We have located links that may give you full text access.
Potential enhancement of endometrial receptivity in cycles using controlled ovarian hyperstimulation with antiprogestins: a hypothesis.
Fertility and Sterility 1997 Februrary
OBJECTIVE: To manipulate the luteal endometrial progression by the use of antiprogestins.
DESIGN: Prospective controlled clinical trial.
SETTING: The IVF program of the University of Southern California School of Medicine, Los Angeles, California.
PATIENT(S): Thirteen oocyte donors and 20 oocyte recipients.
INTERVENTION(S): Controlled ovarian hyperstimulation of oocyte donors, administration of two doses of 2.5 mg of RU486 to the study group, and endometrial biopsies.
MAIN OUTCOME MEASURE(S): Serum E2 and P levels, histologic dating of the endometrium, endometrial ultrastructure by scanning electron microscopy.
RESULT(S): No difference in serum E2 or P levels was noted after RU486 administration. The histologic dating was advanced in oocyte donors as compared with recipients undergoing artificial cycles but returned to normal (in phase) after RU486. Pinopods were noted in all recipient biopsies and in donors treated with RU486 but in only one of four biopsies in donor controls.
CONCLUSION(S): Cycles with controlled ovarian hyperstimulation are associated with high early luteal P levels and advanced endometrial histology. Low doses of RU486 may correct the precocious luteinization and restore endometrial receptivity.
DESIGN: Prospective controlled clinical trial.
SETTING: The IVF program of the University of Southern California School of Medicine, Los Angeles, California.
PATIENT(S): Thirteen oocyte donors and 20 oocyte recipients.
INTERVENTION(S): Controlled ovarian hyperstimulation of oocyte donors, administration of two doses of 2.5 mg of RU486 to the study group, and endometrial biopsies.
MAIN OUTCOME MEASURE(S): Serum E2 and P levels, histologic dating of the endometrium, endometrial ultrastructure by scanning electron microscopy.
RESULT(S): No difference in serum E2 or P levels was noted after RU486 administration. The histologic dating was advanced in oocyte donors as compared with recipients undergoing artificial cycles but returned to normal (in phase) after RU486. Pinopods were noted in all recipient biopsies and in donors treated with RU486 but in only one of four biopsies in donor controls.
CONCLUSION(S): Cycles with controlled ovarian hyperstimulation are associated with high early luteal P levels and advanced endometrial histology. Low doses of RU486 may correct the precocious luteinization and restore endometrial receptivity.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app