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Myelodysplasia following paroxysmal nocturnal haemoglobinuria: evidence for the emergence of a separate clone.

H van Kamp, J W Smit, E van den Berg, M Ruud Halie, E Vellenga
British Journal of Haematology 1994 June
A patient with paroxysmal nocturnal haemoglobinuria (PNH) who developed a myelodysplastic syndrome (MDS) is described. After the onset of myelodysplasia the neutrophils of the patient fully expressed GPI-linked proteins. It is concluded that the myelodysplasia does not originate from transformed PNH stem cells, but represents the emergence of a separate clone arising from an injured marrow.

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