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Disposition kinetics of ciprofloxacin in lactating goats.
DTW. Deutsche Tierärztliche Wochenschrift 1998 January
The pharmacokinetics of ciprofloxacin following intravenous and intramuscular administrations in lactating goats were investigated. Ciprofloxacin was administered as a single dose of 5 mg kg-1 body weight for both routes and was assayed in biological fluids, (serum, milk and urine) to determine its concentrations, kinetic behaviour, and systemic availability. Following a single i.v. injection, the serum concentration-time curve was best described by a two-compartment open model. The elimination half-life (t0.5 beta) was 2.78 +/- 0.08 hours. The extent of serum protein binding of ciprofloxacin in goats was 14.2 +/- 1.4%. Volume of distribution at steady-state was 2.14 +/- 0.07 L/kg. Total body clearance of ciprofloxacin in goats was 14.7 +/- 0.43 ml/min/kg. Following a single intramuscular administration, ciprofloxacin was rapidly absorbed and the mean peak serum concentration (1.92 +/- 0.05 micrograms ml-1) was achieved 1 hour post administration. The systemic availability of ciprofloxacin after intramuscular administration was 95.9 +/- 6.4%. The drug was detected in therapeutic concentrations for 10 hours in serum and milk and for 24 hours in urine. Following intramuscular injection at 5 mg kg-1 body weight for 5 consecutive days, ciprofloxacin showed a cumulative behaviour in serum, milk and urine of goats.
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