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English Abstract
Journal Article
Review
[Action mechanisms of intravenous anesthetics].
Tidsskrift for Den Norske Lægeforening : Tidsskrift for Praktisk Medicin, Ny Række 1993 Februrary 21
Intravenous anaesthetic agents depress the activity of the brain by acting on receptor-operated ion channels. Barbiturates enhance gamma-aminobutyric acid (GABA)-mediated inhibition, depress glutamate-mediated excitation, and hyperpolarize the membrane by increased potassium conductance. Benzodiazepines facilitate GABA-mediated inhibition by binding to a benzodiazepine recognition site on the GABA receptor complex, and affect potassium channels. Opioids bind to opioid receptors and hyperpolarize the membrane by enhanced potassium and calcium conductances. Ketamine depresses excitatory synaptic transmission by acting on glutamate receptors of the N-methyl-D-aspartate (NMDA) subtype. Propofol acts at a recognition site on the GABA receptor, which differs from the binding sites of both barbiturates and benzodiazepines.
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