Vinaya Simha
Hypertriglyceridemia is one of the most common lipid abnormalities encountered in clinical practice. Many monogenic disorders causing severe hypertriglyceridemia have been identified, but in most patients triglyceride elevations result from a combination of multiple genetic variations with small effects and environmental factors. Common secondary causes include obesity, uncontrolled diabetes, alcohol misuse, and various commonly used drugs. Correcting these factors and optimizing lifestyle choices, including dietary modification, is important before starting drug treatment...
October 12, 2020: BMJ: British Medical Journal
Jane Han, Adam Faletsky, Arash Mostaghimi
No abstract text is available yet for this article.
September 23, 2020: JAMA Dermatology
Ana Vera Vera Marinho, Francisco Hidalgo, Manuel Pan
No abstract text is available yet for this article.
November 2020: Heart: Official Journal of the British Cardiac Society
Guruprasad P Aithal, Naaventhan Palaniyappan, Louise China, Suvi Härmälä, Lucia Macken, Jennifer M Ryan, Emilie A Wilkes, Kevin Moore, Joanna A Leithead, Peter C Hayes, Alastair J O'Brien, Sumita Verma
The British Society of Gastroenterology in collaboration with British Association for the Study of the Liver has prepared this document. The aim of this guideline is to review and summarise the evidence that guides clinical diagnosis and management of ascites in patients with cirrhosis. Substantial advances have been made in this area since the publication of the last guideline in 2007. These guidelines are based on a comprehensive literature search and comprise systematic reviews in the key areas, including the diagnostic tests, diuretic use, therapeutic paracentesis, use of albumin, transjugular intrahepatic portosystemic stent shunt, spontaneous bacterial peritonitis and beta-blockers in patients with ascites...
October 16, 2020: Gut
Damien Dupont, Jean Menotti, Jean Turc, Charline Miossec, Florent Wallet, Jean-Christophe Richard, Laurent Argaud, Sylvie Paulus, Martine Wallon, Florence Ader, Florence Persat
Occurrence of putative invasive pulmonary aspergillosis was screened in 153 consecutive adult intensive care unit (ICU) patients with respiratory samples addressed for mycological diagnosis during a 6-week period at the emergence of coronavirus disease 2019 (COVID-19) pandemic. Positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) was observed for 106 patients (69.3%). Nineteen of them (17.9%) with positive Aspergillus results were considered as having putative invasive pulmonary aspergillosis...
September 10, 2020: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
John R Petrie, Peter R Rossing, Ian W Campbell
The guidance issued to the pharmaceutical industry by the US Food and Drug Administration in 2008 has led to the publication of a series of randomized, controlled cardiovascular outcomes trials with newer therapeutic classes of glucose-lowering medications. Several of these trials, which evaluated the newer therapeutic classes of sodium-glucose co-transporter-2 inhibitors and glucagon-like peptide-1 receptor agonists, have reported a reduced incidence of major adverse cardiovascular and/or renal outcomes, usually relative to placebo and standard of care...
June 2020: Diabetes, Obesity & Metabolism
Chanu Rhee, Sanjat Kanjilal, Meghan Baker, Michael Klompas
Defining the duration of infectivity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has major implications for public health and infection control practice in healthcare facilities. Early in the pandemic, most hospitals required 2 negative RT-PCR tests before discontinuing isolation in patients with Covid-19. Many patients, however, have persistently positive RT-PCR tests for weeks to months following clinical recovery, and multiple studies now indicate that these generally do not reflect replication-competent virus...
August 25, 2020: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Paolo Spagnolo, Oliver Distler, Christopher J Ryerson, Argyris Tzouvelekis, Joyce S Lee, Francesco Bonella, Demosthenes Bouros, Anna-Maria Hoffmann-Vold, Bruno Crestani, Eric L Matteson
Interstitial lung diseases (ILDs), which can arise from a broad spectrum of distinct aetiologies, can manifest as a pulmonary complication of an underlying autoimmune and connective tissue disease (CTD-ILD), such as rheumatoid arthritis-ILD and systemic sclerosis (SSc-ILD). Patients with clinically distinct ILDs, whether CTD-related or not, can exhibit a pattern of common clinical disease behaviour (declining lung function, worsening respiratory symptoms and higher mortality), attributable to progressive fibrosis in the lungs...
October 9, 2020: Annals of the Rheumatic Diseases
Carsten Tschöpe, Enrico Ammirati, Biykem Bozkurt, Alida L P Caforio, Leslie T Cooper, Stephan B Felix, Joshua M Hare, Bettina Heidecker, Stephane Heymans, Norbert Hübner, Sebastian Kelle, Karin Klingel, Henrike Maatz, Abdul S Parwani, Frank Spillmann, Randall C Starling, Hiroyuki Tsutsui, Petar Seferovic, Sophie Van Linthout
Inflammatory cardiomyopathy, characterized by inflammatory cell infiltration into the myocardium and a high risk of deteriorating cardiac function, has a heterogeneous aetiology. Inflammatory cardiomyopathy is predominantly mediated by viral infection, but can also be induced by bacterial, protozoal or fungal infections as well as a wide variety of toxic substances and drugs and systemic immune-mediated diseases. Despite extensive research, inflammatory cardiomyopathy complicated by left ventricular dysfunction, heart failure or arrhythmia is associated with a poor prognosis...
October 12, 2020: Nature Reviews. Cardiology
Sanskriti Sasikumar, Jonathan A Micieli, Jiwon Oh
No abstract text is available yet for this article.
October 12, 2020: Neurology
Steven Karceski
No abstract text is available yet for this article.
September 29, 2020: Neurology
George W Williams, Nathaniel K Berg, Alexander Reskallah, Xiaoyi Yuan, Holger K Eltzschig
No abstract text is available yet for this article.
October 5, 2020: Anesthesiology
Mario Cazzola
New England Journal of Medicine, Volume 383, Issue 14, Page 1358-1374, October 2020.
October 1, 2020: New England Journal of Medicine
Clifford L Freeman, Christopher S Evans, Tyler W Barrett
Managing sedation in the ventilated emergency department (ED) patient is increasingly important as critical care unit admissions from EDs increase and hospital crowding results in intubated patients boarding for longer periods. The objectives of this review are 3-fold; (1) describe the historical perspective of how sedation of the ventilated patient has changed, (2) summarize the most commonly used sedation and analgesic agents, and (3) provide a practical approach to sedation and analgesia in mechanically ventilated ED patients...
June 2020: Journal of the American College of Emergency Physicians open
Garrett Barry, Vishal Uppal
No abstract text is available yet for this article.
October 6, 2020: Canadian Journal of Anaesthesia
Alexander E Kostyunin, Arseniy E Yuzhalin, Maria A Rezvova, Evgeniy A Ovcharenko, Tatiana V Glushkova, Anton G Kutikhin
The implantation of bioprosthetic heart valves (BHVs) is increasingly becoming the treatment of choice in patients requiring heart valve replacement surgery. Unlike mechanical heart valves, BHVs are less thrombogenic and exhibit superior hemodynamic properties. However, BHVs are prone to structural valve degeneration (SVD), an unavoidable condition limiting graft durability. Mechanisms underlying SVD are incompletely understood, and early concepts suggesting the purely degenerative nature of this process are now considered oversimplified...
September 21, 2020: Journal of the American Heart Association
Thomas L Ortel, Ignacio Neumann, Walter Ageno, Rebecca Beyth, Nathan P Clark, Adam Cuker, Barbara A Hutten, Michael R Jaff, Veena Manja, Sam Schulman, Caitlin Thurston, Suresh Vedantham, Peter Verhamme, Daniel M Witt, Ivan D Florez, Ariel Izcovich, Robby Nieuwlaat, Stephanie Ross, Holger J Schünemann, Wojtek Wiercioch, Yuan Zhang, Yuqing Zhang
BACKGROUND: Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), occurs in ∼1 to 2 individuals per 1000 each year, corresponding to ∼300 000 to 600 000 events in the United States annually. OBJECTIVE: These evidence-based guidelines from the American Society of Hematology (ASH) intend to support patients, clinicians, and others in decisions about treatment of VTE. METHODS: ASH formed a multidisciplinary guideline panel balanced to minimize potential bias from conflicts of interest...
October 13, 2020: Blood Advances
Gregoire Longchamp, Ziad Abbassi, Jeremy Meyer, Christian Toso, Nicolas C Buchs, Frederic Ris
PURPOSE: Fifteen percent of patients undergoing elective sigmoidectomy will present a diverticulitis recurrence, which is associated with significant costs and morbidity. We aimed to systematically review the risk factors associated with recurrence after elective sigmoidectomy. METHODS: PubMed/MEDLINE, Embase, Cochrane, and Web of Science were searched for studies published until May 1, 2020. Original studies were included if (i) they included patients undergoing sigmoidectomy for diverticular disease, (ii) they reported postoperative recurrent diverticulitis, and (iii) they analyzed ≥ 1 variable associated with recurrence...
September 28, 2020: International Journal of Colorectal Disease
Peter Horby, Marion Mafham, Louise Linsell, Jennifer L Bell, Natalie Staplin, Jonathan R Emberson, Martin Wiselka, Andrew Ustianowski, Einas Elmahi, Benjamin Prudon, Tony Whitehouse, Timothy Felton, John Williams, Jakki Faccenda, Jonathan Underwood, J Kenneth Baillie, Lucy C Chappell, Saul N Faust, Thomas Jaki, Katie Jeffery, Wei Shen Lim, Alan Montgomery, Kathryn Rowan, Joel Tarning, James A Watson, Nicholas J White, Edmund Juszczak, Richard Haynes, Martin J Landray
BACKGROUND: Hydroxychloroquine and chloroquine have been proposed as treatments for coronavirus disease 2019 (Covid-19) on the basis of in vitro activity and data from uncontrolled studies and small, randomized trials. METHODS: In this randomized, controlled, open-label platform trial comparing a range of possible treatments with usual care in patients hospitalized with Covid-19, we randomly assigned 1561 patients to receive hydroxychloroquine and 3155 to receive usual care...
October 8, 2020: New England Journal of Medicine
Dominique J McConnachie, Jennifer L Stow, Andrew J Mallett
Primary cilia are specialized sensory organelles that protrude from the apical surface of most cell types. Over the past two decades, they have been found to play important roles in tissue development and signal transduction, with mutations in ciliary-associated proteins resulting in a group of diseases collectively known as ciliopathies. Many of these mutations manifest as renal ciliopathies, characterized by kidney dysfunction resulting from aberrant cilia or ciliary functions. This group of overlapping and genetically heterogeneous diseases includes polycystic kidney disease (PKD), nephronophthisis (NPHP) and Bardet-Biedl syndrome (BBS) as the main focus of this review...
October 8, 2020: American Journal of Kidney Diseases
2020-10-20 00:24:58
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