JOURNAL ARTICLE

Onchocerciasis: clinical presentation and host parasite interactions in patients of southern Sudan

P Stingl
International Journal of Dermatology 1997, 36 (1): 23-8
9071610

BACKGROUND: Onchocerciasis, an infection by the filarial nematode Onchoverca volvulus, is widely distributed in tropical Africa and of great dermatologic interest. This study analyses the dermatologic presentation and tries to determine the correlations between clinical disease and host parasite interactions in onchocerciasis patients of the Southern Sudan.

METHODS: We performed clinical and histopathologic investigations in patients with onchocerciasis in the Wau District, Bahr el Ghazal Province, Southern Sudan. As well as a detailed clinical skin examination, skin biopsies were taken, processed, and investigated for type and degree of host tissue response. Parasitologic, clinical, and histopathologic findings were evaluated.

RESULTS: Onchocerciasis appears with a variety of severe skin lesions. Central is a pruritic rash. Long-standing cases develop extensive pigmentary changes and impressive signs of skin tissue exhaustion. Cellular host tissue responses to degenerating skin microfilariae seem to play a key role in the development of skin pathology. The degree of host response appears to be inversely proportional to the host's microfilarial load.

CONCLUSIONS: Onchocerciasis represents a health problem of great dermatologic importance in Southern Sudan. The study results demonstrate clinical variations in onchocerciasis and provide support for the existence of a disease spectrum.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Trending Papers

Remove bar
Read by QxMD icon Read
9071610
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.