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Maryam Raoofi Nejad, Elham Siasi, Mohammad Amin Abdollahifar, Abbas Aliaghaei, Elham Siasi
Cerebellar ataxia (CA) is a condition in which cerebellar dysfunction results in movement disorders such as dysmetria, synergy and dysdiadochokinesia. This study investigates the therapeutic effects of elderberry (EB) diet on the 3-acetylpyridine-induced (3-AP) CA rat model. First, CA rat models were generated by 3-AP administration followed by elderberry diet treatment containing 2% EB for 8 consecutive weeks. Motor performance, electromyographic activity and gene expression were then evaluated. The number of Purkinje neurons were evaluated by stereological methods...
February 22, 2024: Journal of Chemical Neuroanatomy
Irit Schwartz Nadam, Aouatef Bellamine, Rafael Salom, Sonia Guilera, A M Inarejos-Garcia, Giora Pillar
OBJECTIVES: "WKUP GT", a low caffeine beverage consisting of carob, Guarana, Green Tea and Elderberry extracts was studied on attention and cognitive functions post-lunch in a pilot randomized double blind placebo controlled trial. METHODS: Thirty healthy volunteers were included in a crossover design trial, presenting five beverages randomly assigned to the following groups: placebo, "WKUP GT" (single, double or triple doses), or "caffeine" as an active control...
February 17, 2024: Human Psychopharmacology
Giorgio Cappellucci, Giulia Baini, Elisabetta Miraldi, Lara Pauletto, Heide De Togni, Floriana Raso, Marco Biagi
Several herbal and other natural products are used as ingredients in food supplements to strengthen immunity even if, very often, marketed products are proposed without a clear rationale or experimental evidence. In this study, we aimed to investigate the effect on human monocytes (THP-1) and on ex vivo human peripheral blood mononuclear cells (PBMC) of two formulations, one containing Bifidobacterium animalis subsp . lactis Bl-04® with β-glucans (for adults) and one containing Lactobacillus rhamnosus CRL1505 with elderberry extract (for children)...
February 1, 2024: Foods (Basel, Switzerland)
Olena Stabnikova, Viktor Stabnikov, Octavio Paredes-López
Cultivated fruits and berries, such as raspberries, strawberries, black currants, cherries, blueberries, are generally recognized sources of antioxidants, vitamins, minerals, and other substances beneficial to human health and well-being. However, there are also wild berries and fruits that are of undoubted interest as food products having valuable medicinal properties due to the presence of phenolic compounds, antioxidants, and vitamins. These fruits have a great potential to be used in functional food making...
January 27, 2024: Plant Foods for Human Nutrition
Anca Sandu-Bălan Tăbăcariu, Irina-Loredana Ifrim, Oana-Irina Patriciu, Ioana-Adriana Ștefănescu, Adriana-Luminița Fînaru
A current alternative for sustainable development through green chemistry is the replacement of synthetic compounds with natural ones through the superior capitalization of natural resources, with numerous applications in different fields. The benefits of walnuts ( Juglans regia L.) and elderberries ( Sambucus nigra L.) have been known since ancient times, due to the presence of phytochemicals such as flavonoids, polyphenols, carotenoids, alkaloids, nitrogen-containing compounds, tannins, steroids, anthocyanins, etc...
January 19, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Muge Tokuc, Elif Yazan Sukur
OBJECTIVES: White spot lesions (WSLs) are more susceptible to staining agents due to their porous structure. This study examines the impact of WSL treatments on discoloration caused by pediatric supplements. METHOD AND MATERIALS: Three treatments (fluoride, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), resin infiltration (RI)), a control, and their respective syrup-based subgroups (iron and black elderberry syrups) were established, each with 8 teeth...
January 15, 2024: Quintessence International
Katherine Uhl, Alyson E Mitchell
Elderberry, the fruit of Sambucus nigra , has become a popular inclusion in foods, beverages, supplements, and more in recent years. Although the European subspecies, S . nigra ssp. nigra , has been widely studied for its composition, particularly for phenolic and volatile profiles, other subspecies, such as the American elderberry S . nigra ssp. canadensis and the blue elderberry S . nigra ssp. cerulea , have also become contenders in the elderberry supply chain. For the first time, the composition (including micronutrients, macronutrients, organic acids, titratable acid, soluble solids, phenolic compounds, and cyanogenic glycosides) of these three subspecies of elderberry is compared, highlighting the unique qualities of each subspecies and identifying gaps in the available data on the three subspecies...
January 11, 2024: Annual Review of Food Science and Technology
Hadiseh Jahanbakhshi, Meysam Hassani Moghaddam, Mojtaba Sani, Siavash Parvardeh, Mahdi Eskandarian Boroujeni, Kimia Vakili, Mobina Fathi, Helia Azimi, Maryam Mehranpour, Mohammad-Amin Abdollahifar, Shiva Ghafghazi, Maryam Sadidi, Abbas Aliaghaei, Amir-Hossein Bayat, Ali Asghar Peyvandi
This study evaluates whether elderberry (EB) effectively decreases the inflammation and oxidative stress in the brain cells to reduce Aβ toxicity. In the Aβ + EB group, EB powder was added to rats' routine diet for eight consecutive weeks. Then, spatial memory, working memory, and long-term memory, were measured using the Morris water maze, T-maze, and passive avoidance test. Also, in this investigation immunohistopathology, distribution of hippocampal cells, and gene expression was carried out...
December 2023: Toxicology Research
Daniela Mendes, Francisco Peixoto, Maria Manuel Oliveira, Paula Branquinho Andrade, Romeu António Videira
The development of new therapeutic options for Parkinson's disease (PD) requires formulations able to mitigate both brain degeneration and motor dysfunctions. SC- Nanophytosomes, an oral mitochondria-targeted formulation developed with Codium tomentosum membrane polar lipids and elderberry anthocyanin-enriched extract, promote significant brain benefits on a rotenone-induced rat model of PD. In the present work, the effects of SC- Nanophytosome treatment on the skeletal muscle tissues are disclosed. It is unveiled that the rotenone-induced PD rat model exhibits motor disabilities and skeletal muscle tissues with deficient activity of mitochondrial complexes I and II along with small changes in antioxidant enzyme activity and skeletal muscle lipidome...
November 27, 2023: International Journal of Molecular Sciences
Rubén Domínguez-Valencia, Aurora Cittadini, Mirian Pateiro, Paulo E S Munekata, José M Lorenzo
There are few studies on the use of elderberry in the food industry, and its form of application differs between the different studies. Therefore, the objective of this study is to describe a procedure for obtaining a stabilized product with a high content of hydrophilic bioactive compounds (encapsulated elderberry extract). Moreover, the solid residue resulting from the extraction of the polyphenols was characterized, and the lipophilic compounds retained in this residue were analyzed. The results show an important antioxidant activity of the extracts obtained, mainly linked to the high content of anthocyanins, hydroxycinnamic acids, and flavonols...
November 23, 2023: Foods (Basel, Switzerland)
Cornelia Schmutz, Frank Will, Elisabeth Varga, Carola Jaunecker, Gudrun Pahlke, Walter Berger, Doris Marko
Anti-oxidant, -inflammatory, and -carcinogenic activities of bioactive plant constituents, such as anthocyanins, have been widely discussed in literature. However, the potential interaction of anthocyanin-rich extracts with routinely used chemotherapeutics is still not fully elucidated. In the present study, anthocyanin-rich polyphenol extracts of blackberry (BB), bilberry (Bil), black currant (BC), elderberry (EB), and their respective main anthocyanins (cyanidin-3- O -glucoside, delphinidin-3- O -glucoside, cyanidin-3- O -rutinoside, and cyanidin-3- O -sambubioside) were investigated concerning their cytotoxic and DNA-damaging properties in murine CT26 cells either alone or in combination with the chemotherapeutic agent SN-38...
November 21, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Weronika Skowrońska, Sebastian Granica, Jakub P Piwowarski, Lejsa Jakupović, Marijana Zovko Končić, Agnieszka Bazylko
ETHNOPHARMACOLOGICAL RELEVANCE: Sambucus nigra L. (Viburnaceae), commonly known as black elderberry, is a native species throughout Europe and western Asia. Elderberry leaves have been used in traditional European medicine, mainly externally, to treat skin and mucosal diseases. They are usually used as decoctions for washing hemorrhoids, ulcers, insect bites, wounds, scrapes, and gingivitis. AIM OF THE STUDY: Our work aimed to scientifically verify the traditional use of the plant material in treating wounds and skin inflammations accompanied by its phytochemical characterization...
November 16, 2023: Journal of Ethnopharmacology
Roberto Rodríguez Madrera, Rosa Pando Bedriñana
The objective of this study is the characterization of the phenolic profile and antioxidant activity of elderberries ( Sambucus nigra L.) from a collection of 79 wild specimens in northern Spain to assess variations in the species at the local level and evaluate its interest as a source of biocompounds. Also, a first study was carried out on the microflora present in this fruit, providing information relevant to its commercial exploitation. Moreover, the phenolic composition, antioxidant capacity and microbial composition in overripe fruits were determined, seeking a better use for this currently wasted resource...
November 9, 2023: Antioxidants (Basel, Switzerland)
Turgay Cetinkaya, Fatih Bildik, Filiz Altay, Zafer Ceylan
The electrospun gelatin nanofibers containing black elderberry (BE) extract, Au nanoparticles (AuNPs) and SnO2 were fabricated as intelligent packaging layer for Hake fish (Merluccius merluccius) fillets. Image analysis confirmed the formation of continuous ultrafine fibers. Differences between nanofibers were evaluated in terms of thermal stability, and chemical composition during storage. Fourier transform infrared spectrums indicated strong bonding interactions between gelatin and other compounds. Thermal analysis results showed that the addition of AuNPs contributed to the thermal stabilization of the gelatin chain...
November 2, 2023: Food Chemistry
Amir-Hossein Bayat, Neda Eskandari, Mojtaba Sani, Farid Fotouhi, Zahra Shenasandeh, Sara Saeidikhoo, Razieh Rohani, Mohammadamin Sabbagh Alvani, Mohammadreza Mafi Balani, Mahdi Eskandarian Boroujeni, Mohammad-Amin Abdollahifar, Faezeh Tajari, Abbas Aliaghaei, Meysam Hassani Moghaddam
The present study was designed to evaluate whether elderberry (EB) effectively reduces inflammation and oxidative stress in hippocampal cells to modify seizure damage. Seizure was induced in rats by the injection of pentylenetetrazol (PTZ). In the Seizure + EB group, EB powder was added to the rats' routine diet for eight consecutive weeks. The study included several behavioral tests, immunohistopathology, Voronoi tessellation (to estimate the spatial distribution of cells in the hippocampus), and Sholl analysis...
October 2023: Toxicology Research
Giovanna Sala, Salvatore Pasta, Antonella Maggio, Tommaso La Mantia
Sambucus nigra , the elderberry, has long been used for its medicinal properties in treating numerous diseases. Based on this traditional knowledge, its different pharmacological activities have been the focus of active research. All parts of the tree have long been used in traditional medicine, that is, the bark, the leaves, the flowers and the fruit. This study, carried out in Sicily (Italy), concerns the traditional uses of elder against human diseases. In order to trace the history of man's interaction with elder on the island, multidisciplinary research was carried out, aiming at (1) presenting a comprehensive overview of elderberry's applications and activities and (2) bridging traditional knowledge (uses and beliefs) with modern science, i...
September 30, 2023: Plants (Basel, Switzerland)
Ioana Mariana Haș, Dan-Cristian Vodnar, Alexa Florina Bungau, Alexandra Georgiana Tarce, Delia Mirela Tit, Bernadette-Emőke Teleky
Interest in functional foods is continuously increasing, having the potential to be an ally in reducing cardiometabolic risk factors. This study focuses on developing and evaluating oat- and millet-based snack bars enriched with freeze-dried elderberry powder (FDEBP), aiming to combine great taste with enhanced nutritional value, antioxidant properties, and prebiotic potential. The research encompassed a sensory evaluation, nutritional assessment, and rheological analysis of the snack bars. A hedonic test was conducted to gauge consumer preferences and overall liking, providing insights into taste, texture, and acceptance...
September 23, 2023: Foods (Basel, Switzerland)
Lenka Česlová, Petra Kalendová, Lucie Dubnová, Marek Pernica, Jan Fischer
This work focusses on the analysis of anthocyanins present in wild Czech elderberries, using spectrophotometric methods and liquid chromatography. Spectrophotometric methods were used to determine antioxidant capacity, total phenolic content, and total anthocyanin content. Further, four major elderberry anthocyanins were determined using reversed-phase high-performance liquid chromatography with isocratic elution of 30% aqueous methanol with 5% of formic acid. All optimised methods were applied to the analysis of extracts prepared from frozen and dried elderberry fruit samples, and the results were evaluated using principal component analysis which clearly divided the samples into individual groups according to the sample pretreatment (frozen and dried samples)...
September 19, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jean Michel Maixent, Meriam Belaiba, Olivier Pons, Enora Roulleau, Jalloul Bouajila, Jean-Marc Zeil
Infusions of Camellia sinensis leaves have been known for their health benefits. The Bio Concentrate Assets® (ABC) method is a method of enriching organic infusion leaves (from Camellia sinensis ) with organic dry and concentrated extracts using organic acacia gum, and its application to white tea has provided Qi cha tea® . In the present study, the content of tea polyphenols and caffeine, and the biochemical properties of Qi cha tea® and its botanical constituents (elderberry, tulsi, Echinacea purpurea , orange peel, lemongrass, and acacia gum) were assessed...
September 11, 2023: Plants (Basel, Switzerland)
Naomi May, Julianna Lys de Sousa Alves Neri, Helen Clunas, Jiahua Shi, Ella Parkes, Anjila Dongol, Zhizhen Wang, Carlos Jimenez Naranjo, Yinghua Yu, Xu-Feng Huang, Karen Charlton, Katrina Weston-Green
Oxidative stress is a common characteristic of psychiatric, neurological, and neurodegenerative disorders. Therefore, compounds that are neuroprotective and reduce oxidative stress may be of interest as novel therapeutics. Phenolic, flavonoid and anthocyanin content, ORAC and DPPH free radical scavenging, and Cu2+ and Fe2+ chelating capacities were examined in variations (fresh/capsule) of Queen Garnet plum (QGP, Prunus salicina ), black pepper ( Piper nigrum ) clove ( Syzygium aromaticum ), elderberry ( Sambucus nigra ), lemon balm ( Melissa officinalis ) and sage ( Salvia officinalis ), plus two blends ( Astralagus membranaceus -lemon balm-rich, WC and R8)...
September 8, 2023: Nutrients
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