Sjögren's syndrome presenting as hypokalemic paralysis due to distal renal tubular acidosis

O Zimhony, Z Sthoeger, D Ben David, Y Bar Khayim, D Geltner
Journal of Rheumatology 1995, 22 (12): 2366-8
A 57-year-old woman presented with a flaccid paralysis, muscle tenderness, and respiratory depression. Laboratory results demonstrated severe hypokalemia with hyperchloremic metabolic acidosis and abnormally acidified urine. The urinary anion gap was positive in the presence of acidemia, thus establishing the diagnosis of distal renal tubular acidosis (DRTA). The patient fully recovered after potassium and alkali replacement. Further investigation revealed Sjögren's syndrome as the underlying cause of DRTA.

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