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CASE REPORTS
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
Development of neurologic symptoms in a patient with asymptomatic Wilson's disease treated with penicillamine.
Archives of Neurology 1994 March
OBJECTIVE: To report a case of presymptomatic Wilson's disease in a patient who became severely neurologically disabled after treatment with penicillamine and to discuss alternative initial therapy for such patients.
DESIGN: Case report. The patient described is briefly compared with a previously studied group of 13 similar presymptomatic patients who received zinc therapy without any clinical worsening and who have had 3 to 9 years of follow-up.
SETTING: Referral hospital.
PATIENTS: The patient was referred to us.
INTERVENTION: The patient had initially been treated with penicillamine.
MAIN OUTCOME MEASURE: The main outcome of interest is permanent neurologic disability, depending on type of initial treatment.
RESULTS: The result of initial penicillamine therapy in the patient described is permanent neurologic disability. This is believed to be due to mobilization and redistribution of hepatic copper causing higher levels of copper in key areas of the brain.
CONCLUSION: We conclude that penicillamine used as initial therapy, even in patients with neurologically asymptomatic Wilson's disease, increases the risk of inducing permanent neurologic damage.
DESIGN: Case report. The patient described is briefly compared with a previously studied group of 13 similar presymptomatic patients who received zinc therapy without any clinical worsening and who have had 3 to 9 years of follow-up.
SETTING: Referral hospital.
PATIENTS: The patient was referred to us.
INTERVENTION: The patient had initially been treated with penicillamine.
MAIN OUTCOME MEASURE: The main outcome of interest is permanent neurologic disability, depending on type of initial treatment.
RESULTS: The result of initial penicillamine therapy in the patient described is permanent neurologic disability. This is believed to be due to mobilization and redistribution of hepatic copper causing higher levels of copper in key areas of the brain.
CONCLUSION: We conclude that penicillamine used as initial therapy, even in patients with neurologically asymptomatic Wilson's disease, increases the risk of inducing permanent neurologic damage.
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