We report a case of bullous systemic lupus erythematosus (SLE). The patient suddenly presented with a widespread blistering eruption on the trunk and neck during the course of treatment of SLE. A skin biopsy specimen showed subepidermal blisters, and direct immunofluorescence (IF) revealed deposition of IgA, IgG and IgM at the dermoepidermal junction. Indirect IF showed linear IgG deposition along the base of 1 M NaCl-split skin. Rapid resolution of the blisters occurred following treatment with dapsone 50 mg daily.