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Craig T January, L Samuel Wann, Hugh Calkins, Lin Y Chen, Joaquin E Cigarroa, Joseph C Cleveland, Patrick T Ellinor, Michael D Ezekowitz, Michael E Field, Karen L Furie, Paul A Heidenreich, Katherine T Murray, Julie B Shea, Cynthia M Tracy, Clyde W Yancy
No abstract text is available yet for this article.
January 28, 2019: Circulation
Uffe Ravnskov, Michel de Lorgeril, David M Diamond, Rokuro Hama, Tomohito Hamazaki, Björn Hammarskjöld, Niamh Hynes, Malcolm Kendrick, Peter H Langsjoen, Luca Mascitelli, Kilmer S McCully, Harumi Okuyama, Paul J Rosch, Tore Schersten, Sherif Sultan, Ralf Sundberg
For half a century, a high level of total cholesterol (TC) or low-density lipoprotein cholesterol (LDL-C) has been considered to be the major cause of atherosclerosis and cardiovascular disease (CVD), and statin treatment has been widely promoted for cardiovascular prevention. However, there is an increasing understanding that the mechanisms are more complicated and that statin treatment, in particular when used as primary prevention, is of doubtful benefit. Areas covered: The authors of three large reviews recently published by statin advocates have attempted to validate the current dogma...
October 2018: Expert Review of Clinical Pharmacology
Craig T January, L Samuel Wann, Hugh Calkins, Lin Y Chen, Joaquin E Cigarroa, Joseph C Cleveland, Patrick T Ellinor, Michael D Ezekowitz, Michael E Field, Karen L Furie, Paul A Heidenreich, Katherine T Murray, Julie B Shea, Cynthia M Tracy, Clyde W Yancy
No abstract text is available yet for this article.
January 21, 2019: Journal of the American College of Cardiology
Chiagozie I Pickens, Richard G Wunderink, Chiagozie I Pickens
In the face of emerging drug resistant pathogens and a decrease in the development of new antimicrobial agents, antibiotic stewardship should be practiced in all critical care units. Antibiotic stewardship should be a core competency of all critical care practitioners in conjunction with a formal Antibiotic Stewardship Program (ASP). Prospective audit and feedback, and antibiotic time outs are effective components of an ASP in the ICU. As rapid diagnostics are introduced in the ICU, assessment of performance and effect on outcomes will clearly be needed...
January 25, 2019: Chest
Francesca M Trovato, Liane Rabinowich, Mark J W McPhail
PURPOSE OF REVIEW: This review describes the current intensive care management of acute liver failure (ALF) and the latest evidence for emerging therapies. RECENT FINDINGS: Mortality from ALF continues to improve and in some cases, medical therapy can negate the need for liver transplantation because of protocolized management in specialist centres. Liver transplantation remains the cornerstone of management for poor prognosis ALF. The reduced use of blood products in ALF reflects growing evidence of balanced haemostasis in severe liver disease...
January 28, 2019: Current Opinion in Critical Care
Juliet E Compston, Michael R McClung, William D Leslie
Fractures resulting from osteoporosis become increasingly common in women after age 55 years and men after age 65 years, resulting in substantial bone-associated morbidities, and increased mortality and health-care costs. Research advances have led to a more accurate assessment of fracture risk and have increased the range of therapeutic options available to prevent fractures. Fracture risk algorithms that combine clinical risk factors and bone mineral density are now widely used in clinical practice to target high-risk individuals for treatment...
January 26, 2019: Lancet
Carla Casulo, Paul M Barr
Follicular lymphoma (FL) is the most frequently occurring indolent non-Hodgkin lymphoma with generally favorable outcomes, but a variable clinical course. Recent studies have elucidated the consistent and reproducible frequency of early disease progression in FL, occurring in approximately 20% of patients. Relapse of FL within 24 months of chemoimmunotherapy (POD24) is now established as a robust marker of poor survival, leading to increased risk of death. Currently there is no established method of identifying patients at risk for early disease progression at the time of their FL diagnosis...
January 30, 2019: Blood
Sophie Gosselin
No abstract text is available yet for this article.
January 2019: CJEM
(no author information available yet)
No abstract text is available yet for this article.
February 2019: BJU International
Jennifer Abbasi
No abstract text is available yet for this article.
January 30, 2019: JAMA: the Journal of the American Medical Association
Vittoria Comellini, Angela Maria Grazia Pacilli, Stefano Nava
Non-invasive ventilation (NIV) with bilevel positive airway pressure is a non-invasive technique, which refers to the provision of ventilatory support through the patient's upper airway using a mask or similar device. This technique is successful in correcting hypoventilation. It has become widely accepted as the standard treatment for patients with hypercapnic respiratory failure (HRF). Since the 1980s, NIV has been used in intensive care units and, after initial anecdotal reports and larger series, a number of randomized trials have been conducted...
January 12, 2019: Respirology: Official Journal of the Asian Pacific Society of Respirology
Marin H Kollef, Kevin D Betthauser
PURPOSE OF REVIEW: This review provides the rationale for the development of new antibiotics to treat community-acquired pneumonia (CAP). It also provides an overview of the new antibiotics targeting CAP that have recently received approval by the regulatory agencies, and those antibiotics that are in the development pipeline. RECENT FINDINGS: CAP is one of the most common reasons for hospitalization and carries a significant morbidity and risk of mortality. Increasing antibiotic resistance amongst the common bacterial pathogens associated with CAP, especially staphylococci and Streptococcus pneumoniae, has made the empiric treatment of this infection increasingly problematic...
January 11, 2019: Current Opinion in Infectious Diseases
Ana Catarina Pinho-Gomes, Kazem Rahimi
Hypertension is a common comorbidity in patients with heart failure and most drugs that have demonstrated to improve prognosis in this population have the potential to reduce blood pressure. Nonetheless, the relationship between blood pressure and clinical outcomes and the relevance of blood pressure reduction in heart failure remains unclear. This narrative review summarises the evidence currently available to guide blood pressure treatment in this patient group and highlights key questions for further research...
January 23, 2019: Heart: Official Journal of the British Cardiac Society
Brad H Rovin, Dawn J Caster, Daniel C Cattran, Keisha L Gibson, Jonathan J Hogan, Marcus J Moeller, Dario Roccatello, Michael Cheung, David C Wheeler, Wolfgang C Winkelmayer, Jürgen Floege
In November 2017, the Kidney Disease: Improving Global Outcomes (KDIGO) initiative brought a diverse panel of experts in glomerular diseases together to discuss the 2012 KDIGO glomerulonephritis guideline in the context of new developments and insights that had occurred over the years since its publication. During this KDIGO Controversies Conference on Glomerular Diseases, the group examined data on disease pathogenesis, biomarkers, and treatments to identify areas of consensus and areas of controversy. This report summarizes the discussions on primary podocytopathies, lupus nephritis, anti-neutrophil cytoplasmic antibody-associated nephritis, complement-mediated kidney diseases, and monoclonal gammopathies of renal significance...
February 2019: Kidney International
J A Jeevendra Martyn, Jianren Mao, Edward A Bittner
New England Journal of Medicine, Volume 380, Issue 4, Page 365-378, January 2019.
January 24, 2019: New England Journal of Medicine
Lisa L Strate, Arden M Morris
Diverticulitis is a prevalent gastrointestinal disorder that is associated with significant morbidity and health care costs. Approximately 20% of patients with incident diverticulitis have at least 1 recurrence. Complications of diverticulitis, such as abdominal sepsis, are less likely to occur with subsequent events. Several risk factors, many of which are modifiable, have been identified including obesity, diet, and physical inactivity. Diet and lifestyle factors could affect risk of diverticulitis through their effects on the intestinal microbiome and inflammation...
January 17, 2019: Gastroenterology
Randy L Luciano, Gilbert W Moeckel
The kidney biopsy is an invaluable tool that has become the gold standard for the diagnosis of pathologic kidney diseases since the early 1950s. Throughout the years, immunohistologic and ultrastructural microscopy techniques have improved and provide more information on the cause and classification of kidney diseases than that available from simple light microscopy alone. Kidney biopsy has become a preferred method to obtain critical information that can be used in conjunction with serologic, urinary, and genetic testing to diagnose a variety of kidney diseases, both acute and chronic...
January 17, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Jürgen Floege, Sean J Barbour, Daniel C Cattran, Jonathan J Hogan, Patrick H Nachman, Sydney C W Tang, Jack F M Wetzels, Michael Cheung, David C Wheeler, Wolfgang C Winkelmayer, Brad H Rovin
The Kidney Disease: Improving Global Outcomes (KDIGO) initiative organized a Controversies Conference on glomerular diseases in November 2017. The conference focused on the 2012 KDIGO guideline with the aim of identifying new insights into nomenclature, pathogenesis, diagnostic work-up, and, in particular, therapy of glomerular diseases since the guideline's publication. It was the consensus of the group that most guideline recommendations, in particular those dealing with therapy, will need to be revisited by the guideline-updating Work Group...
February 2019: Kidney International
Thierry Gustot, Rajiv Jalan
The spectrum of alcohol-related liver diseases (ALD) includes steatosis, steatohepatitis, progressive liver fibrosis, and cirrhosis. Acute-on-chronic liver failure (ACLF) is a recently defined entity that occurs in patients with chronic liver diseases and is characterised by acute decompensation, organ failures and a high risk of short-term mortality. Active alcohol consumption, alcoholic hepatitis and bacterial infections are the most frequent events precipitating the development of ACLF in the context of ALD (ALD-ACLF)...
February 2019: Journal of Hepatology
Adel S El-Hennawy, Elena Frolova, Wesley A Romney
Background: There is no ideal lock solution that prevents hemodialysis (HD) catheter loss due to catheter-related thrombosis (CRT) and catheter-related bloodstream infection (CRBSI). Catheter loss is associated with increased hospitalization and high inpatient costs. Sodium bicarbonate (NaHCO3) demonstrates anti-infective and anticoagulation properties with a good safety profile, making it an ideal lock solution development target. The objective of this study was to determine the safety and efficacy of using sodium bicarbonate catheter lock solution (SBCLS) as a means of preventing HD catheter loss due to CRT and CRBSI...
January 21, 2019: Nephrology, Dialysis, Transplantation
2019-02-04 00:24:58
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