Two different isoforms of desmocollin are recognized by autoantibodies in various types of pemphigus

T Hashimoto, T Ebihara, T Nishikawa
Dermatology: International Journal for Clinical and Investigative Dermatology 1994, 189 Suppl 1: 124-5
We have previously reported that, in addition to well-known pemphigus antigens (desmoglein and pemphigus vulgaris antigen), desmocollin (Dsc), another desmosomal cadherin, is recognized by certain pemphigus sera. Furthermore, we noticed that two Dsc species with a slightly different relative molecular weight were recognized by various pemphigus sera. This difference may contribute to the different clinicopathological features between the subcorneal pustular dermatosis type and the intraepidermal neutrophilic IgA dermatosis type of intercellular IgA vesiculopustular dermatosis.

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