#1
JOURNAL ARTICLE
Cuihong Zhang, Jing Ning, Jianwen Cai, James E Squires, Steven H Belle, Ruosha Li
Modeling disease risk and survival using longitudinal risk factor trajectories is of interest in various clinical scenarios. The capacity to build a prognostic model using the trajectories of multiple longitudinal risk factors, in the presence of potential dependent censoring, would enable more informed, personalized decision making. A dynamic risk score modeling framework is proposed for multiple longitudinal risk factors and survival in the presence of dependent censoring, where both events depend on participants' post-baseline clinical progression and form a competing risks structure...
January 2024: Computational Statistics & Data Analysis
#2
JOURNAL ARTICLE
Denise C Hasson, Shruthi Mohan, James E Rose, Kyle A Merrill, Stuart L Goldstein, Stefanie W Benoit, Charles D Varnell
BACKGROUND: Abnormal serum magnesium (Mg) concentrations are common and associated with worse mortality in kidney-transplant recipients. Many kidney and transplant-related factors affect Mg homeostasis. The concentration of the active form, ionized Mg (iMg), is not measured clinically, and total Mg (tMg) and iMg correlations have conflicted. We hypothesized that iMg and tMg concentrations show poor categorical agreement (i.e., low, normal, and high) in kidney-transplant recipients but that ionized calcium (iCa) correlates with iMg...
January 1, 2024: Annals of Laboratory Medicine
#3
JOURNAL ARTICLE
Kainan Zhang, Xizhou An, Yao Zhu, Lan Huang, Xinyuan Yao, Xing Zeng, Shaoyan Liang, Jie Yu
Acute myeloid leukemia (AML) is a hematological malignancy that commonly occurs in children. The prognosis of pediatric AML is relatively poor, thus threatening the patient's survival. The aberrant expression of the axon guidance factor, netrin-1, is observed in various types of malignancies, and it participates in the proliferation and apoptosis of tumor cells. Herein, we aimed to explore the role of netrin-1 in AML cells. Netrin-1 is highly expressed in AML patients. Proliferation and anti-apoptosis were observed in AML cells treated with netrin-1...
December 31, 2023: Cancer Biology & Therapy
#4
JOURNAL ARTICLE
Litjen L J Tan, Marco Aurelio P Safadi, Michael Horn, Cristina Regojo Balboa, Elena Moya, Jamie Schanbaum, Pedro Pimenta, Emma Lambert, Lamine Soumahoro, Woo-Yun Sohn, Teresa Bruce, Yara Ruiz García
Invasive meningococcal disease is a life-threatening infection preventable through vaccination. Pediatric vaccination rates have declined during the coronavirus disease 2019 (COVID-19) pandemic. This survey aimed to understand how parents' attitudes and behaviors have changed during the pandemic with regard to immunization and, more specifically, meningococcal vaccination. An online survey was emailed to parents of eligible children 0-4 years, following the selection process from UK, France, Germany, Italy, Brazil, Argentina, and Australia; and of adolescents 11-18 years from US...
December 31, 2023: Human Vaccines & Immunotherapeutics
#5
JOURNAL ARTICLE
Hamit Ozyurek, Pinar Altiaylik Ozer, Rohat Oztepeli, Gokce Saygi Uysal
INTRODUCTION Visual snow (VS) is a rare condition that is characterized by continuous dynamically flickering dots in the entire visual field that imitate the 'static' or 'snow' of an analogue television set that is not connected to the antenna (1). VS was first described in 3 of 10 migraineurs patients who presented with a spectrum of positive visual symptoms (2). The symptoms of VS can persist for many years. Although VS might be expressed in patients with migraine as visual aura, persistent VS has been accepted as a distinct clinical entity and termed as visual snow syndrome (VSS) independently from migraine...
December 30, 2023: Acta Neurologica Taiwanica
#6
JOURNAL ARTICLE
Mitsuhiro Kono, Yasuaki Nagami, Tatsuo Nakaoka, Akifumi Matsuki, Masaki Ominami, Shusei Fukunaga, Yasuhiro Fujiwara
No abstract text is available yet for this article.
December 2023: Endoscopy
#7
JOURNAL ARTICLE
Koichi Soga, Shun Takakura, Junki Yumoto
No abstract text is available yet for this article.
December 2023: Endoscopy
#8
JOURNAL ARTICLE
Nimisha Bajaj, James Phelan, Erin E McConnell, Suzanne M Reed
BACKGROUND: Burnout in pediatric residents is widespread. Certain factors are associated with decreased burnout, such as empathy, self-compassion, mindfulness, and resilience, while perceived stress is associated with increased burnout. Narrative medicine may reduce burnout by its impact on protective and exacerbating factors and can be an active tool to promote wellness. The objective of this pilot study was to evaluate immediate and delayed benefits of a longitudinal narrative medicine intervention for pediatric residents using qualitative and quantitative measures...
December 2023: Annals of Medicine
#9
JOURNAL ARTICLE
Rihab H Al-Khalil, Batla S Al-Sowayan, Bayan Albdah
OBJECTIVE: This study examines the impact of the COVID-19 pandemic on cochlear implantation (CI) recipients in Saudi Arabia. The impact was measured using the results of an online survey that investigated challenges related to access to re/habilitation and programming services, increased dependence on virtual interaction, and emotional impact. METHODS: The cross-sectional online survey reached 353 pediatric and adult CI recipients between April 21st and May 3rd 2020, during the first weeks of implementing the lockdown strategy and the transitioning to virtual settings...
December 2023: Annals of Medicine
#10
JOURNAL ARTICLE
Tiewei Li, Xiaojuan Li, Zhiwei Zhu, Xinrui Liu, Geng Dong, Zhe Xu, Min Zhang, Ying Zhou, Jianwei Yang, Junmei Yang, Panpan Fang, Xiaoliang Qiao
BACKGROUND: It is possible that neonates with pneumonia also have unrecognized sepsis. Identifying sepsis in neonates with pneumonia may cause some trouble for clinicians. This study aimed to evaluate the clinical value of the procalcitonin-to-albumin ratio (PAR) in identifying sepsis in neonates with pneumonia. METHODS: We retrospectively included 912 neonates with pneumonia from January 2016 to July 2021. Clinical and laboratory data were collected from electronic medical records...
December 2023: Annals of Medicine
#11
RANDOMIZED CONTROLLED TRIAL
Afnan Essam Masoud, Afaf Ahmed Mohamed Shaheen, Maha Fahad Algabbani, Enas AlEisa, Amani AlKofide
BACKGROUND: Little is known about the effectiveness of the newly emerging technology of exergaming in reducing Cancer Related Fatigue (CRF). OBJECTIVES: The study's primary aim was to examine the effectiveness of exergaming in reducing CRF; the secondary aims were to improve functional capacity/endurance and promote physical activity (PA) among children with acute lymphoblastic leukemia (ALL). METHODS: In this Randomized Controlled Trial (RCT), 45 children aged 6-14 years were randomly assigned into group-I, n = 22, and group II, n = 23...
December 2023: Annals of Medicine
#12
JOURNAL ARTICLE
Elisa Montaguti, Valentina Gesuete, Antonella Perolo, Anna Balducci, Marta Fiorentini, Andrea Donti, Gianluigi Pilu
We report the case of a massive fetal cardiac rhabdomyoma recently occurred at our clinic. A woman at 23 weeks of gestational age was referred to our center for a fetal cardiac echogenic mass of 26 mm detected at the second-trimester screening ultrasound. During pregnancy, though, the mass progressively increased its dimensions until reaching 48 mm in diameter at 37 weeks of gestation. Fetal echoencephalography and brain magnetic resonance did not show any further fetal anomalies, but molecular genetic testing at amniocentesis revealed a heterozygotic missense variant of gene TSC2 associated with Tuberous Sclerosis...
December 2023: Journal of Maternal-fetal & Neonatal Medicine
#13
JOURNAL ARTICLE
Persistent occiput posterior position: predictive factors of spontaneous rotation of the fetal head.
Thomas Parsy, Celia Bettiol, Fabien Vidal, Mickaël Allouche, Lola Loussert-Chambre, Paul Guerby
OBJECTIVES: To assess factors associated with spontaneous rotation in the occiput anterior position for fetuses in persistent occiput posterior (OP) during the second stage of labor. To evaluate maternal and fetal outcomes after spontaneous rotation of persistent OP. METHODS: This is a prospective cohort of 495 women with fetuses in persistent OP position, confirmed with ultrasonography during the second stage of labor. We performed simple logistic regressions, followed by multiple logistic regressions...
December 2023: Journal of Maternal-fetal & Neonatal Medicine
#14
JOURNAL ARTICLE
Angela Paladini, Vito D'Andrea, Anthea Bottoni, Velia Purcaro, Giorgia Prontera, Simonetta Costa, Giovanni Vento
Pericardial effusion (PE) in pediatric population can be asymptomatic or a life-threatening event. Reports on neonates or preterm infants are scarce and generally related to pericardiocentesis of large amounts of PE in emergency situations.We describe a diagnostic pericardiocentesis in a preterm infant with small and loculated pericardial effusion and suspected cardiac mass. We used an ultrasound-guided long-axis in-plane pericardiocentesis technique, with a needle-cannula. The operator obtained a subxiphoid pericardial effusion view with a high frequency linear probe and entered the skin below the tip of the xiphoid process with a 20-gauge closed IV needle-cannula (ViaValve®)...
December 2023: Journal of Maternal-fetal & Neonatal Medicine
#15
JOURNAL ARTICLE
Ylenia Bartolacelli, Daniela Palleri, Anna Balducci, Luca Ragni, Tammam Hasan, Simone Bonetti, Gabriele Egidy Assenza, Maria Elisabetta Mariucci, Marianna Fabi, Emanuela Angeli, Gaetano Domenico Gargiulo, Andrea Donti
INTRODUCTION: The evaluation of upcoming Aortic Coarctation (CoA) in new-borns with prenatal suspicion entails a close echocardiographic monitor until Arterial Duct (AD) closure, in a department with pediatric cardiological and surgical expertise. The significant number of false-positive prenatal diagnoses causes parental stress and healthcare costs. AIM: The aim of this study was to elaborate an echocardiographic prediction model to be employed at birth when PDA is still present, in patients suspected of CoA during fetal life in order to foretell CoA requiring neonatal surgical intervention...
December 2023: Journal of Maternal-fetal & Neonatal Medicine
#16
JOURNAL ARTICLE
Lisa P van der Rijst, Annet van Royen-Kerkhof, Suzanne G M A Pasmans, Renske Schappin, Marjolein S de Bruin-Weller, Marlies de Graaf
Biologicals are becoming increasingly important in the therapeutic landscape of pediatric patients with moderate-to-severe atopic dermatitis (AD). Currently, dupilumab and tralokinumab are registered for the treatment of moderate-to-severe AD, and novel biologicals are expected to follow. Dupilumab was the first biological registered for AD in pediatric patients and was recently approved for patients aged six months to five years. Current and emerging biologicals may address the unmet need for effective and safe treatment options for pediatric AD patients, however, little is known about the practical implementation of biologicals in infants and preschoolers (aged <6 years), including the timing of treatment initiation, discontinuation, and long-term administration of the subcutaneous injections...
December 2023: Journal of Dermatological Treatment
#17
JOURNAL ARTICLE
Erika Obikane, Daisuke Nishi, Naho Morisaki, Takahiro Tabuchi
PURPOSE: The study aims to investigate risk factors of paternal perinatal depression during the COVID-19 pandemic. METHODS: We conducted an online cross-sectional study of 473 prenatal fathers and 1246 postnatal fathers in August 2021. We applied a modified Poisson regression to estimate relative risk ratios of possible factors for paternal perinatal depression (measured by Edinburgh Postnatal Depression Scale), sequentially introducing the following factors into the model: individual factors, interpersonal factors, obstetric/pediatric factors, and service utilization factors...
December 2023: Journal of Psychosomatic Obstetrics and Gynaecology
#18
JOURNAL ARTICLE
Katlyn Droke, Nathanial Bartosek, Haley Kopkau, Molly Stanford, Connor Dyer, Madeleine Hoke, Beth Bailey
Background: Early studies assessing peripartum mood disorders during the COVID-19 pandemic have conflicting results. Objective: The primary aim was to examine if postpartum depression (PPD) was more common or more severe during the COVID-19 pandemic compared to earlier periods, and to assess what individual factors may worsen the impact of the pandemic. Methods: Electronic health records at an academic pediatric practice in Michigan identified 242 biological mother-child dyads with delivery between 1/1/2017 and 12/31/2021...
December 2023: Journal of Psychosomatic Obstetrics and Gynaecology
#19
JOURNAL ARTICLE
Noemi Del Toro-Cisneros, Nathan Berman-Parks, Adela Uribe-Pérez, Adrián E Caballero-Islas, Olynka Vega-Vega
BACKGROUND: The renal angina index (RAI) is a tool that has been validated by several studies in the pediatric population to predict the development of severe acute kidney injury (AKI). The aims of this study were to evaluate the efficacy of the RAI in predicting severe AKI in critically ill patients with COVID-19 and to propose a modified RAI (mRAI) for this population. METHODS: This was a prospective cohort analysis of all COVID-19 patients receiving invasive mechanical ventilation (IMV) who were admitted to the intensive care unit (ICU) of a third-level hospital in Mexico City from 03/2020 to 01/2021...
December 2023: Renal Failure
#20
JOURNAL ARTICLE
Tatsuhiko Azegami, Noriyuki Kounoue, Tadashi Sofue, Masahiko Yazawa, Makoto Tsujita, Kosuke Masutani, Yuki Kataoka, Hideyo Oguchi
BACKGROUND: Pre-emptive kidney transplantation (PEKT), i.e., transplantation performed before initiation of maintenance dialysis, is considered an ideal renal replacement therapy because there is no exposure to long-term dialysis therapy. Therefore, we summarized advantages/disadvantages of PEKT to assist in deciding whether kidney transplantation should be performed pre-emptively. METHODS: This study was registered with PROSPERO, CRD42021269163. Observational studies comparing clinical outcomes between PEKT and non-PEKT were included; those involving only pediatric recipients or simultaneous multi-organ transplantations were excluded...
December 2023: Renal Failure
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