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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
31P-nuclear magnetic resonance spectroscopy study of the time course of energy metabolism during exercise and recovery.
This study evaluated the time courses of intracellular pH and the metabolism of phosphocreatine (PCr) and inorganic phosphate (Pi) at the onset of four exercise intensities and recoveries. Non-invasive evaluation of continuous changes in phosphorus metabolites has become possible using 31P-nuclear magnetic resonance spectroscopy (31P-MRS). After measurements at rest, six healthy male subjects performed 4 min of femoral flexion exercise at intensities of 0 ("loadless"), 10, 20 and 30 kg.m.min-1 in a 2.1 T superconducting magnet with a 67-cm bore. Measurements were continuously made during 5 min of recovery. During a series of rest-exercise-recovery procedures, 31P-MRS were accumulated using 32 scans-spectrum-1 requiring 12.8 s each. At the onset of exercise, PCr decreased exponentially with a time constant of 27-32 s regardless of the exercise intensity. The time constant PCr resynthesis during recovery was about 27-40 s. The PCr kinetics were independent of exercise intensity. There were similar Pi kinetics at the onset of all types of exercise, while those of Pi recovery became significantly longer at the higher exercise intensities (P < 0.05). Furthermore, the intracellular pH indicated temporary alkalosis just at the onset of exercise, probably due to absorption of hydrogen ions by PCr hydrolysis, and then decrease at a point about 40%-50% of the pre-exercise PCr. The pH recovery time was longer than that for the Pi or PCr kinetics. By using a more efficient resolution system it was possible to obtain the phosphorus kinetics during exercise and to follow PCr resynthesis within the first few minutes of recovery.(ABSTRACT TRUNCATED AT 250 WORDS)
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