JOURNAL ARTICLE

Inhibition of collagenases from mouse lung carcinoma cells by green tea catechins and black tea theaflavins

M Sazuka, H Imazawa, Y Shoji, T Mita, Y Hara, M Isemura
Bioscience, Biotechnology, and Biochemistry 1997, 61 (9): 1504-6
9339552
Theaflavin and theaflavin digallate, which are components of black tea were examined by in vitro invasion assay with mouse Lewis lung carcinoma LL2-Lu3 cells, which are highly metastatic. The compounds inhibited invasion by the tumor cells. Gelatin zymography showed that the cells secreted matrix metalloproteinases (MMPs), probably including MMP-2 and MMP-9, which may be involved in tumor cell invasion and metastasis. Theaflavin and theaflavin digallate also inhibited MMPs from the culture medium of these tumor cells, as did (-)-epigallocatechin gallate. These results suggest that theaflavin, theaflavin digallate, and (-)-epigallocatechin gallate inhibit tumor cell invasion by inhibiting type IV collagenases of the LL2-Lu3 cells.

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