Pharmacological effects of ibudilast on cerebral circulation: a PET study

H Fukuyama, J Kimura, S Yamaguchi, H Yamauchi, M Ogawa, T Doi, Y Yonekura, J Konishi
Neurological Research 1993, 15 (3): 169-73
To evaluate the pharmacological effects of ibudilast on cerebral circulation, we examined 5 ischaemic stroke patients, using positron emission tomography, and we measured cerebral blood flow (CBF). Ibudilast loading per os led to a remarkable increase in CBF after 30 min. This CBF elevation was observed in the lesion side as well as in the nonlesion hemisphere. Therefore, we can confirm that ibudilast ameliorates the chronic low perfusion state of CBF in the ischaemic stroke patient.

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