collection
https://read.qxmd.com/read/23102885/moderate-pulmonary-embolism-treated-with-thrombolysis-from-the-mopett-trial
#1
RANDOMIZED CONTROLLED TRIAL
Mohsen Sharifi, Curt Bay, Laura Skrocki, Farnoosh Rahimi, Mahshid Mehdipour
The role of low-dose thrombolysis in the reduction of pulmonary artery pressure in moderate pulmonary embolism (PE) has not been investigated. Because the lungs are very sensitive to thrombolysis, we postulated that effective and safe thrombolysis might be achieved by a lower dose of tissue plasminogen activator. The purpose of the present study was to evaluate the role of this "safe dose" thrombolysis in the reduction of pulmonary artery pressure in moderate PE. During a 22-month period, 121 patients with moderate PE were randomized to receive a "safe dose" of tissue plasminogen activator plus anticoagulation (thrombolysis group [TG], n = 61 patients) or anticoagulation alone (control group [CG], n = 60)...
January 15, 2013: American Journal of Cardiology
https://read.qxmd.com/read/19741062/efficacy-and-safety-of-low-dose-recombinant-tissue-type-plasminogen-activator-for-the-treatment-of-acute-pulmonary-thromboembolism-a-randomized-multicenter-controlled-trial
#2
RANDOMIZED CONTROLLED TRIAL
Chen Wang, Zhenguo Zhai, Yuanhua Yang, Qi Wu, Zhaozhong Cheng, Lirong Liang, Huaping Dai, Kewu Huang, Weixuan Lu, Zhonghe Zhang, Xiansheng Cheng, Ying H Shen
BACKGROUND: Optimal dosing of the recombinant tissue-type plasminogen activator (rt-PA) is important in treating pulmonary thromboembolism (PTE). The aim of this study was to compare the efficacy and safety of a 50 mg/2 h rt-PA regimen with a 100 mg/2 h rt-PA regimen in patients with acute PTE. METHODS: A prospective, randomized, multicenter trial was conducted in which 118 patients with acute PTE and either hemodynamic instability or massive pulmonary artery obstruction were randomly assigned to receive a treatment regiment of either rt-PA at 50 mg/2 h (n = 65) or 100 mg/2 h (n = 53)...
February 2010: Chest
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