. CKD involves an elevated thromboembolic risk and requires anticoagulation, but the high rates of hemorrhage render it quite challenging. HYPOTHESIS: There are no consensus recommendations regarding anticoagulation in CKD. Due to the currently limited data, clinicians need practical clues for monitoring and optimizing the treatment...
August 2019: Clinical Cardiology
https://read.qxmd.com/read/30697449/use-of-direct-oral-anticoagulants-in-daily-practice
#7
REVIEW
Feras Almarshad, Ali Alaklabi, Ebtisam Bakhsh, Aslam Pathan, Mosaad Almegren
In recent years, the options for anticoagulant therapy have examined new direct oral anticoagulants (DOACs) comprising direct thrombin inhibitors (dabigatran) and direct factor Xa inhibitors (rivaroxaban, apixaban, and edoxaban). These agents represent further progress towards the ideal anticoagulant drug and thus towards a safe and effective antithrombotic therapy. The ideal anticoagulant is oral and has a wide therapeutic range, predictable pharmacokinetics and pharmacodynamics, a rapid onset of action, an available antidote, minimal side effects, and minimal interactions with other drugs or food...
2018: American Journal of Blood Research
https://read.qxmd.com/read/29247356/current-and-future-pharmacological-therapies-for-nafld-nash
#8
REVIEW
Yoshio Sumida, Masashi Yoneda
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, and there is no approved pharmacotherapy. The efficacy of vitamin E and pioglitazone has been established in nonalcoholic steatohepatitis (NASH), a progressive form of NAFLD. GLP-1RA and SGLT2 inhibitors, which are currently approved for use in diabetes, have shown early efficacy in NASH, and also have beneficial cardiovascular or renal effects. Innovative NASH therapies include four main pathways. The first approach is targeting hepatic fat accumulation...
March 2018: Journal of Gastroenterology
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