We have located links that may give you full text access.
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Effects of putative K+ channel blockers on beta-adrenoceptor-mediated vasorelaxation of rat mesenteric artery.
Journal of Cardiovascular Pharmacology 1997 April
The aim of our study was to investigate the contribution of Ca(2+)-activated K+ channels (KCa channels) and ATP-sensitive K+ channels (KATP channels) to the vasodilator responses to beta-adrenoceptor agonists in the rat isolated mesenteric artery. Isoprenaline and fenoterol concentration-dependently relaxed the phenylephrine-precontracted endothelium-intact arterial rings with 50% inhibitory concentration (IC50) of 0.0314 +/- 0.027 microM (n = 20) and 0.40 +/- 0.04 microM (n = 11), respectively. Charybdotoxin (100 nM) displaced the isoprenaline or fenoterol logarithmic concentration-relaxation curve to the right in the absence and presence of endothelium. In contrast, glibenclamide (10 microM) did not affect the effects of isoprenaline and fenoterol, whereas glibenclamide (3 microM) significantly inhibited the cromakalim-induced vasorelaxation. Neither charybdotoxin (100 nM) nor glibenclamide (10 microM) influenced the vasorelaxation induced by forskolin. Ba2+, a nonselective blocker of K+ channels, inhibited the relaxant effects of isoprenaline and forskolin. These results suggest that KCa but not KATP channels contribute to beta-adrenoceptor-mediated vasodilator response in rat mesenteric artery, and cyclic adenosine monophosphate (cAMP) might not be involved in regulation of the activity of KCa channels.
Full text links
Trending Papers
A Personalized Approach to the Management of Congestion in Acute Heart Failure.Heart International 2023
Potential Mechanisms of the Protective Effects of the Cardiometabolic Drugs Type-2 Sodium-Glucose Transporter Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Heart Failure.International Journal of Molecular Sciences 2024 Februrary 21
The Effect of Albumin Administration in Critically Ill Patients: A Retrospective Single-Center Analysis.Critical Care Medicine 2024 Februrary 8
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app