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JOURNAL ARTICLE
Katrin Hefler-Frischmuth, Judith Lafleur, Lukas Hefler, Stephan Polterauer, Veronika Seebacher, Alexander Reinthaller, Christoph Grimm
OBJECTIVE: Plasma fibrinogen is a key acute phase protein and known to be elevated in ovarian cancer. We aimed to investigate the association between plasma fibrinogen and malignant and benign ovarian tumors. METHODS: In a retrospective, single-center study, we evaluated preoperative plasma fibrinogen levels in 471 patients with benign and in 224 patients with malignant (borderline ovarian tumor [BOT]: n=36, epithelial ovarian cancer [EOC]: n=188) ovarian tumors...
March 2015: Gynecologic Oncology
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REVIEW
Christina B Rasmussen, Susanne K Kjaer, Vanna Albieri, Elisa V Bandera, Jennifer A Doherty, Estrid Høgdall, Penelope M Webb, Susan J Jordan, Mary Anne Rossing, Kristine G Wicklund, Marc T Goodman, Francesmary Modugno, Kirsten B Moysich, Roberta B Ness, Robert P Edwards, Joellen M Schildkraut, Andrew Berchuck, Sara H Olson, Lambertus A Kiemeney, Leon F A G Massuger, Steven A Narod, Catherine M Phelan, Hoda Anton-Culver, Argyrios Ziogas, Anna H Wu, Celeste L Pearce, Harvey A Risch, Allan Jensen
Inflammation has been implicated in ovarian carcinogenesis. However, studies investigating the association between pelvic inflammatory disease (PID) and ovarian cancer risk are few and inconsistent. We investigated the association between PID and the risk of epithelial ovarian cancer according to tumor behavior and histotype. We pooled data from 13 case-control studies, conducted between 1989 and 2009, from the Ovarian Cancer Association Consortium (OCAC), including 9,162 women with ovarian cancers, 2,354 women with borderline tumors, and 14,736 control participants...
January 1, 2017: American Journal of Epidemiology
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