Cold agglutinin disease following allogeneic bone marrow transplantation

T Tamura, H Kanamori, E Yamazaki, M Ohtsuka, K Hataoka, K Maeda, R Okamoto, J Tanabe, H Fujita, Y Hashimoto
Bone Marrow Transplantation 1994, 13 (3): 321-3
We describe a case of cold agglutinin disease (CAD) following allogeneic bone marrow transplantation. This 36-year-old male developed CAD 3 weeks after allogeneic bone marrow transplantation for chronic myelogenous leukemia. Cyclosporin A and methotrexate had been administered to prevent graft-versus-host disease. Other agents administered included cytomegalovirus hyperimmune globulin and recombinant human G-CSF. Pericarditis preceded the development of CAD. The characterization of cold agglutinin (CA) was monoclonal IgM-kappa with anti-Pr antigen specificity, probably derived from the engrafted donor lymphocytes. The administration of prednisolone led to transient improvement. The CA titer decreased without further treatment 12 weeks after transplant.

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