Cytomegalovirus infections and anti-GM2 antibodies in Guillain-Barré syndrome

B C Jacobs, P A van Doorn, J H Groeneveld, A P Tio-Gillen, F G van der Meché
Journal of Neurology, Neurosurgery, and Psychiatry 1997, 62 (6): 641-3
To investigate whether antecedent cytomegalovirus (CMV) infections in patients with Guillain-Barré syndrome are associated with the presence of specific antiganglioside antibodies, acute phase serum samples from 130 patients with Guillain-Barré syndrome and 200 controls were tested. Anti-GM2 IgM antibodies were found more often in patients with Guillain-Barré syndrome with CMV infection (22%) than in patients without the infection (2%) (P = 0.003). CMV infections may elicit anti-GM2 antibodies in susceptible patients, which may contribute to the pathogenesis of Guillain-Barré syndrome associated with CMV.

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