Immune response to the filaria Litomosoides sigmodontis in susceptible and resistant mice

P Maréchal, L Le Goff, W Hoffman, J Rapp, I P Oswald, C Ombrouck, D W Taylor, O Bain, G Petit
Parasite Immunology 1997, 19 (6): 273-9
Comparisons were made between the immune responses evoked during the course of chronic and patient infections of Litomosoides sigmodontis in susceptible BALB/c mice and non-patent infections in resistant B10.D2 mice. Early antigen specific responses of spleen cells were weak in both mouse strains. However, by day 58 post infection a strong Th2 response, as determined by production of IL-4, IL-5 and IL-10, was observed in BALB/c mice but not in B10.D2 mice. Antibody responses seemed to appear sooner in B10.D2 than in BALB/c mice, and these differentially recognised two antigens of 15 kD and 80 kD.

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