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Depot antipsychotics in the prophylaxis of bipolar affective disorder.
British Journal of Psychiatry 1994 December
BACKGROUND: The efficacy of depot antipsychotic drugs in the prophylaxis of bipolar affective disorder was investigated.
METHOD: Life charts were constructed for 18 outpatients with bipolar disorder receiving prophylactic treatment with depot medication. The durations of affective episodes were compared during periods on or off medication.
RESULTS: The subjects suffered fewer relapses and spent significantly less time in hospital (P = 0.001) for treatment of manic, depressive and mixed affective illness during treatment with depot antipsychotics.
CONCLUSIONS: Depot antipsychotic medication may be a useful prophylactic treatment for certain patients with bipolar affective disorder.
METHOD: Life charts were constructed for 18 outpatients with bipolar disorder receiving prophylactic treatment with depot medication. The durations of affective episodes were compared during periods on or off medication.
RESULTS: The subjects suffered fewer relapses and spent significantly less time in hospital (P = 0.001) for treatment of manic, depressive and mixed affective illness during treatment with depot antipsychotics.
CONCLUSIONS: Depot antipsychotic medication may be a useful prophylactic treatment for certain patients with bipolar affective disorder.
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