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Hydroxychloroquine and lupus pregnancy: review of a series of 36 cases.
Annals of the Rheumatic Diseases 1996 July
OBJECTIVE: To study maternal and fetal outcome of pregnancy in patients with lupus who were exposed to hydroxychloroquine (HCQ).
METHODS: The case records of women (n = 33) exposed to HCQ during their pregnancies (n = 36) and of 53 control patients from a single lupus pregnancy centre were reviewed to determine lupus activity, obstetric experience, and infant outcome.
RESULTS: HCQ was not apparently teratogenic. Lupus activity and obstetric outcome in the two groups were similar.
CONCLUSION: HCQ continuation is probably safe during pregnancy in patients with lupus, but there is no obvious advantage in commencing treatment.
METHODS: The case records of women (n = 33) exposed to HCQ during their pregnancies (n = 36) and of 53 control patients from a single lupus pregnancy centre were reviewed to determine lupus activity, obstetric experience, and infant outcome.
RESULTS: HCQ was not apparently teratogenic. Lupus activity and obstetric outcome in the two groups were similar.
CONCLUSION: HCQ continuation is probably safe during pregnancy in patients with lupus, but there is no obvious advantage in commencing treatment.
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