Effects of caffeine and tryptophan on rectal temperature, metabolism, total exercise time, rate of perceived exertion and heart rate

M N Alves, W M Ferrari-Auarek, K M Pinto, K R Sá, J P Viveiros, H A Pereira, A M Ribeiro, L O Rodrigues
Brazilian Journal of Medical and Biological Research 1995, 28 (6): 705-9
Stimulant properties during exercise have been attributed to caffeine (CAF) and tryptophan (Trp). The purpose of the present study was to investigate the effects of CAF and Trp ingestion on rectal temperature (Tre), total exercise time (TET), oxygen consumption (VO2), carbon dioxide production (VCO2), pulmonary ventilation (VE), heart rate (HR) and rate of perceived exertion (RPE) during exercise on a cycle ergometer at 80% of maximal work load, in eight healthy male volunteers. Each subject abstained from caffeine for 48 h and from animal-derived foods for 36 h before each experiment. Aerobic capacity was determined on the first day. In consecutive trials, conducted in a double-blind, randomized, crossed-over manner, each subject received capsules containing CAF (10 mg/kg), Trp (1.2 g), a combination of the two (CAF+Trp), and lactose (PLA), 1 h before exercise. Plasma CAF concentration (PC) was measured by high performance liquid chromatography (HPLC), before (basal concentration) and 1 and 2 h after ingestion of the capsules. At both times after CAF or CAF+Trp ingestion, the PC was elevated compared with the basal concentration (P < 0.05). During exercise, significant increases occurred with time in Tre, TET, VO2, VCO2, VE, HR and RPE (P < 0.01) while no significant difference was observed when CAF or CAF+Trp were compared with control values. Under the conditions of this study, CAF and/or Trp did not affect the physiological parameters measured before, during or after exercise at 80% of maximal work load.

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