We have located links that may give you full text access.
Combinations of IgE values and lymphocyte proliferative responses for consideration of the clinical course of infantile hen's-egg-sensitive atopic dermatitis.
International Archives of Allergy and Immunology 1997 Februrary
We have attempted a new approach, using peripheral blood mononuclear cells (PBMCs), to predict the clinical course of infantile food-sensitive atopic dermatitis (AD). In this study, we investigated the relationships between the clinical course of infantile hen's-egg-sensitive AD and laboratory data obtained at the early stage of AD, particularly on combinations of specific IgE antibodies to hen's egg and proliferative responses of PBMCs to ovalbumin (OA). Total IgE concentrations, specific IgE antibodies to hen's egg and proliferative responses of PBMCs to OA were measured in 31 hen's-egg-sensitive AD patients within 6 months after development of AD symptoms. After the acquisition of laboratory data, the clinical courses of all patients were followed up for 1 year. The stimulation index of proliferative responses of PBMCs to OA in hen's-egg-sensitive AD patients whose symptoms did not improve was significantly (p < 0.05) higher than that in hen's-egg-sensitive AD patients whose symptoms improved. On the other hand, the radioallergosorbent test (RAST) scores for hen's egg were not statistically different between the two groups. The degree of refractoriness of AD symptoms tended to be higher in the patients who showed a higher total IgE concentration at the beginning of the clinical course than in those who showed a lower one. These results might be attributed to the underlying cause of AD, i.e., a cell-mediated and an IgE-mediated allergy. We concluded that, in addition to total IgE concentrations, combinations of RAST values and lymphocyte proliferative responses to OA are important to predict the clinical course of infantile hen's-egg-sensitive AD.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app