JOURNAL ARTICLE
REVIEW

Functional diversity of helper T lymphocytes

A K Abbas, K M Murphy, A Sher
Nature 1996 October 31, 383 (6603): 787-93
8893001
The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. Defining the cellular and molecular mechanisms of helper-T-cell differentiation should lead to rational strategies for manipulating immune responses for prophylaxis and therapy.

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