We have located links that may give you full text access.
JOURNAL ARTICLE
REVIEW
The pathogenesis of gastroesophageal reflux disease: the relationship between epithelial defense, dysmotility, and acid exposure.
American Journal of Gastroenterology 1997 April
Gastroesophageal reflux disease (GERD) is a complex, multifactorial disease for which the initiating factors are unknown. Acid in contact with the esophageal epithelium, however, is a central event in the development of the disease--the disease developing when acid overwhelms the intrinsic esophageal epithelial defenses. Acid breakdown of the tissue defenses is what ultimately leads to symptom production, ulceration, and other complications of GERD. Patients with GERD generally, although not always, have more episodes of reflux than healthy subjects; this is due to more frequent transient lower esophageal sphincter relaxations in the disease group. GERD patients may also have some impairment in peristaltic frequency on swallowing and/or weakness in the strength of peristaltic contractility. Contributions from other components of the acid clearance and tissue-defensive mechanisms are possible but remain to be adequately established as contributing to GERD. It is likely that one reason for the wide clinical spectrum observed with GERD results from differences in types and degrees of defects within the tripartite esophageal defensive system against damage from the phenomenon of gastroesophageal reflux.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app