Gajanan S Bhat, Anuradha Shastry
BACKGROUND: Orgasm in women is a complex phenomenon, and the sparse data about time to orgasm (TitOr) in women are an impediment to the research on this complex phenomenon. AIM: To evaluate the stopwatch measured TitOr in women in a monogamous stable heterosexual relationship. METHODS: The study was conducted through web-based and personal interview using a questionnaire, which addressed the issues related to TitOr. Sexually active women older than 18 years and women in a monogamous stable heterosexual relationship were included in the study...
April 2020: Journal of Sexual Medicine
Pratik Sinha, Michael A Matthay, Carolyn S Calfee
No abstract text is available yet for this article.
June 30, 2020: JAMA Internal Medicine
Carmen Riggioni, Pasquale Comberiati, Mattia Giovannini, Ioana Agache, Mübeccel Akdis, Magna Alves-Correia, Josep M Antó, Alessandra Arcolaci, Ahmet Kursat Azkur, Dilek Azkur, Burcin Beken, Cristina Boccabella, Jean Bousquet, Heimo Breiteneder, Daniela Carvalho, Leticia De Las Vecillas, Zuzana Diamant, Ibon Eguiluz-Gracia, Thomas Eiwegger, Stefanie Eyerich, Wytske Fokkens, Ya-Dong Gao, Farah Hannachi, Sebastian L Johnston, Marek Jutel, Aspasia Karavelia, Ludger Klimek, Beatriz Moya, Kari Nadeau, Robyn O'Hehir, Liam O'Mahony, Oliver Pfaar, Marek Sanak, Jürgen Schwarze, Milena Sokolowska, María J Torres, Willem van de Veen, Menno C van Zelm, De Yun Wang, Luo Zhang, Rodrigo Jiménez-Saiz, Cezmi A Akdis
In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date it has resulted in ~6.5 million confirmed cases and caused almost 400,000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socio-economic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19...
June 14, 2020: Allergy
Meagan E Deming, Nelson L Michael, Merlin Robb, Myron S Cohen, Kathleen M Neuzil
No abstract text is available yet for this article.
July 1, 2020: New England Journal of Medicine
Kuldeep Dhama, Sharun Khan, Ruchi Tiwari, Shubhankar Sircar, Sudipta Bhat, Yashpal Singh Malik, Karam Pal Singh, Wanpen Chaicumpa, D Katterine Bonilla-Aldana, Alfonso J Rodriguez-Morales
SUMMARYIn recent decades, several new diseases have emerged in different geographical areas, with pathogens including Ebola virus, Zika virus, Nipah virus, and coronaviruses (CoVs). Recently, a new type of viral infection emerged in Wuhan City, China, and initial genomic sequencing data of this virus do not match with previously sequenced CoVs, suggesting a novel CoV strain (2019-nCoV), which has now been termed severe acute respiratory syndrome CoV-2 (SARS-CoV-2). Although coronavirus disease 2019 (COVID-19) is suspected to originate from an animal host (zoonotic origin) followed by human-to-human transmission, the possibility of other routes should not be ruled out...
September 16, 2020: Clinical Microbiology Reviews
Jesus M Banales, Jose J G Marin, Angela Lamarca, Pedro M Rodrigues, Shahid A Khan, Lewis R Roberts, Vincenzo Cardinale, Guido Carpino, Jesper B Andersen, Chiara Braconi, Diego F Calvisi, Maria J Perugorria, Luca Fabris, Luke Boulter, Rocio I R Macias, Eugenio Gaudio, Domenico Alvaro, Sergio A Gradilone, Mario Strazzabosco, Marco Marzioni, Cédric Coulouarn, Laura Fouassier, Chiara Raggi, Pietro Invernizzi, Joachim C Mertens, Anja Moncsek, Sumera Rizvi, Julie Heimbach, Bas Groot Koerkamp, Jordi Bruix, Alejandro Forner, John Bridgewater, Juan W Valle, Gregory J Gores
Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant tumours that can arise at any point of the biliary tree. Their incidence is increasing globally, currently accounting for ~15% of all primary liver cancers and ~3% of gastrointestinal malignancies. The silent presentation of these tumours combined with their highly aggressive nature and refractoriness to chemotherapy contribute to their alarming mortality, representing ~2% of all cancer-related deaths worldwide yearly. The current diagnosis of CCA by non-invasive approaches is not accurate enough, and histological confirmation is necessary...
June 30, 2020: Nature Reviews. Gastroenterology & Hepatology
Maria Prendecki, Stephen P McAdoo
Anti-neutrophil cytoplasm antibody (ANCA)- associated vasculitis (AAV) is a rare systemic auto-immune disease characterised by necrotizing inflammation of predominantly small blood vessels and the presence of circulating ANCA directed against myeloperoxidase (MPO) or proteinase-3 (PR3). Current treatment strategies for severe disease, supported by the findings of several well-coordinated randomised control trials, aim to induce remission with high-dose glucocorticoids and either rituximab or cyclophosphamide, followed by relapse prevention with a period of sustained low-dose treatment...
June 20, 2020: Arthritis & Rheumatology
Jonathan D Mizrahi, Rishi Surana, Juan W Valle, Rachna T Shroff
Pancreatic cancer is a highly fatal disease with a 5-year survival rate of approximately 10% in the USA, and it is becoming an increasingly common cause of cancer mortality. Risk factors for developing pancreatic cancer include family history, obesity, type 2 diabetes, and tobacco use. Patients typically present with advanced disease due to lack of or vague symptoms when the cancer is still localised. High quality computed tomography with intravenous contrast using a dual phase pancreatic protocol is typically the best method to detect a pancreatic tumour and to determine surgical resectability...
June 27, 2020: Lancet
Leora R Feldstein, Erica B Rose, Steven M Horwitz, Jennifer P Collins, Margaret M Newhams, Mary Beth F Son, Jane W Newburger, Lawrence C Kleinman, Sabrina M Heidemann, Amarilis A Martin, Aalok R Singh, Simon Li, Keiko M Tarquinio, Preeti Jaggi, Matthew E Oster, Sheemon P Zackai, Jennifer Gillen, Adam J Ratner, Rowan F Walsh, Julie C Fitzgerald, Michael A Keenaghan, Hussam Alharash, Sule Doymaz, Katharine N Clouser, John S Giuliano, Anjali Gupta, Robert M Parker, Aline B Maddux, Vinod Havalad, Stacy Ramsingh, Hulya Bukulmez, Tamara T Bradford, Lincoln S Smith, Mark W Tenforde, Christopher L Carroll, Becky J Riggs, Shira J Gertz, Ariel Daube, Amanda Lansell, Alvaro Coronado Munoz, Charlotte V Hobbs, Kimberly L Marohn, Natasha B Halasa, Manish M Patel, Adrienne G Randolph
BACKGROUND: Understanding the epidemiology and clinical course of multisystem inflammatory syndrome in children (MIS-C) and its temporal association with coronavirus disease 2019 (Covid-19) is important, given the clinical and public health implications of the syndrome. METHODS: We conducted targeted surveillance for MIS-C from March 15 to May 20, 2020, in pediatric health centers across the United States. The case definition included six criteria: serious illness leading to hospitalization, an age of less than 21 years, fever that lasted for at least 24 hours, laboratory evidence of inflammation, multisystem organ involvement, and evidence of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on reverse-transcriptase polymerase chain reaction (RT-PCR), antibody testing, or exposure to persons with Covid-19 in the past month...
June 29, 2020: New England Journal of Medicine
Steven G Rothrock, David D Cassidy, Mitchell Barneck, Michiel Schinkel, Brian Guetschow, Christiaan Myburgh, Linh Nguyen, Ryan Earwood, Prabath W B Nanayakkara, Rishi S Nannan Panday, Joshua G Briscoe
STUDY OBJECTIVE: Debate exists about the mortality benefit of administering antibiotics within either 1 or 3 hours of sepsis onset. We performed this meta-analysis to analyze the effect of immediate (0 to 1 hour after onset) versus early (1 to 3 hours after onset) antibiotics on mortality in patients with severe sepsis or septic shock. METHODS: This review was consistent with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Searched databases included PubMed, EMBASE, Web of Science, and Cochrane Library, as well as gray literature...
June 24, 2020: Annals of Emergency Medicine
Alison E Thompson, Benjamin L Ranard, Ying Wei, Sanja Jelic
No abstract text is available yet for this article.
June 17, 2020: JAMA Internal Medicine
Muhammad Muneer, Ijaz Akbar
Emergency admissions due to acute metabolic crisis in patients with diabetes remain some of the most common and challenging conditions. DKA (Diabetic Ketoacidosis), HHS (Hyperglycaemic Hyperosmolar State) and recently focused EDKA (Euglycaemic Diabetic Ketoacidosis) are life-threatening different entities. DKA and HHS have distinctly different pathophysiology but basic management protocols are the same. EDKA is just like DKA but without hyperglycaemia. T1D, particularly children are vulnerable to DKA and T2D, particularly elderly with comorbidities are vulnerable to HHS...
June 3, 2020: Advances in Experimental Medicine and Biology
Yan Topilsky
The normal mitral valve is a dynamic structure that permits blood to flow from the left atrial (LA) to left ventricle (LV) during diastole and sealing of the LA from the LV during systole. The main components of the mitral apparatus are the mitral annulus (MA), the mitral leaflets, the chordae tendineae, and the papillary muscles (PM) (Figure 1). Normal valve function is dependent on the integrity and normal interplay of these components. Abnormal function of any one of the components, or their interplay can result in mitral regurgitation (MR)...
2020: Frontiers in Cardiovascular Medicine
Ana Fernández Cruz, Belén Ruiz-Antorán, Elena Múñez Rubio, Aránzazu Sancho López, Alejandro Callejas Díaz, Cristina Avendaño-Solá, Antonio Ramos Martínez
No abstract text is available yet for this article.
June 25, 2020: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Mark Barnes, Paul E Sax
No abstract text is available yet for this article.
June 18, 2020: New England Journal of Medicine
Abrar K Thabit
Biliary tract infections (BTIs), including cholangitis and cholecystitis, are common causes of bacteremia. Bacteremic BTIs are associated with a mortality rate of 9-12%. The extent to which antibiotics are excreted in the bile and the ratio of their exposure to the minimum inhibitory concentration (MIC) of the infecting organism are among the important factors for the treatment of BTIs. The aim of this review is to update healthcare professionals on the distribution of antibiotics in the common bile duct, gallbladder, and gallbladder wall...
June 2, 2020: Pharmacotherapy
Wendy K Chung, Karel Erion, Jose C Florez, Andrew T Hattersley, Marie-France Hivert, Christine G Lee, Mark I McCarthy, John J Nolan, Jill M Norris, Ewan R Pearson, Louis Philipson, Allison T McElvaine, William T Cefalu, Stephen S Rich, Paul W Franks
The convergence of advances in medical science, human biology, data science, and technology has enabled the generation of new insights into the phenotype known as "diabetes." Increased knowledge of this condition has emerged from populations around the world, illuminating the differences in how diabetes presents, its variable prevalence, and how best practice in treatment varies between populations. In parallel, focus has been placed on the development of tools for the application of precision medicine to numerous conditions...
July 2020: Diabetes Care
Julio A Ramirez, Daniel M Musher, Scott E Evans, Charles Dela Cruz, Kristina A Crothers, Chadi A Hage, Stefano Aliberti, Antonio Anzueto, Francisco Arancibia, Forest Arnold, Elie Azoulay, Francesco Blasi, Jose Bordon, Steven Burdette, Bin Cao, Rodrigo Cavallazzi, James Chalmers, Patrick Charles, Jean Chastre, Yann-Erick Claessens, Nathan Dean, Xavier Duval, Muriel Fartoukh, Charles Feldman, Thomas File, Filipe Froes, Stephen Furmanek, Martin Gnoni, Gustavo Lopardo, Carlos Luna, Takaya Maruyama, Rosario Menendez, Mark Metersky, Donna Mildvan, Eric Mortensen, Michael S Niederman, Mathias Pletz, Jordi Rello, Marcos I Restrepo, Yuichiro Shindo, Antoni Torres, Grant Waterer, Brandon Webb, Tobias Welte, Martin Witzenrath, Richard Wunderink
BACKGROUND: Community-acquired pneumonia (CAP) guidelines have improved the management and outcomes of patients with CAP, primarily by standardization of initial empiric therapy. But current society-published guidelines exclude immunocompromised patients. RESEARCH QUESTION: There is no concensus regarding the initial management of immunocompromised patients with suspected CAP. STUDY DESIGN AND METHODS: This consensus document was created by a multidisciplinary panel of 45 physicians with experience in the management of CAP in immunocompromised patients...
June 16, 2020: Chest
J C A Edvinsson, A Viganò, A Alekseeva, E Alieva, R Arruda, C De Luca, N D'Ettore, I Frattale, M Kurnukhina, N Macerola, E Malenkova, M Maiorova, A Novikova, P Řehulka, V Rapaccini, O Roshchina, G Vanderschueren, L Zvaune, A P Andreou, K A Haanes
The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Furthermore, we present the current understanding of several primary headaches, painful neuropathies and their pharmacological treatments...
June 5, 2020: Journal of Headache and Pain
Paul Gabarre, Guillaume Dumas, Thibault Dupont, Michael Darmon, Elie Azoulay, Lara Zafrani
Acute kidney injury (AKI) has been reported in up to 25% of critically-ill patients with SARS-CoV-2 infection, especially in those with underlying comorbidities. AKI is associated with high mortality rates in this setting, especially when renal replacement therapy is required. Several studies have highlighted changes in urinary sediment, including proteinuria and hematuria, and evidence of urinary SARS-CoV-2 excretion, suggesting the presence of a renal reservoir for the virus. The pathophysiology of COVID-19 associated AKI could be related to unspecific mechanisms but also to COVID-specific mechanisms such as direct cellular injury resulting from viral entry through the receptor (ACE2) which is highly expressed in the kidney, an imbalanced renin-angotensin-aldosteron system, pro-inflammatory cytokines elicited by the viral infection and thrombotic events...
June 12, 2020: Intensive Care Medicine
2020-07-07 00:24:59
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