Read by QxMD icon Read

An explanation of the asthma paradox

C P Page
American Review of Respiratory Disease 1993, 147 (6): S29-32
The morbidity and mortality associated with asthma are rising, despite increased usage of anti-asthma medications. This report attempts to provide a plausible hypothesis for the "asthma paradox." The hypothesis involves the role of mast cell degranulation as an endogenous anti-inflammatory mechanism to prevent antigens from entering the lower airways and to limit the extent of the subsequent repair process. By treating symptoms of asthma with drugs such as beta 2 agonists that inhibit mast cell degranulation, increased inflammation is allowed to occur, which may lead to the chronic appearance of excess repair tissue and the acceleration of the disease process.


You need to log in or sign up for an account to be able to comment.

No comments yet, be the first to post one!

Trending on Read

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"