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Risk of connective tissue disease and related disorders among women with breast implants: a nation-wide retrospective cohort study in Sweden

O Nyrén, L Yin, S Josefsson, J K McLaughlin, W J Blot, M Engqvist, L Hakelius, J D Boice, H O Adami
BMJ: British Medical Journal 1998 February 7, 316 (7129): 417-22

OBJECTIVE: To examine the relation between connective tissue disease and related conditions and breast implants.

DESIGN: Retrospective cohort study of all women in the Swedish national inpatient registry who underwent breast augmentation surgery with artificial implants during 1964-93, compared with women who underwent breast reduction surgery during the same period.

SETTING: Sweden.

SUBJECTS: 7442 women with implants for cosmetic reasons or for reconstruction after breast cancer surgery and 3353 women with breast reduction surgery.

MAIN OUTCOME MEASURES: Subsequent hospitalisation for definite connective tissue diseases (rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, dermatomyositis, and Sjögren's syndrome) or related disorders.

RESULTS: 29 women with implants were hospitalised for definite connective tissue disease compared with 25.5 expected based on general population rates (standardised hospitalisation ratio 1.1 (95% confidence interval 0.8 to 1.6)). There were no diagnoses of systemic sclerosis, and no significant excess in risk for polymyalgia rheumatica, fibromyalgia, and several related disorders. Among women who underwent breast reduction surgery, 14 were hospitalised for definite connective tissue disease compared with 10.5 expected (standardised hospitalisation ratio 1.3 (0.7 to 2.2)). Compared with the breast reduction group, women with breast implants showed a slight reduction for all definite connective tissue disease (relative risk 0.8 (95% confidence interval 0.5 to 1.4)).

CONCLUSIONS: This large nationwide cohort study shows no evidence of association between breast implants and connective tissue disease.

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