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Sucralfate suspension as a treatment of recurrent aphthous stomatitis.

DESIGN: A prospective randomized, double-blind, placebo-controlled, cross-over clinical trial.

SETTING: A university hospital.

SUBJECTS: Twenty-one patients with symptomatic recurrent aphthous stomatitis (RAS), unresponsive to conventional treatment were enrolled. They were divided into three groups.

INTERVENTION: In a cross-over trial, the patients received an oral suspension of sucralfate, an antacid solution or a placebo for 2 years.

RESULTS: After 2 years of follow-up, sucralfate was found to be superior to both placebo and antacid (P < 0.001) with regard to duration of pain, reduction of the healing period, response time to first treatment and duration of remission.

CONCLUSION: Sucralfate suspension should be added to the armament of treatment modalities of RAS.

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