JOURNAL ARTICLE

[A case of oligomeganephronia—quantitative measurement of the glomerular surface area and the number of glomeruli with a color image analyzer]

T Ohshima, S Inaba, M Arai, Y Sakai, K Kurose, S Ishihara, T Takahashi, R Takai, H Matukura, R Yoshida
Nihon Jinzo Gakkai Shi 1994, 36 (3): 271-6
8196224
We report here a nine-year-old boy with oligomeganephronia. The patient had proteinuria and morphometric analysis of the renal biopsy specimen confirmed the diagnosis of oligomeganephronia. We employed a color image analyzer (OLYMPUS Corp.) to determine the glomerular surface area and the number of glomeruli per mm2 of the renal cortex of the patient. All the scanned glomeruli showed marked hypertrophy; the mean maximal surface area for the 5 glomeruli was 46 x 10(3) microns 2, which is approximately 4 times larger than that of normal children of the same age. The number of glomeruli per mm2 of the renal cortex of the patient had decreased to 1. 11 per mm2, which is approximately one fourth that of normal controls with IgA glomerulonephritis. The color image analyzer proved to be useful for the diagnosis of oligomeganephronia enabling the quantitative measurement of the glomerular surface area and the number of glomeruli per mm2 of the renal cortex.

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